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To 60.8 g of geniposide solution containing 22.5 g of geniposide, 35 g of a 24 wt% sodium hydroxide aqueous solution was added,And saponification was carried out by heating at 60 C. for 1.5 hours to prepare a geniposide acid solution.
With sodium hydroxide; at 60.0℃; for 2.0h;
In a 25 mL round-bottomed flask equipped with a reflux device, 388 mg (1 mmol) of geniposide and 4 mL of a 6% (mass fraction) NaOH solution were added, and the reaction was heated while stirring at 60 C. The reaction progress was followed by TLC. V (ethanol): V (methanol) = 5: 1],The reaction time is about 2 hours. After the reaction is completed, the reaction solution is evaporated to dryness to obtain Gardeniac acid.