Home Cart 0 Sign in  

[ CAS No. 2486-74-0 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 2486-74-0
Chemical Structure| 2486-74-0
Structure of 2486-74-0 * Storage: {[proInfo.prStorage]}

Quality Control of [ 2486-74-0 ]

Related Doc. of [ 2486-74-0 ]

SDS
Alternatived Products of [ 2486-74-0 ]
Alternatived Products of [ 2486-74-0 ]

Product Details of [ 2486-74-0 ]

CAS No. :2486-74-0 MDL No. :MFCD18409912
Formula : C9H11NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :165.19 g/mol Pubchem ID :17921342
Synonyms :

Safety of [ 2486-74-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 2486-74-0 ]

  • Downstream synthetic route of [ 2486-74-0 ]

[ 2486-74-0 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 90564-18-4 ]
  • [ 2486-74-0 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; tin
  • 2
  • [ 577-56-0 ]
  • [ 2486-74-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: alkali; sodium amalgam / Behandeln mit Salzsaeure 2: hydriodic acid; yellow phosphorus / 137 °C 3: concentrated nitric acid / Behandeln mit konz. Schwefelsaeure mit Trennung des Gemisches durch fraktionierte Krystallisation aus Wasser, Chloroform oder Benzol 4: tin; hydrochloric acid
  • 3
  • [ 3453-64-3 ]
  • [ 2486-74-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: hydriodic acid; yellow phosphorus / 137 °C 2: concentrated nitric acid / Behandeln mit konz. Schwefelsaeure mit Trennung des Gemisches durch fraktionierte Krystallisation aus Wasser, Chloroform oder Benzol 3: tin; hydrochloric acid
  • 4
  • [ 612-19-1 ]
  • [ 2486-74-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: concentrated nitric acid / Behandeln mit konz. Schwefelsaeure mit Trennung des Gemisches durch fraktionierte Krystallisation aus Wasser, Chloroform oder Benzol 2: tin; hydrochloric acid
  • 5
  • [ 1211589-24-0 ]
  • [ 2486-74-0 ]
YieldReaction ConditionsOperation in experiment
60.5% With water; lithium hydroxide In tetrahydrofuran; methanol at 20℃; for 15h; Inert atmosphere; 3 Step 3: 4-amino-2-ethyl-benzoic acid To a solution of methyl 4-amino-2-ethylbenzoate (540 mg, 3.0 mmol) in THF (5 mL) and methanol (25 mL) was added 2.0 M LiOH (3.0 mL) aqueous solution. The resultant mixture was stirred for 15 h at room temperature and then acidified to pH=5-6 with 3.0 M hydrochloric acid. The resulting suspension was filtered, the solid was washed with water and then dried to give the title compound (0.3 g, 60.5% yield) as a white solid MS (ESI, m/z): 166.0 [M+H]+.
60.5% With methanol; water; lithium hydroxide In tetrahydrofuran at 20℃; for 15h; Inert atmosphere; 3 Step 3: 4-amino-2-ethyl-benzoic acid To a solution of methyl 4-amino-2-ethylbenzoate (540 mg, 3.0 mmol) in THF (5 mL) and methanol (25 mL) was added 2.0 M LiOH (3.0 mL) aqueous solution. The resultant mixture was stirred for 15 h at room temperature and then acidified to pH=5-6 with 3.0 M hydrochloric acid. The resulting suspension was filtered, the solid was washed with water and then dried to give the title compound (0.3 g, 60.5% yield) as a white solidMS (ESI, m/z): 166.0 [M+H]+.
60.5% With water; lithium hydroxide In tetrahydrofuran; methanol at 20℃; for 15h; 3 Step 3: 4-amino-2-ethyl-benzoic acid To a solution of methyl 4-amino-2-ethylbenzoate (540 mg, 3.0 mmol) in THF (5 mL) and methanol (25 mL) was added 2.0 M LiOH (3.0 mL) aqueous solution. The resultant mixture was stirred for 15 h at room temperature and then acidified to pH=5-6 with 3.0 M hydrochloric acid. The resulting suspension was filtered, the solid was washed with water and then dried to give the title compound (0.3 g, 60.5% yield) as a white solid (0757) MS (ESI, m/z): 166.0 [M+H]+.
60.5% With water; lithium hydroxide In tetrahydrofuran; methanol at 20℃; for 15h; 3 Step 3: 4-amino-2-ethyl-benzoic acid To a solution of methyl 4-amino-2-ethylbenzoate (540 mg, 3.0 mmol) in THF (5 mL) and methanol (25 mL) was added 2.0 M LiOH (3.0 mL) aqueous solution. The resultant mixture was stirred for 15 h at room temperature and then acidified to pH=5-6 with 3.0 M hydrochloric acid. The resulting suspension was filtered, the solid was washed with water and then dried to give the title compound (0.3 g, 60.5% yield) as a white solid MS (ESI, m/z): 166.0 [M+H]+.

