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Chemical Structure| 2226664-93-1 Chemical Structure| 2226664-93-1

Structure of KY19382
CAS No.: 2226664-93-1

Chemical Structure| 2226664-93-1

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KY19382 is an orally active dual inhibitor targeting CXXC5-DVL and GSK3β, capable of activating the Wnt/β-catenin signaling pathway, showing potential in metabolic disease research.

Synonyms: A3051

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Product Details of KY19382

CAS No. :2226664-93-1
Formula : C17H11Cl2N3O2
M.W : 360.19
SMILES Code : O=C1NC=2C=C(Cl)C(Cl)=CC2C1=C3NC=4C=CC=CC4C3=NOC
Synonyms :
A3051
MDL No. :MFCD32878265

Safety of KY19382

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362

Related Pathways of KY19382

PI3K-AKT
Hedgehog

Isoform Comparison

Biological Activity

Description
KY19382 is a potent dual inhibitor of CXXC5-DVL and GSK3β, exhibiting IC50s of 19 and 10 nM, respectively. It activates Wnt/β-catenin signaling by inhibiting both the CXXC5-DVL interaction and GSK3β activity. KY19382 is suitable for investigating high fat diet (HFD)-induced metabolic diseases[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.88mL

2.78mL

1.39mL

27.76mL

5.55mL

2.78mL

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