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Chemical Structure| 2276-90-6 Chemical Structure| 2276-90-6

Structure of Iotalamic acid
CAS No.: 2276-90-6

Chemical Structure| 2276-90-6

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Lotalamic acid is a molecule used as a contrast medium.

Synonyms: Iothalamic acid

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Product Details of Iotalamic acid

CAS No. :2276-90-6
Formula : C11H9I3N2O4
M.W : 613.91
SMILES Code : O=C(O)C1=C(I)C(C(NC)=O)=C(I)C(NC(C)=O)=C1I
Synonyms :
Iothalamic acid
MDL No. :MFCD00800738
InChI Key :UXIGWFXRQKWHHA-UHFFFAOYSA-N
Pubchem ID :3737

Safety of Iotalamic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00555321 Immunosuppression in Solid Org... More >>an Transplant Less << Phase 2 Terminated - -
NCT03168906 Amyloidosis Phase 2 Active, not recruiting July 2019 United States, Arizona ... More >> Mayo Clinic- Arizona Scottsdale, Arizona, United States, 85259 United States, California University of California San Francisco San Francisco, California, United States, 94143 United States, Florida Mayo Clinic- Florida Jacksonville, Florida, United States, 32224 United States, Massachusetts Tufts Medical Center Boston, Massachusetts, United States, 02111 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Minnesota Mayo Clinic- Minnesota Rochester, Minnesota, United States, 55905 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Pennsylvania Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Less <<
NCT00214786 - Completed - -
NCT00214786 Type 1 Diabetes Phase 1 Completed - United States, Texas ... More >> Baylor Regional Transplant Institute - Baylor University Medical Center Dallas, Texas, United States, 75246 Less <<
NCT00252187 Congestive Heart Failure ... More >> Cardiomyopathy Less << Phase 1 Phase 2 Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00555321 - Terminated - -
NCT00346151 - Terminated(Stopping rule-acute... More >> rejection threshold-was met based on local biopsy results) Less << - -
NCT01846468 Chronic Renal Insufficiency Phase 1 Completed - United States, Florida ... More >> Novartis Investigative Site Orlando, Florida, United States, 32809 United States, Tennessee Novartis Investigative Site Knoxville, Tennessee, United States, 37920 Less <<
NCT01011205 Liver Transplantation Phase 3 Completed - -
NCT00252187 - Completed - -
NCT01302899 Non-diabetic Nephropathy Phase 2 Terminated(In consequence of t... More >>ermination of ALTITUDE. A number of studies were continued in consultation with the Altitude Data Monitoring Committee.) Less << - Netherlands ... More >> Novartis Investigative Site Groningen, Netherlands Novartis Investigative Site Leeuwarden, Netherlands Less <<
NCT00346151 Renal Transplant Phase 2 Terminated(Stopping rule-acute... More >> rejection threshold-was met based on local biopsy results) Less << - United States, California ... More >> University of California, San Francisco San Francisco, California, United States, 94143 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 Less <<
NCT01302899 - Terminated(In consequence of t... More >>ermination of ALTITUDE. A number of studies were continued in consultation with the Altitude Data Monitoring Committee.) Less << - -
NCT00270634 Kidney Diseases Phase 2 Completed - -
NCT03493802 - Recruiting November 1, 2020 United States, Minnesota ... More >> Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Contact: Kathleen R Leistikow, ACRC    507-266-1316    leistikow.kathleen@mayo.edu    Contact: Charles D Madsen, CCRP    507-266-9391    madsen.charles@mayo.edu    Principal Investigator: Maria V Irazabal, M.D. Less <<
NCT00881439 Heart Failure ... More >> Kidney Failure Less << Phase 2 Terminated(Futility) - Netherlands ... More >> University Medical Center Groningen Groningen, Netherlands Less <<
NCT00543569 Kidney Transplantation Phase 2 Completed - -
NCT00617604 - Completed - -
NCT00405548 - Completed - -
NCT00426153 Polycystic Kidney, Autosomal D... More >>ominant Polycystic Liver Disease Hepatomegaly Liver Diseases Kidney, Polycystic Abdominal Pain Less << Phase 2 Phase 3 Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00543569 - Completed - -
NCT00270634 - Completed - -
NCT00426153 - Completed - -
NCT00617604 De Novo Kidney Transplantation Phase 2 Completed - -
