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Chemical Structure| 220620-09-7 Chemical Structure| 220620-09-7

Structure of Tigecycline
CAS No.: 220620-09-7

Chemical Structure| 220620-09-7

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Tigecycline (GAR-936) functions as a broad-spectrum glycylcycline antibiotic, with an approximate mean inhibitory concentration (MIC) of 125 ng/mL against E. coli (MG1655 strain). It exhibits MIC50 and MIC90 values of 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively.

Synonyms: GAR-936; Glycylcycline

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Product Citations

Product Citations

Shabbir, Sanya ; Hadi, Abdullah ; Jabeen, Nusrat ; Hussain, Mushtaq ;

Abstract: Antibiotics are the major therapeutic arsenal against bacterial infections. Yet, beneath this medical triumph lies an under investigated challenge of the potential teratological and toxicological impacts associated with the use of antibiotics. In the present study, we have explored the teratogenic potential of five commonly used antibiotics (streptomycin, metronidazole, , doxycycline and norfloxacin) on Drosophila melanogaster Oregon-R strain. Except , all other tested antibiotics significantly delayed the onset of pupariation. Consistently, metronidazole, doxycycline and resulted in statistically significant drops in egg-toadult viability and adversely affected egg-to-pupa transition. In comparison, embryonic exposure of streptomycin impeded pupa-to-fly transition. All tested antibiotics induced morphological defects in antenna, wings, proboscis, eye, head, thorax, haltere and abdomen. Interestingly, developmental exposure of antibiotics resulted in statistically significant decrease in the lifespan of both male and female flies. This suggests an increased incidence of teratogenic faults at the systemic level, which are otherwise not manifested morphologically, due to the exposure of tested antibiotics during development. Taken together, our data show that developmental exposure of antibiotics may induce varying degrees of teratogenicity in D. melanogaster. Given the genomic homology and conservation of major molecular pathways that underpin development in humans and D. melanogaster, the findings do hold translational potential.

Keywords: Antibiotics ; Drosophila melanogaster ; Development ; Teratogenicity ; Lifespan

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Product Details of Tigecycline

CAS No. :220620-09-7
Formula : C29H39N5O8
M.W : 585.65
SMILES Code : O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])CC4=C(C(C3=C(O)[C@@]21O)=O)C(O)=C(NC(CNC(C)(C)C)=O)C=C4N(C)C)N
Synonyms :
GAR-936; Glycylcycline
MDL No. :MFCD00935753
InChI Key :SOVUOXKZCCAWOJ-HJYUBDRYSA-N
Pubchem ID :54686904

Safety of Tigecycline

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H317-H318-H360-H400-H411
Precautionary Statements:P201-P202-P261-P272-P273-P280-P302+P352-P305+P351+P338+P310-P308+P313-P333+P313-P391-P405-P501
Class:9
UN#:3077
Packing Group:

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01332786 Acute Myeloid Leukemia PHASE1 COMPLETED 2025-01-15 University of California, Los ... More >>Angeles, Los Angeles, California, 90095, United States|The University of Kansas Medical Center, Kansas City, Kansas, 66160, United States|Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada Less <<
NCT00419991 Staphylococcal Infections PHASE4 COMPLETED 2025-05-08 CPL Associates Investigational... More >> Site, Huntsville, Alabama, 35801, United States|CPL Associates Investigational Site, Marietta, Georgia, 30060, United States|CPL Associates Investigational Site, Cumberland, Maryland, 21502, United States Less <<
NCT01401023 Diarrhea|Clostridium Difficile COMPLETED 2025-07-13 Michigan State University, Eas... More >>t Lansing, Michigan, 48824, United States|Sparrow Hosptial, Lansing, Michigan, 48912, United States Less <<
NCT00488761 Skin Diseases, Infectious PHASE4 COMPLETED 2025-08-07 Multiple Cities, Taiwan
NCT00079976 Gram-Positive Bacterial Infect... More >>ions|Staphylococcus Infections|Vancomycin Resistance|Methicillin Resistance Less << PHASE3 COMPLETED 2025-06-05 -
NCT00376324 Healthy Subjects PHASE1 COMPLETED 2025-10-08 Phoenix, Arizona, 85006, Unite... More >>d States Less <<
NCT00827541 Intra-Abdominal Infections|Ski... More >>n Disease, Infectious|Soft Tissues Infections Less << COMPLETED 2025-12-10 -
NCT02931526 Bacterial Infection|Critically... More >> Ill Less << UNKNOWN - Zhujiang Hospital,Southern Med... More >>ical University, Guangzhou, Guangdong, 510282, China Less <<
NCT00081744 Gram-Positive Bacterial Infect... More >>ions|Cross Infection Less << PHASE3 COMPLETED 2025-08-04 -
NCT00205816 Bacterial Infections PHASE3 COMPLETED 2025-11-05 Heidelberg, D-69120, Germany|G... More >>dansk, 80-952, Poland|Poznan, 60-355, Poland Less <<
NCT04937894 Infectious Disease RECRUITING 2025-12-01 Wei Zhao, Jinan, Shandong, Chi... More >>na Less <<
NCT00600600 Mycobacterium Abscessus Lung D... More >>isease|Rapidly Growing Mycobacterial Lung Disease Less << PHASE2 COMPLETED 2025-12-10 The University of Texas Health... More >> Science Center at Tyler, Tyler, Texas, 75708, United States Less <<
NCT01560143 Obesity PHASE4 COMPLETED 2025-05-12 Albany College of Pharmacy, Al... More >>bany, New York, 12186, United States Less <<
NCT01342731 Antibiotic Resistant Infection PHASE4 UNKNOWN 2025-12-12 Siriraj Hospital, Bangkok, 107... More >>00, Thailand Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.71mL

0.34mL

0.17mL

8.54mL

1.71mL

0.85mL

17.08mL

3.42mL

1.71mL

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