Home Cart 0 Sign in  
X

[ CAS No. 215437-47-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 215437-47-1
Chemical Structure| 215437-47-1
Chemical Structure| 215437-47-1
Structure of 215437-47-1 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 215437-47-1 ]

Related Doc. of [ 215437-47-1 ]

Alternatived Products of [ 215437-47-1 ]

Product Details of [ 215437-47-1 ]

CAS No. :215437-47-1 MDL No. :MFCD11976459
Formula : C12H10ClNO Boiling Point : -
Linear Structure Formula :- InChI Key :SXOVMWQGOMWDHU-UHFFFAOYSA-N
M.W :219.67 Pubchem ID :10932953
Synonyms :

Safety of [ 215437-47-1 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H312-H315-H319-H332-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 215437-47-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 215437-47-1 ]

[ 215437-47-1 ] Synthesis Path-Downstream   1~25

  • 1
  • [ 4214-79-3 ]
  • [ 100-44-7 ]
  • [ 215437-47-1 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N-methyl-acetamide; nitrogen; ethyl acetate; toluene; 2 Synthesis of 2-Benzyloxy-5-chloropyridine: In a reaction flask were charged 10 g of <strong>[4214-79-3]5-chloro-2-hydroxypyridine</strong>, 11.73 g of benzyl chloride, 16 g of potassium carbonate, and 250 ml of dimethylformamide in a nitrogen stream, and the mixture was reacted at 80° C. for 2 hours. After cooling, the organic layer was filtered, and the salt was washed with ethyl acetate and filtered. The solvent was evaporated, and the residue was purified by column chromatography using 150 g of silica gel and a 5:1 (by volume) mixture of toluene and ethyl acetate as a developing solvent to give 14.5 g of the title compound.
  • 2
  • Ni(Ph2 P(CH2)3 PPh2)Cl2 [ No CAS ]
  • [ 106418-67-1 ]
  • [ 215437-47-1 ]
  • 2-Benzyloxy-5-(4-decylphenyl)-pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With iodine; magnesium; In tetrahydrofuran; nitrogen; ethyl acetate; toluene; 3 Synthesis of 2-Benzyloxy-5-(4-decylphenyl)-pyridine: In a reaction flask were charged 2.17 g of magnesium, 50 ml of THF, and a small amount of iodine in a nitrogen stream. A part of a solution of 26.8 g of 4-decylbromobenzene in 134 ml of THF was added thereto dropwise to initiate reaction. The rest of the solution was added thereto dropwise at 35 to 40 C. over 1 hour, and the mixture was allowed to react at that temperature for 2 hours, followed by cooling to prepare a Grignard reagent. In a reaction flask previously purged with nitrogen were charged 15.2 g of 2-benzyloxy-5-chloropyridine, 150 ml of THF, and 2.68 g of Ni(Ph2 P(CH2)3 PPh2)Cl2, and the above prepared Grignard reagent was added thereto dropwise over a 20-minute period. After the addition, the reaction was further continued at the same temperature for 1 hour. The reaction mixture was poured into ice-water and extracted with toluene. The organic layer was separated by filtration, and the solvent was removed therefrom by evaporation to give 37.18 g of a crude product. Purification by column chromatography using 450 g of silica gel and a 5:1 (by volume) mixture of toluene and ethyl acetate gave 19.9 g of the title compound.
  • 3
  • Ni(Ph2 P(CH2)2 PPh2)Cl2 [ No CAS ]
  • [ 119828-40-9 ]
  • [ 215437-47-1 ]
  • 5-(4-Decyloxy-3-fluorophenyl)-2-benzyloxypyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
