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[ CAS No. 220904-92-7 ] {[proInfo.proName]}

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Chemical Structure| 220904-92-7
Chemical Structure| 220904-92-7
Structure of 220904-92-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 220904-92-7 ]

CAS No. :220904-92-7 MDL No. :MFCD06213022
Formula : C9H10N2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 162.19 Pubchem ID :-
Synonyms :

Safety of [ 220904-92-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 220904-92-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 220904-92-7 ]

[ 220904-92-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 61394-50-1 ]
  • [ 220904-92-7 ]
YieldReaction ConditionsOperation in experiment
With hydrogen at 20℃; for 24h; 10.A A. A slurry of 5-cyanoindolin-2-one (5 g, 31.64 mmol) and 10% palladium on carbon (500 mg), was hydrogenated under 40 psi at ambient temperature temp. for 24 hours. Filtration through a pad of celite and concentration afforded 5-aminomethylindolin-2-one (5.5 g) as an orange oil.
With hydrogenchloride; hydrogen In methanol for 72h; 24.C Step C: 5-Aminomethyl-1,3-dihydro-indol-2-one; A solution of the compound obtained in Step B (35 mmoles) in MeOH (500 ml) is added to 6 ml of concentrated HCl. The reaction mixture is stirred for 3 days under 10 bars of hydrogen. After filtration over Celite, the filtrate is evaporated to dryness to yield the title product in the form of a white powder, which is used directly in the next reaction.
  • 2
  • [ 61394-50-1 ]
  • [ 220904-92-7 ]
  • 5-Aminomethyl-3-(3,5-dibromo-4-hydroxy-benzylidene)-1,3-dihydro-indol-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
In acetic acid 25.a 5-Aminomethyloxindole Example 25a 5-Aminomethyloxindole A slurry of 5-cyanooxindole (1.0 g, 6.3 mmol) and 10 palladium on carbon (0.05 g) in glacial acetic acid (50 mL) at room temperature was hydrogenated under 40 psi pressure for 24 hours. The catalyst was removed by filtration through a pad of diatomaceous earth and the solvent evaporated from the filtrate to leave an orange oil of 5-aminomethyloxindole as an acetate salt (1.16 g). 1H NMR (DMSO-d6) δ7.21 (s, 1H), 7.14 (d, 1H, J=7.6 Hz), 6.75 (d, 1H, J=7.6 Hz), 3.74 (s, 2H), 3.44 (s, 2H). MS (+ve ES) 146 (100), (M-NH2).
  • 3
  • [ 220904-92-7 ]
  • [ 5617-74-3 ]
  • (1R,5S)-3-(2-oxo-2,3-dihydro-1H-indol-5-ylmethyl)-3-aza-bicyclo[3.1.0]-hexane-2,4-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
With acetic acid; for 48h;Reflux; Step D: (1R,5S)-3-(2-oxo-2,3-dihydro-1H-indol-5-ylmethyl)-3-aza-bicyclo[3.1.0]-hexane-2,4-dione; A solution of the compound obtained in Step C (15 mmoles) and 3-oxa-bicyclo[3.1.0]-hexane-2,4-dione (22.5 mmoles) in acetic acid (60 ml) is heated at reflux for 48 hours. The mixture is brought to ambient temperature and the solid formed is filtered off to yield the title product, which is used directly in the next reaction.Mass spectrometry (ES+, m/z): 257.0913 (M+H)+
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