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Chemical Structure| 2222138-31-8 Chemical Structure| 2222138-31-8

Structure of Sotuletinib HCl
CAS No.: 2222138-31-8

Chemical Structure| 2222138-31-8

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Sotuletinib is a highly selective, brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing over 1000-fold selectivity against other receptor tyrosine kinases, suitable for research on neurodegenerative diseases and tumor microenvironments.

Synonyms: BLZ945 hydrochloride

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Product Details of Sotuletinib HCl

CAS No. :2222138-31-8
Formula : C20H23ClN4O3S
M.W : 434.94
SMILES Code : O=C(NC)C1=NC=CC(OC2=CC=C3N=C(N[C@H]4[C@H](O)CCCC4)SC3=C2)=C1.[H]Cl
Synonyms :
BLZ945 hydrochloride
MDL No. :N/A

Safety of Sotuletinib HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of Sotuletinib HCl

RTK

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Biological Activity

Description
Sotuletinib (BLZ945) hydrochloride acts as a potent, selective, and brain-penetrating inhibitor of CSF-1R (c-Fms), demonstrating an IC50 of 1 nM. It exhibits over 1,000-fold selectivity compared to its nearest receptor tyrosine kinase relatives[1].

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