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[ CAS No. 225517-17-9 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 225517-17-9
Chemical Structure| 225517-17-9
Structure of 225517-17-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 225517-17-9 ]

CAS No. :225517-17-9 MDL No. :MFCD26523306
Formula : C15H18F3NO7S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 413.37 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 225517-17-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 225517-17-9 ]

[ 225517-17-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 358-23-6 ]
  • [ 225517-15-7 ]
  • [ 225517-17-9 ]
YieldReaction ConditionsOperation in experiment
85% With triethylamine In dichloromethane at 0℃; for 2h;
81% In dichloromethane at 4 - 20℃; for 5h; 6.C N-tert-Butoxycarbonyl-(S)-4-(trifluoromethylsulfonyloxy)phenylglycine, Methyl Ester To a 25 mL round bottom flask fitted with a stir bar and septum was added N-tert-butyloxycarbonyl-(S)-4-hydroxyphenylglycine, methyl ester (1.9 g, 6.8 mmol) and pyridine (2.8 mL, 33 mmol) in 12 mL of methylene chloride. The flask was purged with N2, cooled to 0° and trifluoromethanesulfonic anhydride (1.38 mL, 7.8 mmol) was added dropwise over several minutes, keeping the temperature at or below 4° C. The solution was stirred for 1 h, then at room temperature for 4 h. The mixture was diluted with 20 mL of methylene chloride. The mixture was washed with 20 mL of 0.5 N NaOH, 1×20 mL of water and 2×20 mL of 10% citric acid. Dry the organic layer over MgSO4, filter, reduce the volume. Flash chromatography (75/25 hexane/methylene chloride) gave 2.3 g of desired product (81% yield). 300 MHz 1H NMR (CDCl3): δ1.43 (s, 9H), 3.74 (s, 3H), 5.35 (1H, br d), 5.68 (br s, 1H), 7.27 (d, 2H, J=8 Hz), 7.47 (d, 2H, J=8 Hz).
  • 2
  • [ 69651-48-5 ]
  • [ 225517-17-9 ]
  • 3
  • [ 32462-30-9 ]
  • [ 225517-17-9 ]
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