49% With ammonium chloride; iodine; magnesium In tetrahydrofuran; nitrogen; ethyl acetate; toluene 25.4 4 4 Synthesis of 5-(4-Decyloxy-3-fluorophenyl)-2-benzyloxypyridine: 3.08 g (127 mmol) of magnesium, 60 ml of THF and a small amount of iodine were charged into a reaction flask in a stream of nitrogen. Subsequently, a solution of 40 g of 3-fluoro-4-decyloxybromobenzene in 60 ml of THF was partly added dropwise to the reaction solution to initiate reaction. The remainder of the solution was then added dropwise to the reaction mixture at a temperature of from 35° C. to 40° C. After the completion of the dropwise addition, the reaction mixture was allowed to undergo reaction at the same temperature for 2 hours, and then cooled to obtain a Grignard reagent. Subsequently, 25.2 g (115 mmol) of 2-benzyloxy-5-chloropyridine, 100 ml of THF and 0.5 g of Ni(Ph2 P(CH2)2 PPh2)Cl2 were charged into a reaction flask the air in which had been replaced by nitrogen. The foregoing Grignard reagent was then added dropwise to the reaction mixture at the same temperature in 20 minutes. After the completion of the dropwise addition, the reaction mixture was allowed to undergo reaction at a temperature of 60° C. for 3 hours. The reaction product was then put into an aqueous solution of ammonium chloride. The reaction product was extracted with a 1:1 (by volume) mixture of toluene and ethyl acetate, and then dried. The reaction product was then purified by silica gel column chromatography to obtain 24.5 g of the title compound (yield: 49%).
  • 4
  • [ 16110-09-1 ]
  • [ 100-51-6 ]
  • [ 215437-47-1 ]
YieldReaction ConditionsOperation in experiment
91% Stage #1: 2,5 dichloropyridine In N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere; Stage #2: benzyl alcohol In N,N-dimethyl-formamide at 5℃; Inert atmosphere; 129.1 Step 1 : To a solution of 2,5-dichloropyridine (2 g, 13.51 mmol, 1.0 eq) in DMF (30 mL) under nitrogen atmosphere at 0 °C was added sodium hydride (0.65 g, 16.21 mmol, 1.2 eq) in portions. The mixture was stirred for 0.5 h and followed by addition of a solution of BnOH (1.75 g, 16.21 mmol, 1.2 eq) in DMF (2 mL). Then the resulting mixture was stirred at 5 °C overnight before it was diluted with water (90 mL) and extracted with EtOAc (3 x 90 mL). The combined organic layer was washed with brine, dried over NaiSCL, and concentrated. The crude residue was purified by flash column chromatography on silica gel (petroleum ether:EtOAc=100: l) to give 2-(benzyloxy)-5-chloropyridine (2.7 g, 91% yield).
With potassium <i>tert</i>-butylate In N,N-dimethyl-formamide at 0 - 20℃; for 2.5h; Cooling with ice-water; 14.A SYNTHESIS EXAMPLE 14; Preparation of 5-chloro-4-[[(4,5-dihydro-5,5-dimethyl-3-isoxazolyl)sulfonyl]methyl]-l- methyl-3-(trifluoromethyl)-2(lH)-pyridinone (Compound 241); Step A: Preparation of 5-chloro-2-(phenylmethoxy)pyridine; To a solution of 2,5-dichloropyridine (14.8 g, 0.1 mol) and benzyl alcohol (11.4 rnL, 0.11 mol) in N,Λ/-dimethylformamide (100 mL) cooled using an external ice-water bath was added potassium t-butoxide (12.3 g, 0.11 mol) in portions. The mixture was stirred at 0 0C for 1 h and then at ambient temperature for 1.5 h before being diluted with hexanes and washed with water (2x). The organic phase was concentrated, and the residue was purified by filtration through a pad of silica gel using 10% 1-chlorobutane in hexanes as eluant. Concentration of the eluant afforded the title product as white crystals (16 g). 1H NMR (CDCl3) δ 8.11 (d, IH), 7.53 (dd, IH), 7.44 (d, 2H), 7.37 (t, 2H), 7.33 (m, IH), 6.76 (d, IH), 5.34 (s, 2H).
  • 5
  • [ 124-38-9 ]
  • [ 215437-47-1 ]
  • [ 74-88-4 ]
  • [ 1202474-04-1 ]
YieldReaction ConditionsOperation in experiment