  • 6
  • [ 2486-74-0 ]
  • 8-chloro-3-(2,3-difluoro-4-methoxy-phenyl)imidazo[1,2-a]pyrazine [ No CAS ]
  • 4-[[3-(2,3-difluoro-4-methoxyphenyl)imidazo[1,2-a]pyrazin-8-yl]amino]-2-ethylbenzoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
72.64% With acetic acid In acetonitrile at 65℃; for 12h; Inert atmosphere; 479.2 Step 2: 4-((3-(2,3-difluoro-4-methoxyphenyl)imidazo[l,2-a]pyrazin-8-yl)amino)-2- ethylbenzoic acid A mixture of 4-amino-2-ethyl-benzoic acid (216.91 mg, 1.12 mmol, 1.1 eq) and 8-chloro-3-(2,3- difluoro-4-methoxy-phenyl)imidazo[l,2-a]pyrazine (300.0 mg, 1.01 mmol, 1 eq) in acetonitrile (6.3 mL) and acetic acid (0.700 mL) was stirred for 12 h at 65 °C. The solvent was removed in vacuo to give 4-[[3-(2,3-difluoro-4-methoxy-phenyl)imidazo[l,2-a]pyrazin-8-yl]amino]-2-ethyl- benzoic acid (400 mg, 0.940 mmol, 72.64 % yield) as an off-white solid, which was used without further purification in the next step. MS (ESI) m/z: 425.0 [M+H]+
72.64% With acetic acid In acetonitrile at 65℃; for 12h; Inert atmosphere; 158.2 Step 2: 4-((3-(2,3-difhioro-4-methoxyphenyl)imidazo[l,2-a]pyrazin-8-yl)amino)-2-ethylbenzoic acid A mixture of 4-amino-2-ethyl-benzoic acid (216.91 mg, 1.12 mmol, 1.1 eq) and 8-chloro-3-(2,3- difluoro-4-methoxy-phenyl)imidazo[l,2-a]pyrazine (300.0 mg, 1.01 mmol, 1 eq) in acetonitrile (6.3 mL) and acetic acid (0.700 mL) was stirred for 12 h at 65 °C. The solvent was removed in vacuo to give 4-[[3-(2,3-difluoro-4-methoxy-phenyl)imidazo[l,2-a]pyrazin-8-yl]amino]-2-ethyl- benzoic acid (400 mg, 0.940 mmol, 72.64 % yield) as an off-white solid, which was used without further purification in the next step. MS (ESI) m/z: 425.0 [M+H]+
72.64% With acetic acid In acetonitrile at 65℃; for 12h; 463.2 Step 2: 4-((3-(2,3-difluoro-4-methoxyphenyl)imidazo[l,2-a]pyrazin-8-yl)amino)-2- ethylbenzoic acid A mixture of 4-amino-2-ethyl-benzoic acid (216.91 mg, 1.12 mmol, 1.1 eq) and 8-chloro-3-(2,3- difluoro-4-methoxy-phenyl)imidazo[l,2-a]pyrazine (300.0 mg, 1.01 mmol, 1 eq) in acetonitrile (6.3 mL) and acetic acid (0.700 mL) was stirred for 12 h at 65 °C. The solvent was removed in vacuo to give 4-[[3-(2,3-difluoro-4-methoxy-phenyl)imidazo[l,2-a]pyrazin-8-yl]amino]-2-ethyl- benzoic acid (400 mg, 0.940 mmol, 72.64 % yield) as an off-white solid, which was used without further purification in the next step. MS (ESI) m/z: 425.0 [M+H]+
With acetic acid In acetonitrile at 65℃; for 12h; 515.2 Step 2: 4-((3-(2,3-difluoro-4-methoxyphenyl)imidazo[l,2-a]pyrazin-8-yl)amino)-2- ethylbenzoic acid A mixture of 4-amino-2-ethyl-benzoic acid (216.91 mg, 1.12 mmol, 1.1 eq) and 8-chloro-3-(2,3- difluoro-4-methoxy-phenyl)imidazo[l,2-a]pyrazine (300.0 mg, 1.01 mmol, 1 eq) in acetonitrile (6.3 mL) and acetic acid (0.700 mL) was stirred for 12 h at 65 °C. The solvent was removed in vacuo to give 4-[[3-(2,3-difluoro-4-methoxy-phenyl)imidazo[l,2-a]pyrazin-8-yl]amino]-2-ethyl- benzoic acid (400 mg, 0.940 mmol, 72.64 % yield) as an off-white solid, which was used without further purification in the next step. MS (ESI) m/z: 425.0 [M+H]+

