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Chemical Structure| 234779-34-1 Chemical Structure| 234779-34-1

Structure of ALE-0540
CAS No.: 234779-34-1

Chemical Structure| 234779-34-1

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ALE-0540 is a nerve growth factor receptor antagonist that inhibits the binding of NGF to the TrkA receptor, showing potential for pain treatment mechanism studies.

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Product Details of ALE-0540

CAS No. :234779-34-1
Formula : C14H11N3O5
M.W : 301.25
SMILES Code : O=C1N(NCCO)C(C2=CC([N+]([O-])=O)=CC3=CC=CC1=C23)=O
MDL No. :N/A

Safety of ALE-0540

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H318-H411-H302+H312
Precautionary Statements:P270-P264-P280-P302+P352-P305+P351+P338-P310-P330-P362+P364-P403-P501
Class:9
UN#:3077
Packing Group:

Related Pathways of ALE-0540

RTK

Isoform Comparison

Biological Activity

Description
ALE-0540, a nonpeptidic small molecule, acts as a nerve growth factor receptor antagonist. It disrupts NGF binding to tyrosine kinase (Trk) A, or to both p75 and TrkA, with IC50 values of 5.88 μM and 3.72 μM, respectively. ALE-0540 is valuable in studying mechanisms underlying pain treatment development [1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.32mL

0.66mL

0.33mL

16.60mL

3.32mL

1.66mL

33.20mL

6.64mL

3.32mL

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