NCT00166712 Kidney Transplant Failure and ... More >>Rejection Less << Phase 4 Terminated(Study stopped due t... More >>o lack of efficacy & funding.) Less << - United States, Illinois ... More >> Northwestern University/Northwestern Memorial Hospital Chicago, Illinois, United States, 60611 Less <<
NCT00405548 Left Ventricular Diastolic Dys... More >>function Less << Phase 1 Phase 2 Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00587418 Liver Transplant Recipients Not Applicable Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00405639 Heart Failure ... More >> Asymptomatic Systolic Dysfunction Less << Phase 1 Phase 2 Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00405639 - Completed - -
NCT01840540 Atherosclerotic Renal Artery S... More >>tenosis Ischemic Nephropathy Renovascular Hypertension Less << Phase 1 Completed - United States, Minnesota ... More >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Less <<
NCT00256750 Kidney Transplantation ... More >> Chronic Kidney Failure Less << Phase 3 Completed - -
NCT00982423 - Completed - -
NCT00166712 - Terminated(Study stopped due t... More >>o lack of efficacy & funding.) Less << - -
NCT00348556 Cardiorenal Syndrome Phase 1 Phase 2 Terminated(Company providing c... More >>atheter bought out, funding and supplies terminated) Less << - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT01936519 Immunosuppression ... More >> Renal Failure Less << Not Applicable Active, not recruiting December 2019 United States, Pennsylvania ... More >> Penn State College of Medicine; Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033 Less <<
NCT00348556 - Terminated(Company providing c... More >>atheter bought out, funding and supplies terminated) Less << - -
NCT00982423 Heart Failure ... More >> Kidney Dysfunction Less << Phase 1 Phase 2 Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00170846 - Completed - -
NCT00690014 Kidney Disease Not Applicable Completed - United States, Maryland ... More >> University of Maryland GCRC Baltimore, Maryland, United States, 21201 Less <<
NCT00170846 Renal Transplantation Phase 4 Completed - Switzerland ... More >> Novartis Basel, Switzerland Less <<
NCT00114777 Renal Transplantation Phase 3 Completed - -
NCT01336972 Autosomal Dominant Polycystic ... More >>Kidney Disease Less << Phase 2 Completed - Netherlands ... More >> University Medical Center Groningen Groningen, Netherlands, 9713 GZ Less <<
NCT01336972 - Completed - -
NCT00938561 - Withdrawn(Non availability of ... More >>funding) Less << - -
NCT00229684 Diabetes Mellitus, Type 2 Phase 2 Terminated(The development pro... More >>gram has been terminated) Less << - United States, California ... More >> Research Site Pasadena, California, United States United States, District of Columbia Research Site Washington, District of Columbia, United States United States, Florida Research Site Gainesville, Florida, United States Research Site Miami, Florida, United States Research Site Orlando, Florida, United States United States, Georgia Research Site Augusta, Georgia, United States Research Site Columbus, Georgia, United States United States, Louisiana Research Site New Orleans, Louisiana, United States United States, Nevada Research Site Reno, Nevada, United States United States, New York Research Site Flushing, New York, United States United States, North Carolina Research Site Durham, North Carolina, United States United States, Ohio Research Site Cleveland, Ohio, United States Research Site Columbus, Ohio, United States United States, Oklahoma Research Site Tulsa, Oklahoma, United States United States, Pennsylvania Research Site Cheswick, Pennsylvania, United States Research Site Philadelphia, Pennsylvania, United States United States, Tennessee Research Site Nashville, Tennessee, United States United States, Texas Research Site Midland, Texas, United States Research Site San Antonio, Texas, United States United States, Washington Research Site Gig Harbor, Washington, United States Research Site Seattle, Washington, United States Less <<
NCT00256750 - Completed - -
NCT00114777 - Completed - -