Stage #1: 5-chloro-2-(phenylmethoxy)pyridine With n-butyllithium; diisopropylamine In tetrahydrofuran; hexanes at -70 - -65℃; Stage #2: carbon dioxide In tetrahydrofuran; hexanes for 0.416667h; Stage #3: methyl iodide In tetrahydrofuran; hexanes at 20℃; 14.B Step B: Preparation of methyl 5-chloro-2-(phenylmethoxy)-4-pyridinecarboxylate; n-Butyllithium (2.5 M in hexanes, 9.7 mL, 24 mmol) was added to a solution of diisopropylamine (3.7 mL, 26 mmol) in tetrahydrofuran (80 mL) at -15 0C causing the temperature to rise to -5 0C. After 5 min, the solution was cooled to -70 0C, and a solution of 5-chloro-2-(phenylmethoxy)pyridine (i.e. the product of Step A) (4.82 g, 21.9 mmol) in tetrahydrofuran (20 mL) was added dropwise, at a rate such that the temperature remained below -65 0C. The reaction mixture was stirred for 1.5 h at this temperature and then carbon dioxide gas was introduced into the solution through a Drierite-filled tube for 5 min. After 20 min, iodomethane (5 mL) was added, and the mixture was allowed to warm to ambient temperature and stir overnight. The mixture was diluted with water and washed with ethyl ether. The aqueous phase was acidified with concentrated hydrochloric acid and extracted with dichloromethane (2x). The dichloromethane extracts were dried (MgSOz^), filtered and concentrated to give a yellow solid (3.95 g) which was used without further purification. The solid was dissolved in Λ/,Λ/-dimethylformamide (30 mL) and treated with potassium carbonate (3.10 g, 22.5 mmol) and dimethyl sulfate (1.71 mL, 18 mmol). The mixture was stirred at ambient temperature overnight before being diluted with ethyl ether, washed with water (3x), dried (MgSOz^), filtered and concentrated. The residue was purified by column chromatography using a gradient of hexanes to 10% ethyl acetate in hexanes as eluant to give the title product as a white solid (2.58 g). 1H NMR (CDCl3) δ 8.23 (s, IH), 7.43 (d, 2H), 7.37 (t, 2H), 7.34 (m, IH), 7.17 (s, IH), 5.37 (s, 2H), 3.94 (s, 3H).
  • 6
  • [ 1204483-45-3 ]
  • [ 215437-47-1 ]
  • [ 1204483-21-5 ]
YieldReaction ConditionsOperation in experiment
With sodium hydride In 1-methyl-pyrrolidin-2-one; mineral oil at 220℃; for 1.5h; Microwave irradiation;
  • 7
  • [ 215437-47-1 ]
  • 2-benzyloxy-5-deuteriopyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
97% With bis(η3-allyl-μ-chloropalladium(II)); 1-deuteriodiphenylmethanol; 3-(2,6-dibenzhydryl-4-methylphenyl)-4,5-dimethyl-1-(2,4,6-trimethylbenzyl)imidazolium chloride; caesium carbonate In toluene at 90℃; for 16h; Inert atmosphere;
  • 8
  • [ 215437-47-1 ]
  • [ 108612-54-0 ]
  • 1-[3'-(6''-benzyloxyl)pyridyl]-4-(N-Boc-N-methyl)aminopiperidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With potassium tert-butylate; palladium diacetate; DavePhos; In toluene; at 120℃; for 12h;Inert atmosphere; General procedure: An oven-dried reaction flask, equipped with a reflux condenser was charged with heteroaryl chloride (1.0 mmol), 4-(N-Boc-N-methyl)aminopiperidine (1.3 equiv.), Pd(OAc)2 (3 mol%), DavePhos (3 mol%), t-BuONa (1.2 equiv.). The flask was sealed, and was evacuated and backfilled with argon for three times. Then 3 mL toluene was added to the system with a syringe. The reaction mixture was stirred at 120 C for 12 h. After cooling to the room temperature, the resulting residue was filtered through a plug of silica gel and washed with ethyl acetate. The mixture was then poured into water and extracted. The combined organic layers were washed with brine, dried over MgSO4, and filtered. The solvent was removed under vacuum. The residue was purified by flash column chromatography to afford the desired product.
  • 9
  • [ 215437-47-1 ]
