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Chemical Structure| 2241237-51-2 Chemical Structure| 2241237-51-2

Structure of SRX3177
CAS No.: 2241237-51-2

Chemical Structure| 2241237-51-2

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SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4 with IC50 values of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), and 3.3 nM (CDK6). It has broad cytotoxicity against cancer cells but is non-toxic to normal epithelial cells.

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Product Details of SRX3177

CAS No. :2241237-51-2
Formula : C31H32N6O4S
M.W : 584.69
SMILES Code : O=C(C1=CC2=CN=C(NC3=CC=C(C4=CSC5=C4OC(N6CCOCC6)=CC5=O)C=C3)N=C2N1C7CCCC7)N(C)C
MDL No. :N/A

Safety of SRX3177

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of SRX3177

epigenetics
PI3K-AKT
Hedgehog

Isoform Comparison

Biological Activity

Description
SRX3177 serves as a multifaceted inhibitor targeting CDK4/6, PI3K, and BRD4, demonstrating IC50s of 33 nM for BRD4 BD1, 89 nM for BRD4 BD2, 79 nM for PI3Kα, 83 nM for PI3Kδ, 3.18 μM for PI3Kγ, less than 2.5 nM for CDK4, and 3.3 nM for CDK6. It exhibits extensive cytotoxic effects on cancerous cells while sparing normal epithelial cells[1].

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