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Chemical Structure| 2289690-31-7 Chemical Structure| 2289690-31-7

Structure of MYCi361
CAS No.: 2289690-31-7

Chemical Structure| 2289690-31-7

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MYCi361 is a MYC inhibitor with Kd value of 3.2μM. It engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy.

Synonyms: NUCC-0196361

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Product Details of MYCi361

CAS No. :2289690-31-7
Formula : C26H16ClF9N2O2
M.W : 594.86
SMILES Code : OC1=C(C2=CC(C(F)(F)F)=NN2C)C=CC(OCC3=CC=C(Cl)C=C3)=C1C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Synonyms :
NUCC-0196361
MDL No. :MFCD32263412
InChI Key :CKLCWLSEYDDTCN-UHFFFAOYSA-N
Pubchem ID :139600319

Safety of MYCi361

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of MYCi361

Hedgehog

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Primary prostate cancer cells 6 μM 48 hours To evaluate the proliferation inhibition effect of MYCi361 on primary prostate cancer cells with high and low expression of circ_0057558 PMC7952531

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
NOD/SCID/IL2rg-/- (NSG) mice Patient-derived xenograft (PDX) model Intraperitoneal injection 55 mg/kg/day Once a week for 42 days To evaluate the anti-tumor effect of MYCi361 on PDX models with high and low expression of circ_0057558 PMC7952531

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.41mL

1.68mL

0.84mL

16.81mL

3.36mL

1.68mL

References

 

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