  • [ 1202474-11-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -70 - -65 °C 1.2: 0.42 h 1.3: 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C 2.2: 1 h 3.1: triethylamine / dichloromethane / 16 h / 20 °C 4.1: trifluoroacetic acid / 48 h / 20 °C 5.1: N-iodo-succinimide / N,N-dimethyl-formamide / 3 h / 65 °C 6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C 7.1: water; sodium hydroxide / ethanol / 1 h / 20 °C
  • 10
  • [ 215437-47-1 ]
  • C7H6BrClINO [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -70 - -65 °C 1.2: 0.42 h 1.3: 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C 2.2: 1 h 3.1: triethylamine / dichloromethane / 16 h / 20 °C 4.1: trifluoroacetic acid / 48 h / 20 °C 5.1: N-iodo-succinimide / N,N-dimethyl-formamide / 3 h / 65 °C 6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C 7.1: water; sodium hydroxide / ethanol / 1 h / 20 °C 8.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C
  • 11
  • [ 215437-47-1 ]
  • [ 1202474-06-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -70 - -65 °C 1.2: 0.42 h 1.3: 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C 2.2: 1 h
  • 12
  • [ 215437-47-1 ]
  • [ 1202474-08-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -70 - -65 °C 1.2: 0.42 h 1.3: 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C 2.2: 1 h 3.1: triethylamine / dichloromethane / 16 h / 20 °C 4.1: trifluoroacetic acid / 48 h / 20 °C
  • 13
  • [ 215437-47-1 ]
  • [ 1202474-12-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -70 - -65 °C 1.2: 0.42 h 1.3: 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C 2.2: 1 h 3.1: triethylamine / dichloromethane / 16 h / 20 °C 4.1: trifluoroacetic acid / 48 h / 20 °C 5.1: N-iodo-succinimide / N,N-dimethyl-formamide / 3 h / 65 °C 6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C 7.1: water; sodium hydroxide / ethanol / 1 h / 20 °C 8.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C 9.1: potassium carbonate / acetonitrile / 2 h / 20 °C
  • 14
  • [ 215437-47-1 ]
  • [ 1202474-09-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -70 - -65 °C 1.2: 0.42 h 1.3: 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C 2.2: 1 h 3.1: triethylamine / dichloromethane / 16 h / 20 °C 4.1: trifluoroacetic acid / 48 h / 20 °C 5.1: N-iodo-succinimide / N,N-dimethyl-formamide / 3 h / 65 °C
  • 15
  • [ 215437-47-1 ]
  • [ 1202474-10-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -70 - -65 °C 1.2: 0.42 h 1.3: 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C 2.2: 1 h 3.1: triethylamine / dichloromethane / 16 h / 20 °C 4.1: trifluoroacetic acid / 48 h / 20 °C 5.1: N-iodo-succinimide / N,N-dimethyl-formamide / 3 h / 65 °C 6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C
  • 16
  • [ 215437-47-1 ]
  • [ 1202474-07-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -70 - -65 °C 1.2: 0.42 h 1.3: 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C 2.2: 1 h 3.1: triethylamine / dichloromethane / 16 h / 20 °C
  • 17
  • [ 215437-47-1 ]
  • [ 1202474-13-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 10 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -70 - -65 °C 1.2: 0.42 h 1.3: 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C 2.2: 1 h 3.1: triethylamine / dichloromethane / 16 h / 20 °C 4.1: trifluoroacetic acid / 48 h / 20 °C 5.1: N-iodo-succinimide / N,N-dimethyl-formamide / 3 h / 65 °C 6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C 7.1: water; sodium hydroxide / ethanol / 1 h / 20 °C 8.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C 9.1: potassium carbonate / acetonitrile / 2 h / 20 °C 10.1: copper(l) iodide / tris-(dibenzylideneacetone)dipalladium(0); triphenyl-arsane / N,N-dimethyl-formamide / 1.5 h / 90 °C / Inert atmosphere
