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Chemical Structure| 2375281-44-8 Chemical Structure| 2375281-44-8

Structure of NF-κΒ activator 2
CAS No.: 2375281-44-8

Chemical Structure| 2375281-44-8

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NF-κB activator 2 is a potent orally active NF-κB activator with EC50 value of 1.58 μM.

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Product Details of NF-κΒ activator 2

CAS No. :2375281-44-8
Formula : C16H11FN2O3
M.W : 298.27
SMILES Code : O=C(O)C1=CC=CC(C2=CN=C(NC3=CC=CC=C3F)O2)=C1
MDL No. :MFCD34471035
InChI Key :VGJMPWREFUKMAD-UHFFFAOYSA-N
Pubchem ID :139434520

Safety of NF-κΒ activator 2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Related Pathways of NF-κΒ activator 2

pyroptosis

Isoform Comparison

Biological Activity

Description
NF-κΒ activator 2 is a potent and orally active NF-κΒ activator with an EC50 of 1.58 μM. It induces SOD2 by enhancing NF-κΒ expression and activation. NF-κΒ activator 2 is utilized in research on amyotrophic lateral sclerosis (ALS)[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.35mL

0.67mL

0.34mL

16.76mL

3.35mL

1.68mL

33.53mL

6.71mL

3.35mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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