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[ CAS No. 221221-00-7 ] {[proInfo.proName]}

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Chemical Structure| 221221-00-7
Chemical Structure| 221221-00-7
Structure of 221221-00-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 221221-00-7 ]

CAS No. :221221-00-7 MDL No. :MFCD12924862
Formula : C7H5BrF2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 223.02 Pubchem ID :-
Synonyms :

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 221221-00-7 ]

[ 221221-00-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 221220-99-1 ]
  • [ 74-88-4 ]
  • [ 221221-00-7 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate In dichloromethane; acetone P.C 3-Methoxy-2,4-difluoro-bromobenzene 3-Methoxy-2,4-difluoro-bromobenzene A quantity of 3.7 g of 3-hydroxy-2,4-difluoro-bromobenzene is dissolved in 25 ml of acetone and 2.5 g of potassium carbonate is added followed by 2.2 ml of methyl iodide. The mixture is stirred at 20° C. for 6 hours and the solvent evaporated. After addition of dichloromethane, the suspension is filtered. Evaporation of the solvent affords the desired product.
With potassium carbonate In acetone at 20℃; for 6h; EXAMPLE C 3-Methoxy-2,4-difluoro-bromobenzene 3-Methoxy-2,4-difluoro-bromobenzene A quantity of 3.7 g of 3-hydroxy-2,4-difluoro-bromobenzene is dissolved in 25 ml of acetone and 2.5 g of potassium carbonate is added followed by 2.2 ml of methyl iodide.. The mixture is stirred at 20° C. for 6 hours and the solvent evaporated.. After addition of dichloromethane, the suspension is filtered.. Evaporation of the solvent affords the desired product.
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 20h; Cooling with ice; D-8 4-bromo-1-methyl-1H-pyrazolo[3,4-c]pyridine General procedure: To a mixture of 4-bromo-1H-pyrazolo[3,4-c]pyridine (CAS: 1032943-43-3) (262 mg), cesium carbonate (863 mg) and DMF (6.5 mL) was added dropwise methyl iodide (CAS: 74-88-4) (0.107 mL) under ice-cooling. The mixture was stirred at room temperature for 20 hr, water was added to the reaction solution under ice-cooling, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure, and the residue was subjected to silica gel column chromatography (chloroform/methanol) to give the title compound (160 mg) as an oil. 1H-NMR (CDCl3) δ: 4.21 (3H, s), 8.06 (1H, s), 8.40 (1H, s), 8.89 (1H, s). MS (m/z): 212, 214 (M+H)+.
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