Alternatived Products of [ 221622-80-6 ]
Product Details of [ 221622-80-6 ]
CAS No. : | 221622-80-6 |
MDL No. : | MFCD06246209 |
Formula : |
C8H6ClFO2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
188.58
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 221622-80-6 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 221622-80-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 221622-80-6 ]
- 1
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[ 221622-80-6 ]
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[ 20291-99-0 ]
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tert-butyl 5-chloro-6-methoxybenzo[b]thiophene-2-carboxylate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Stage #1: 5-chloro-2-fluoro-4-methoxybenzaldehyde; t-butyl mercaptoacetate With caesium carbonate In 1,4-dioxane for 6h; Reflux;
Stage #2: In 1,4-dioxane at 20℃; for 1h; |
28.1 Step 1: tert-butyl 5-chloro-6-methoxybenzo[b]thiophene-2-carboxylate
To a mixture of 134 5-chloro-2-fluoro-4-methoxybenzaldehyde (0.055 g, 0.3 mmol), 46 Cs2CO3 (0.49 g, 1.5 mmol), and 165 dioxane (1.5 mL) was added 219 tert-butyl 2-mercaptoacetate (0.053 g, 0.36 mmol). The reaction was heated at reflux for 6 h. After 6 h, the mixture was allowed to cool to rt and then diluted with dioxane (2.0 mL). Macroporous 301 polystyrene-bound isocyanate (1.59 mmol/g-0.50 g) was added, and the reaction was shaken at rt for 1 h. After 1 h, the mixture was filtered, washed with dioxane and concentrated under reduced pressure to afford a crude mixture containing tert-butyl 5-chloro-6-methoxybenzo[b]thiophene-2-carboxylate that was taken on to the next step without further purification or characterization |