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[ CAS No. 221622-80-6 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 221622-80-6
Chemical Structure| 221622-80-6
Structure of 221622-80-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 221622-80-6 ]

CAS No. :221622-80-6 MDL No. :MFCD06246209
Formula : C8H6ClFO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 188.58 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 221622-80-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 221622-80-6 ]

[ 221622-80-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 221622-80-6 ]
  • [ 20291-99-0 ]
  • tert-butyl 5-chloro-6-methoxybenzo[b]thiophene-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: 5-chloro-2-fluoro-4-methoxybenzaldehyde; t-butyl mercaptoacetate With caesium carbonate In 1,4-dioxane for 6h; Reflux; Stage #2: In 1,4-dioxane at 20℃; for 1h; 28.1 Step 1: tert-butyl 5-chloro-6-methoxybenzo[b]thiophene-2-carboxylate To a mixture of 134 5-chloro-2-fluoro-4-methoxybenzaldehyde (0.055 g, 0.3 mmol), 46 Cs2CO3 (0.49 g, 1.5 mmol), and 165 dioxane (1.5 mL) was added 219 tert-butyl 2-mercaptoacetate (0.053 g, 0.36 mmol). The reaction was heated at reflux for 6 h. After 6 h, the mixture was allowed to cool to rt and then diluted with dioxane (2.0 mL). Macroporous 301 polystyrene-bound isocyanate (1.59 mmol/g-0.50 g) was added, and the reaction was shaken at rt for 1 h. After 1 h, the mixture was filtered, washed with dioxane and concentrated under reduced pressure to afford a crude mixture containing tert-butyl 5-chloro-6-methoxybenzo[b]thiophene-2-carboxylate that was taken on to the next step without further purification or characterization
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