  • 18
  • [ 215437-47-1 ]
  • [ 1202473-66-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 11 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -70 - -65 °C 1.2: 0.42 h 1.3: 20 °C 2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C 2.2: 1 h 3.1: triethylamine / dichloromethane / 16 h / 20 °C 4.1: trifluoroacetic acid / 48 h / 20 °C 5.1: N-iodo-succinimide / N,N-dimethyl-formamide / 3 h / 65 °C 6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C 7.1: water; sodium hydroxide / ethanol / 1 h / 20 °C 8.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C 9.1: potassium carbonate / acetonitrile / 2 h / 20 °C 10.1: copper(l) iodide / tris-(dibenzylideneacetone)dipalladium(0); triphenyl-arsane / N,N-dimethyl-formamide / 1.5 h / 90 °C / Inert atmosphere 11.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C
  • 19
  • O-benzyl S-prop-2-yn-1-yl carbonodithioate [ No CAS ]
  • [ 4214-79-3 ]
  • [ 215437-47-1 ]
  • 20
  • [ 100-51-6 ]
  • [ 215437-47-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / 5.5 h / Ambient temperature 2: toluene / Heating
  • 21
  • [ 215437-47-1 ]
  • tert-butyl 4-(6-hydroxypyridin-3-yl)piperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos / toluene / 110 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / methanol / 25 °C / 760.05 Torr
  • 22
  • [ 215437-47-1 ]
  • 5-(piperazin-1-yl)pyridin-2-ol hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos / toluene / 110 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / methanol / 25 °C / 760.05 Torr 3: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 25 °C
  • 23
  • [ 215437-47-1 ]
  • tert-butyl 2-(2-(4-(6-hydroxypyridin-3-yl)piperazin-1-yl)-6-(1H-indazol-1-yl)-9H-purin-9-yl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos / toluene / 110 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / methanol / 25 °C / 760.05 Torr 3: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 25 °C 4: triethylamine / dimethyl sulfoxide / 100 °C / Inert atmosphere
  • 24
  • [ 215437-47-1 ]
  • 2-(2-(4-(6-hydroxypyridin-3-yl)piperazin-1-yl)-6-(1H-indazol-1-yl)-9H-purin-9-yl)acetic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos / toluene / 110 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / methanol / 25 °C / 760.05 Torr 3: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 25 °C 4: triethylamine / dimethyl sulfoxide / 100 °C / Inert atmosphere 5: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
  • 25
  • [ 215437-47-1 ]
  • [ 57260-71-6 ]
  • [ 861884-70-0 ]
YieldReaction ConditionsOperation in experiment
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos In toluene at 110℃; Inert atmosphere; 129.2 Step 2: To a solution of 2-(benzyloxy)-5-chloropyridine (1.5 g, 6.85 mmol, 1.0 eq) in toluene (15 mL) under nitrogen atmosphere was added NaOtBu (1.98 g, 20.55 mmol, 3.0 eq), 1-Boc-piperazine (1.53 g, 8.22 mmol, 1.2 eq), X-phos (0.65 g, 1.37 mmol, 0.2 eq) and Pd2(dba)3 (0.63 g, 0.69 mmol, 0.1 eq). The mixture was stirred at 110°C overnight before it was allowed to cool and concentrated. The residue was diluted with water (30 mL) and extracted with EtOAc (3 x 30 mL). The combined organic layer was washed with brine, dried over NaiSCL, and concentrated. The crude residue was purified by flash column chromatography on silica gel (petroleum ether:EtOAc=5: l) to give of tert-butyl 4-(6- (benzyloxy)pyridin-3-yl)piperazine-l-carboxylate (0.8 g, 32 % yield) as an oil.
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 215437-47-1 ]

