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[ CAS No. 23981-26-2 ] {[proInfo.proName]}

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Chemical Structure| 23981-26-2
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Product Details of [ 23981-26-2 ]

CAS No. :23981-26-2 MDL No. :MFCD18414677
Formula : C10H9NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :AUHADULCABPIFC-UHFFFAOYSA-N
M.W : 175.18 Pubchem ID :29942756
Synonyms :

Safety of [ 23981-26-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
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Application In Synthesis of [ 23981-26-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 23981-26-2 ]
  • Downstream synthetic route of [ 23981-26-2 ]

[ 23981-26-2 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 23981-26-2 ]
  • [ 49609-15-6 ]
YieldReaction ConditionsOperation in experiment
98% for 3 h; Reflux 300 mg (1.9 mmol) of 7-methoxyquinolin-2(1H)-one was dissolved in 1.1 mL of POCl3 (12 mmol) and heated at reflux for 3 h. The mixture was poured into iced water, neutralized with sat NaHCO3 and extracted with ethyl acetate. Yield 98percent.1H NMR (400 MHz, CDCl3) δ 8.01 (d, J = 8.5 Hz, 1H), 7.68 (d, J = 8.9 Hz, 1H), 7.35 (d, J = 2.4 Hz, 1H), 7.25 (d, J = 8.3 Hz, 1H), 7.20 (dd, J = 8.9, 2.5 Hz, 1H), 3.93 (s, 3H).
66% With N-ethyl-N,N-diisopropylamine; trichlorophosphate In toluene at 120℃; for 4 h; [00222] 7-methoxyquinolin-2(lH)-one (3.5 g, 20 mmol) was dissolved in toluene (80 mL), then phosphoryl trichloride (6.1 g, 40 mmol) and diisopropylethylamine (5.2 g, 40 mmol) were added to the mixture which was heated to 120 °C for 4 h, concentrated, and extracted with dichloromethane (100 mL x 2). The combined organic layers were washed with saturated sodium bicarbonate, brine, dried, concentrated under reduced pressure, and purified by flash chromatography eluting with petroleum ether: ethyl acetate (1 :5) to afford the title compound as a red solid (2.55 g, 66 percent). MS (ESI): m/z 194 [M + H]+.
Reference: [1] Patent: WO2016/130968, 2016, A1, . Location in patent: Page/Page column 183-184
[2] Patent: WO2014/85284, 2014, A1, . Location in patent: Paragraph 00222
  • 2
  • [ 326479-53-2 ]
  • [ 23981-26-2 ]
  • [ 160893-04-9 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 12, p. 1854 - 1861
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