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Chemical Structure| 2455427-91-3 Chemical Structure| 2455427-91-3

Structure of AZD0780
CAS No.: 2455427-91-3

Chemical Structure| 2455427-91-3

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PCSK9-IN-12 is a heteroaromatic compound with binding affinity to PCSK9 with a Kd value <200 nM. It can be used in research on cholesterol metabolism.

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Product Details of AZD0780

CAS No. :2455427-91-3
Formula : C20H20F2N6O2
M.W : 414.41
SMILES Code : O=C1C=CC=CN1C2=CC=C(N[C@@H]3C[C@@H](NC4=NC=C(OC(F)F)C=N4)CC3)N=C2
MDL No. :MFCD34676592

Safety of AZD0780

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT06576765 Hepatic Impairment PHASE1 COMPLETED 2024-11-08 Research Site, Hialeah, Florid... More >>a, 33014, United States|Research Site, Orlando, Florida, 32809, United States|Research Site, San Antonio, Texas, 78215, United States Less <<
NCT06592482 Renal Impairment PHASE1 RECRUITING 2025-01-20 Research Site, Lake Forest, Ca... More >>lifornia, 92630, United States|Research Site, Hialeah, Florida, 33014, United States|Research Site, Orlando, Florida, 32808, United States|Research Site, Orlando, Florida, 32809, United States|Research Site, Saint Paul, Minnesota, 55114, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.07mL

2.41mL

1.21mL

24.13mL

4.83mL

2.41mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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