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Chemical Structure| 2237268-08-3 Chemical Structure| 2237268-08-3

Structure of SBI-797812
CAS No.: 2237268-08-3

Chemical Structure| 2237268-08-3

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SBI-797812 is an effective nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NMN and NAD+ levels, improving energy metabolism. It has potential research value for enhancing cellular energy states and improving metabolic diseases.

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Product Details of SBI-797812

CAS No. :2237268-08-3
Formula : C19H22N4O4S
M.W : 402.47
SMILES Code : O=C(NCC1=CC=NC=C1)NC2=CC=C(S(=O)(N3CC(O4)CCC4C3)=O)C=C2
MDL No. :MFCD32197237

Safety of SBI-797812

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
SBI-797812 functions as an orally active activator of nicotinamide phosphoribosyltransferase (NAMPT). It induces a shift in NAMPT activity towards NMN formation, enhances NAMPT's affinity for ATP, stabilizes phosphorylated NAMPT, facilitates the consumption of pyrophosphate by-product, and attenuates feedback inhibition by NAD+. SBI-797812 leads to elevated intracellular nicotinamide mononucleotide (NMN) levels and increased liver NAD+ concentrations in mice[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.42mL

2.48mL

1.24mL

24.85mL

4.97mL

2.48mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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