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Chemical Structure| 2227029-18-5 Chemical Structure| 2227029-18-5

Structure of TUS-007
CAS No.: 2227029-18-5

Chemical Structure| 2227029-18-5

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TUS-007, a modified CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) molecule originally derived from a proteasome inhibitor, scarcely affects proteasome activity. It is a potent, orally active degrader of KRAS G12D/V, effective in cell-free chemical knockdown of KRAS G12D/V. Furthermore, TUS-007 has been shown to suppress tumor growth

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Product Details of TUS-007

CAS No. :2227029-18-5
Formula : C44H54Cl2N8O5
M.W : 845.86
SMILES Code : O=C(NCC(N[C@@H](CC(C)C)C(NCCCCCCC(N[C@@H]([C@H](C)CC)C(NC1=CC=C2C(NC(CC3=CNC4=C3C=CC=C4)=N2)=C1)=O)=O)=O)=O)C5=CC(Cl)=CC=C5Cl
MDL No. :N/A

Safety of TUS-007

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of TUS-007

GPCR

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.18mL

0.24mL

0.12mL

5.91mL

1.18mL

0.59mL

11.82mL

2.36mL

1.18mL

 

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