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Chemical Structure| 229005-80-5 Chemical Structure| 229005-80-5

Structure of TAK-779
CAS No.: 229005-80-5

Chemical Structure| 229005-80-5

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TAK-779 is a highly potent and selective nonpeptide CCR5 antagonist with a IC50 value of 1.4 nM in the binding assay. TAK-779 also inhibits the replication of macrophage (M)-tropic HIV-1 (Ba-L strain) in both MAGI-CCR5 cells and PBMCs with EC50 values of 1.2 and 3.7 nM, respectively.

Synonyms: Takeda 779

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Product Details of TAK-779

CAS No. :229005-80-5
Formula : C33H39ClN2O2
M.W : 531.13
SMILES Code : O=C(C1=CC2=CC(C3=CC=C(C)C=C3)=CC=C2CCC1)NC4=CC=C(C=C4)C[N+](C)(C)C5CCOCC5.[Cl-]
Synonyms :
Takeda 779
MDL No. :MFCD05662319

Safety of TAK-779

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of TAK-779

GPCR

Isoform Comparison

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1 mM

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10 mM

1.88mL

0.38mL

0.19mL

9.41mL

1.88mL

0.94mL

18.83mL

3.77mL

1.88mL

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