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Chemical Structure| 2305154-31-6 Chemical Structure| 2305154-31-6

Structure of JCN037
CAS No.: 2305154-31-6

Chemical Structure| 2305154-31-6

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JCN037 is a potent EGFR inhibitor with IC50 values of 2.49 nM, 3.95 nM and 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively. It displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.

Synonyms: JGK037

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Product Details of JCN037

CAS No. :2305154-31-6
Formula : C16H11BrFN3O2
M.W : 376.18
SMILES Code : FC1=C(Br)C=CC=C1NC2=C3C=C(OCCO4)C4=CC3=NC=N2
Synonyms :
JGK037
MDL No. :N/A
InChI Key :MTLUFWWVOINWEL-UHFFFAOYSA-N
Pubchem ID :138513760

Safety of JCN037

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501

Related Pathways of JCN037

RTK
JAK-STAT

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.29mL

2.66mL

1.33mL

26.58mL

5.32mL

2.66mL

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