Aryls

Chemical Structure| 177743-07-6

[ 177743-07-6 ]

2-(Benzyloxy)-3-chloropyridine

Similarity: 0.93

Chemical Structure| 1346707-11-6

[ 1346707-11-6 ]

4-Chloro-2-((4-chlorobenzyl)oxy)pyridine

Similarity: 0.91

Chemical Structure| 1346707-10-5

[ 1346707-10-5 ]

4-Chloro-2-((3-chlorobenzyl)oxy)pyridine

Similarity: 0.89

Chemical Structure| 1006052-55-6

[ 1006052-55-6 ]

2-(Benzyloxy)-4-chloropyridine

Similarity: 0.89

Chemical Structure| 1033202-56-0

[ 1033202-56-0 ]

3-Chloro-2-(4-methoxybenzyloxy)pyridine

Similarity: 0.88

Chlorides

Chemical Structure| 177743-07-6

[ 177743-07-6 ]

2-(Benzyloxy)-3-chloropyridine

Similarity: 0.93

Chemical Structure| 1346707-11-6

[ 1346707-11-6 ]

4-Chloro-2-((4-chlorobenzyl)oxy)pyridine

Similarity: 0.91

Chemical Structure| 1346707-10-5

[ 1346707-10-5 ]

4-Chloro-2-((3-chlorobenzyl)oxy)pyridine

Similarity: 0.89

Chemical Structure| 1006052-55-6

[ 1006052-55-6 ]

2-(Benzyloxy)-4-chloropyridine

Similarity: 0.89

Chemical Structure| 1033202-56-0

[ 1033202-56-0 ]

3-Chloro-2-(4-methoxybenzyloxy)pyridine

Similarity: 0.88

Ethers

Chemical Structure| 177743-07-6

[ 177743-07-6 ]

2-(Benzyloxy)-3-chloropyridine

Similarity: 0.93

Chemical Structure| 1346707-11-6

[ 1346707-11-6 ]

4-Chloro-2-((4-chlorobenzyl)oxy)pyridine

Similarity: 0.91

Chemical Structure| 1346707-10-5

[ 1346707-10-5 ]

4-Chloro-2-((3-chlorobenzyl)oxy)pyridine

Similarity: 0.89

Chemical Structure| 1006052-55-6

[ 1006052-55-6 ]

2-(Benzyloxy)-4-chloropyridine

Similarity: 0.89

Chemical Structure| 1033202-56-0

[ 1033202-56-0 ]

3-Chloro-2-(4-methoxybenzyloxy)pyridine

Similarity: 0.88

Related Parent Nucleus of
[ 215437-47-1 ]

Pyridines

Chemical Structure| 177743-07-6

[ 177743-07-6 ]

2-(Benzyloxy)-3-chloropyridine

Similarity: 0.93

Chemical Structure| 1346707-11-6

[ 1346707-11-6 ]

4-Chloro-2-((4-chlorobenzyl)oxy)pyridine

Similarity: 0.91

Chemical Structure| 1346707-10-5

[ 1346707-10-5 ]

4-Chloro-2-((3-chlorobenzyl)oxy)pyridine

Similarity: 0.89

Chemical Structure| 1006052-55-6

[ 1006052-55-6 ]

2-(Benzyloxy)-4-chloropyridine

Similarity: 0.89

Chemical Structure| 1033202-56-0

[ 1033202-56-0 ]

3-Chloro-2-(4-methoxybenzyloxy)pyridine

Similarity: 0.88