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Chemical Structure| 2253123-16-7 Chemical Structure| 2253123-16-7

Structure of Pimicotinib
CAS No.: 2253123-16-7

Chemical Structure| 2253123-16-7

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Pimicotinib is a CSF1R inhibitor with anti-tumor activity.

Synonyms: ABSK021

4.5 *For Research Use Only !

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Product Details of Pimicotinib

CAS No. :2253123-16-7
Formula : C22H24N6O3
M.W : 420.46
SMILES Code : O=C(N1C(C(C)(C)CC1)=O)NC2=NC(C)=C(OC3=CC(C4=CN(C)N=C4)=NC=C3)C=C2
Synonyms :
ABSK021
MDL No. :N/A

Safety of Pimicotinib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of Pimicotinib

RTK

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT06186804 cGvHD PHASE2 ENROLLING_BY_INVITATION 2026-12-30 Peking University People's Hos... More >>pital, Beijing, Beijing, China|The Second Affiliated Hospital of the Army Medical University, Chongqing, Chongqing, China|Fujian Medical University Union Hospital, Fuzhou, Fujian, China|Guangdong Provincial Peoplep's Hospital, Guangzhou, Guangdong, China|ZhuJiang Hospital of Southern Medical University, Zhujiang, Guangdong, China|Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei, China|Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei, China|The Fir St Affiliated Hospital,Zhejiang Univer Sity School of Medicine, Hangzhou, Jiangsu, China|The First affiliated hospital of SuZhou University, Suzhou, Jiangsu, 215000, China|The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China|The First Hospital of Jilin University, Changchun, Jilin, China|West China Hospital of Sichuan University, Chengdu, Sichuan, China|Hematology Hospital of Chinese Academy of Medical Sciences, Tianjin, Tianjin, China|The First Teaching Hospital of Xinjiang Medical University, Xinjiang, Xinjiang, China Less <<
NCT04192344 Neoplasms|Tenosynovial Giant C... More >>ell Tumor Less << PHASE1 RECRUITING 2025-12-31 Precision NextGen Oncology, Be... More >>verly Hills, California, 90212, United States|SCRI at HealthOne, Denver, Colorado, 80218-1238, United States|The Winship Cancer Institute of Emory University, Atlanta, Georgia, 30322, United States|MD Anderson Cancer Center, Houston, Texas, 77030, United States|Beijing Jishuitan Hospital, Beijing, Beijing, China|The First Affiliated Hospital of Sun Yat-sen University, Guangdong, Guangzhou, China|Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China|Henan Cancer Hospital, Zhengzhou, Henan, China|The First Affiliated Hospital of Zhengzhou Universtity, Zhengzhou, Henan, China|Jiangsu Province Hospital, Nanjing, Jiangsu, China|Nanjing Drum Tower Hospital, Nanjing, Jiangsu, China|Liaoning Cancer Hospital, Shenyang, Liaoning, China|Huashan Hospital of Fudan University, Shanghai, Shanghai, China|Shanghai Sixth People's Hospital, Shanghai, Shanghai, China|Xi'an Hong Hui Hospital, Xian, Shanxi, China|West China Hospital of Sichuan University, Chengdu, Sichuan, China|The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Less <<
NCT06562946 Pharmacokinetics PHASE1 COMPLETED 2025-01-10 The first hospital of Jilin Un... More >>iversity, Changchun, Jilin, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.89mL

2.38mL

1.19mL

23.78mL

4.76mL

2.38mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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