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[ CAS No. 21717-95-3 ]

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Chemical Structure| 21717-95-3
Chemical Structure| 21717-95-3
Structure of 21717-95-3 * Storage: {[proInfo.prStorage]}

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Product Details of [ 21717-95-3 ]

CAS No. :21717-95-3 MDL No. :MFCD04114135
Formula : C5H5FN2 Boiling Point : 171°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :112.11 g/mol Pubchem ID :2762809
Synonyms :

Safety of [ 21717-95-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P305+P351+P338 UN#:N/A
Hazard Statements:H302-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 21717-95-3 ]

  • Upstream synthesis route of [ 21717-95-3 ]
  • Downstream synthetic route of [ 21717-95-3 ]

[ 21717-95-3 ] Synthesis Path-Upstream   1~9

  • 1
  • [ 246847-98-3 ]
  • [ 21717-95-3 ]
YieldReaction ConditionsOperation in experiment
90.2% With ammonium hydroxide; palladium on activated charcoal; hydrogen In methanol In 1000ml single neck flask of 2-amino-3-fluoro-5-chloropyridine (50g, 0.341mol) was dissolved in methanol (600ml) was added aqueous ammonia (50ml), with hydrogen in the Pd (2.5g, 23.5mmol) under catalytic reduction, the reaction was completed, filtration to remove Pd / C, and the filter cake washed with methanol, the filtrate concentrated under reduced pressure to give a white solid crude, the crude dissolved in water, (200ml * 4) and extracted with ethyl acetate, the organic layer was collected with anhydrous NaSO4Sulfate, and concentrated under reduced pressure, a small amount of petroleum ether beating, suction filtration to give white crystals 34.50g, 90.20percent yield.
Reference: [1] Patent: CN105669539, 2016, A, . Location in patent: Paragraph 0061; 0062; 0063
  • 2
  • [ 1513-66-2 ]
  • [ 21717-95-3 ]
Reference: [1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 41, p. 7564 - 7567
  • 3
  • [ 67-63-0 ]
  • [ 939-48-0 ]
  • [ 21717-95-3 ]
YieldReaction ConditionsOperation in experiment
34 %Chromat. at 75℃; for 6 h; Different 03- and 05-substituted directing group were found to be suitable for the Zn(OAc)2.17H20- catalysed directed cleavage of I with iPrOH (lOa). Both electron-withdrawing (F, Cl, 000R, NO2, ON,OF3) and electron-donating (Alkyl, Ph, OR) groups in 03- and 05-position of the py-DG were evaluated (Example Table E2).
Reference: [1] Patent: WO2017/46133, 2017, A1, . Location in patent: Page/Page column 51; 53
  • 4
  • [ 628322-77-0 ]
  • [ 21717-95-3 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 6, p. 1518 - 1522
  • 5
  • [ 17282-04-1 ]
  • [ 21717-95-3 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 6, p. 1518 - 1522
  • 6
  • [ 21717-95-3 ]
  • [ 17157-48-1 ]
  • [ 139022-26-7 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 6, p. 1518 - 1522
  • 7
  • [ 21717-95-3 ]
  • [ 1321612-85-4 ]
Reference: [1] Patent: WO2013/123444, 2013, A1, . Location in patent: Page/Page column 209; 210
  • 8
  • [ 21717-95-3 ]
  • [ 1211590-31-6 ]
Reference: [1] Patent: WO2013/101974, 2013, A1,
[2] Patent: US9617268, 2017, B2,
  • 9
  • [ 21717-95-3 ]
  • [ 1532517-95-5 ]
Reference: [1] Patent: WO2017/133701, 2017, A1,
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