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Chemical Structure| 2349356-39-2 Chemical Structure| 2349356-39-2

Structure of BSJ-04-132
CAS No.: 2349356-39-2

Chemical Structure| 2349356-39-2

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BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity.

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Product Details of BSJ-04-132

CAS No. :2349356-39-2
Formula : C42H49N11O7
M.W : 819.91
SMILES Code : O=C1C=2C=CC=C(OCC(=O)NCCCCN3CCN(C4=CN=C(C=C4)NC=5N=CC=6C=C(C(=O)N(C)C)N(C6N5)C7CCCC7)CC3)C2C(=O)N1C8C(=O)NC(=O)CC8
MDL No. :MFCD33023230

Safety of BSJ-04-132

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of BSJ-04-132

Hedgehog

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.22mL

0.24mL

0.12mL

6.10mL

1.22mL

0.61mL

12.20mL

2.44mL

1.22mL

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