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Chemical Structure| 2244061-66-1 Chemical Structure| 2244061-66-1

Structure of TYK2-IN-12
CAS No.: 2244061-66-1

Chemical Structure| 2244061-66-1

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TYK2-IN-12 is an orally active and selective TYK2 inhibitor that inhibits the IL-12-induced IFNγ signaling pathway, used for research on inflammatory responses related to autoimmune diseases such as psoriasis.

4.5 *For Research Use Only !

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Product Details of TYK2-IN-12

CAS No. :2244061-66-1
Formula : C24H20F2N4O2
M.W : 434.44
SMILES Code : O=C1NCC2=NC(C3=C(F)C=CC=C3F)=CC(NC4=CC=C(C(N5CCCC5)=O)C=C4)=C21
MDL No. :N/A

Safety of TYK2-IN-12

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of TYK2-IN-12

epigenetics
RTK
JAK-STAT

Isoform Comparison

Biological Activity

Description
TYK2-IN-12, an orally active, potent, and selective inhibitor of TYK2 (tyrosine kinase 2), with a Ki of 0.51 nM, inhibits IL-12-induced IFNγ, with IC50 values of 2.7 and 7.0 μM in human and mouse whole blood, respectively. It serves as a valuable tool for psoriasis research[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.51mL

2.30mL

1.15mL

23.02mL

4.60mL

2.30mL

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