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Chemical Structure| 2361241-23-6 Chemical Structure| 2361241-23-6

Structure of BI-749327
CAS No.: 2361241-23-6

Chemical Structure| 2361241-23-6

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BI-749327 is a potent, highly selective, orally bioavailable TRPC6 antagonist with IC50 values of 13 nM (mouse), 19 nM (human), and 15 nM (guinea pig). It exhibits a 85-fold selectivity for mouse TRPC6 over TRPC3 and a 42-fold selectivity over TRPC7.

Synonyms: BI-749327

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Product Details of BI-749327

CAS No. :2361241-23-6
Formula : C23H21F3N4O2
M.W : 442.43
SMILES Code : O=C(N1CCC(C2=NN=C(N)C=C2)CC1)C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3
Synonyms :
BI-749327
MDL No. :MFCD32062737

Safety of BI-749327

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.26mL

0.45mL

0.23mL

11.30mL

2.26mL

1.13mL

22.60mL

4.52mL

2.26mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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