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Chemical Structure| 2369751-07-3 Chemical Structure| 2369751-07-3

Structure of G140
CAS No.: 2369751-07-3

Chemical Structure| 2369751-07-3

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G140 is a highly selective cGAS inhibitor that effectively regulates cGAS activity, making it significant for research on anti-inflammatory and immune responses.

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Product Details of G140

CAS No. :2369751-07-3
Formula : C17H16Cl2N4O2
M.W : 379.24
SMILES Code : OCC(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)=O
MDL No. :N/A

Safety of G140

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), demonstrating IC50 values of 14.0 nM for human cGAS (h-cGAS) and 442 nM for mouse cGAS (m-cGAS). It exhibits anti-inflammatory properties[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.18mL

2.64mL

1.32mL

26.37mL

5.27mL

2.64mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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