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[ CAS No. 216529-53-2 ] {[proInfo.proName]}

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Chemical Structure| 216529-53-2
Chemical Structure| 216529-53-2
Structure of 216529-53-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 216529-53-2 ]

CAS No. :216529-53-2 MDL No. :MFCD04114382
Formula : C14H13NO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 211.26 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 216529-53-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 216529-53-2 ]

[ 216529-53-2 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 216529-53-2 ]
  • [ 1538-08-5 ]
  • [ 216504-41-5 ]
YieldReaction ConditionsOperation in experiment
Step 3 Preparation of 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridine A mixture of 3-(4'-pyridylacetyl)toluene (2.11 g, 0.01 mol) and <strong>[1538-08-5]trifluoroacetyl hydrazide</strong> (step 2) (1.0 g, 0.01 mol) was heated at 200 C. under N2 for 15 minutes. The crude residue was purified by chromatography (silica gel, 35:65 ethyl acetate/hexane) to give 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridine (0.56 g) as a white solid: m.p. 237-239 C. Anal. Calc'd for C16H12F3N3: C, 63.36; H, 3.99; N, 13.85. Found: C, 63.6; H, 4.00; N, 13.70.
at 200℃; for 0.25h; Step 3: Preparation of 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridine A mixture of 3-(4'-pyridylacetyl)toluene (2.11 g, 0.01 mol) and <strong>[1538-08-5]trifluoroacetyl hydrazide</strong> (step 2) (1.0 g, 0.01 mol) was heated at 200 C. under N2 for 15 minutes. The crude residue was purified by chromatography (silica gel, 35:65 ethyl acetate/hexane) to give 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridine (0.56 g) as a white solid: m.p. 237-239 C. Anal. Calc'd for C16H12F3N3: C, 63.36; H, 3.99; N, 13.85. Found: C, 63.6; H, 4.00; N, 13.70.
  • 3
  • [ 216529-53-2 ]
  • [ 1538-08-5 ]
  • [ 216504-41-5 ]
  • 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-4-y1]pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Step 3 Preparation of 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridine A mixture of 3-(4'-pyridylacetyl)toluene (2.11 g, 0.01 mol) and <strong>[1538-08-5]trifluoroacetyl hydrazide</strong> (step 2) (1.0 g, 0.01 mol) was heated at 200 C. under N2 for 15 minutes. The crude residue was purified by chromatography (silica gel, 35:65 ethyl acetate/hexane) to give 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridine (0.56 g) as a white solid: m.p. 237-239 C. Anal. Calc'd for C16H12F3N3: C, 63.36; H, 3.99; N, 13.85. Found: C, 63.6; H, 4.00; N, 13.70.
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