NCT01546532 Chronic Heart Failure (CHF) Phase 2 Completed - United States, Maryland ... More >> Novartis Investigative Site Baltimore, Maryland, United States Germany Novartis Investigative Site Berlin, Germany, 10117 Novartis Investigative Site Erlangen, Germany, 91054 Novartis Investigative Site Goettingen, Germany, 37075 Novartis Investigative Site Hamburg, Germany, 20246 Netherlands Novartis Investigative Site Deventer, Netherlands, 7416 SE Novartis Investigative Site Groningen, Netherlands, 9713 GZ Novartis Investigative Site Sneek, Netherlands, 8601 ZR Poland Novartis Investigative Site Grodzisk Mazowiecki, Poland, 05-825 Novartis Investigative Site Katowice, Poland, 40-637 Novartis Investigative Site Krakow, Poland, 31-202 Novartis Investigative Site Kraków, Poland, 31-501 Novartis Investigative Site Lublin, Poland, 20-954 Novartis Investigative Site Walbrzych, Poland, 58-309 Novartis Investigative Site Warszawa, Poland, 04-628 Less <<
NCT00121810 Kidney Transplantation Phase 4 Completed - -
NCT01163162 - Completed - -
NCT01163162 Chronic Kidney Disease Phase 4 Completed - United States, Indiana ... More >> Roudebush VA Medical Center Indianapolis, Indiana, United States, 46202 Less <<
NCT00830037 Chronic Kidney Disease ... More >> Iron-deficiency Anemia Less << Phase 4 Terminated(Terminated by the D... More >>SMB based on low chance of finding differences in mGFR slopes, but higher risk of serious adverse events in the IV iron group (aIRR = 1.60)) Less << - United States, Indiana ... More >> VA Medical Center Indianapolis, Indiana, United States, 46202 Less <<
NCT00121810 - Completed - -
NCT00830037 - Terminated(Terminated by the D... More >>SMB based on low chance of finding differences in mGFR slopes, but higher risk of serious adverse events in the IV iron group (aIRR = 1.60)) Less << - -
NCT01709136 Hypertension Phase 2 Phase 3 Terminated(Sirolimus usage dis... More >>continued since black box warning) Less << - -
NCT00193635 Congenital Urological Abnormal... More >>ities Less << Phase 1 Completed - United States, New Jersey ... More >> Robert Wood Johnson Medical center New Brunswick, New Jersey, United States, 08903-0019 United States, New York Schneider Children's Hospital New Hyde Park, New York, United States, 11040 Cornell Weill Medical Center New York, New York, United States, 10021-4873 Less <<
NCT01709136 - Terminated(Sirolimus usage dis... More >>continued since black box warning) Less << - -
NCT00275639 Liver Transplant Recipients Phase 4 Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT01158742 - Completed - United States, Alabama ... More >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55455 Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00255398 - Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT00472082 - Terminated(This study was term... More >>inated at the request of the drug manufacturer.) Less << - -
NCT00846729 - Completed - United States, California ... More >> Stanford University School of Medicine Stanford, California, United States, 94305 Less <<
NCT01895114 - Unknown December 2015 United States, Texas ... More >> Baylor All Saint's Medical Center in Fort Worth Recruiting Fort Worth, Texas, United States, 76104 Contact: Erin Fassett, RN,MSN,MBA    214-820-7755    Erin.Fassett@baylorhealthe.du    Contact: Michelle Acker, RN    214-820-6624    Michelle.Acker@baylorhealth.edu Less <<
NCT00286156 Polycystic Kidney Diseases Phase 1 Phase 2 Completed - United States, Ohio ... More >> The Cleveland Clinic- main campus Cleveland, Ohio, United States, 44195 Less <<
NCT00286156 - Completed - -
NCT03190070 Kidney Diseases Not Applicable Recruiting June 1, 2019 United States, Massachusetts ... More >> Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Less <<
NCT00026715 - Completed - United States, Maryland ... More >> National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Bethesda, Maryland, United States, 20892 Less <<
NCT00472082 Kidney Transplantation ... More >> Chronic Kidney Failure Less << Phase 1 Phase 2 Terminated(This study was term... More >>inated at the request of the drug manufacturer.) Less << - United States, Georgia ... More >> Emory University Atlanta, Georgia, United States, 30322 Less <<
NCT00275535 Kidney Diseases Phase 4 Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT01180101 Chronic Kidney Disease ... More >> Obesity Less << Phase 2 Phase 3 Completed - United States, Ohio ... More >> Cleveland Clinic Cleveland, Ohio, United States, 44195 Less <<
NCT01755858 Renal Artery Obstruction ... More >> Hypertension, Renovascular Ischemia Reperfusion Injury Less << Phase 1 Phase 2 Terminated - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.63mL

0.33mL

0.16mL

8.14mL

1.63mL

0.81mL

16.29mL

3.26mL

1.63mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

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