  • 7
  • [ 2486-74-0 ]
  • cis-tert-butyl N-[3-[[4-[[3-(2,3-difluoro-4-methoxyphenyl)imidazo[1,2-a]pyrazin-8-yl]amino]-2-ethyl-benzoyl]amino]cyclobutyl]carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: acetic acid / acetonitrile / 12 h / 65 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
  • 8
  • [ 2486-74-0 ]
  • cis N-(3-aminocyclobutyl)-4-[[3-(2,3-difluoro-4-methoxyphenyl)imidazo[1,2-a]pyrazin-8-yl]amino]-2-ethylbenzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: acetic acid / acetonitrile / 12 h / 65 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C / Inert atmosphere
  • 9
  • [ 2486-74-0 ]
  • (2,5-dioxopyrrolidin-1-yl) 4-[[3-(2,3-difluoro-4-methoxy-phenyl)imidazo[1,2-a]pyrazin-8-yl]amino]-2-ethyl-benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: acetic acid / acetonitrile / 12 h / 65 °C / Inert atmosphere 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 25 °C / Inert atmosphere
Multi-step reaction with 2 steps 1: acetic acid / acetonitrile / 12 h / 65 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 25 °C
Multi-step reaction with 2 steps 1: acetic acid / acetonitrile / 12 h / 65 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 25 °C
  • 10
  • [ 2486-74-0 ]
  • N-[2-(2-aminoethoxy)ethyl]-4-[[3-(2,3-difluoro-4-methoxy-phenyl)imidazo[1,2-a]pyrazin-8-yl]amino]-2-ethyl-benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: acetic acid / acetonitrile / 12 h / 65 °C / Inert atmosphere 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 25 °C / Inert atmosphere 3: triethylamine / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere
Multi-step reaction with 3 steps 1: acetic acid / acetonitrile / 12 h / 65 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 25 °C 3: triethylamine / tetrahydrofuran / 3 h / 25 °C
Multi-step reaction with 3 steps 1: acetic acid / acetonitrile / 12 h / 65 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 25 °C 3: triethylamine / tetrahydrofuran / 3 h / 25 °C
  • 11
  • [ 2486-74-0 ]
  • methyl 2-[2-[2-[[4-[[3-(2,3-difluoro-4-methoxy-phenyl)imidazo[1,2-a]pyrazin-8-yl]amino]-2-ethyl-benzoyl]amino]ethoxy]ethylamino]acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: acetic acid / acetonitrile / 12 h / 65 °C / Inert atmosphere 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 25 °C / Inert atmosphere 3: triethylamine / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere 4: triethylamine / N,N-dimethyl-formamide / 4 h / 25 °C / Inert atmosphere
Multi-step reaction with 4 steps 1: acetic acid / acetonitrile / 12 h / 65 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 25 °C 3: triethylamine / tetrahydrofuran / 3 h / 25 °C 4: triethylamine / N,N-dimethyl-formamide / 4 h / 25 °C
Multi-step reaction with 4 steps 1: acetic acid / acetonitrile / 12 h / 65 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 25 °C 3: triethylamine / tetrahydrofuran / 3 h / 25 °C 4: triethylamine / N,N-dimethyl-formamide / 4 h / 25 °C
  • 12
  • [ 2486-74-0 ]
  • 2-((2-(2-(4-((3-(2,3-difluoro-4-methoxyphenyl)imidazo[1,2-a]pyrazin-8-yl)amino)-2-ethylbenzamido)ethoxy)ethyl)amino)acetic acid formic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: acetic acid / acetonitrile / 12 h / 65 °C / Inert atmosphere 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 3 h / 25 °C / Inert atmosphere 3: triethylamine / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere 4: triethylamine / N,N-dimethyl-formamide / 4 h / 25 °C / Inert atmosphere 5: water; sodium hydroxide / methanol / 4 h / 25 °C / Inert atmosphere
  • 13
  • [ 2486-74-0 ]
  • tert-butyl 2-(4-((3-(2,3-difluoro-4-methoxyphenyl)imidazo[1,2-a]pyrazin-8-yl)amino)-2-ethylbenzamido)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: acetic acid / acetonitrile / 12 h / 65 °C / Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.2 h / 10 °C / Inert atmosphere 2.2: 15 h / 10 °C / Inert atmosphere
Multi-step reaction with 2 steps 1.1: acetic acid / acetonitrile / 12 h / 65 °C / Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.2 h / 10 °C / Inert atmosphere 2.2: 15 h / 10 °C
Multi-step reaction with 2 steps 1.1: acetic acid / acetonitrile / 12 h / 65 °C 2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.2 h / 10 °C 2.2: 15 h / 10 °C
Multi-step reaction with 2 steps 1.1: acetic acid / acetonitrile / 12 h / 65 °C 2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.2 h / 10 °C 2.2: 15 h / 10 °C

  • 14
  • [ 2486-74-0 ]
  • 2-(4-((3-(2,3-difluoro-4-methoxyphenyl)imidazo[1,2-a]pyrazin-8-yl)amino)-2-ethylbenzamido)acetic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: acetic acid / acetonitrile / 12 h / 65 °C / Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.2 h / 10 °C / Inert atmosphere 2.2: 15 h / 10 °C / Inert atmosphere 3.1: hydrogenchloride / 1,4-dioxane / 15 h / 30 °C / Inert atmosphere
Multi-step reaction with 3 steps 1.1: acetic acid / acetonitrile / 12 h / 65 °C / Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.2 h / 10 °C / Inert atmosphere 2.2: 15 h / 10 °C 3.1: hydrogenchloride / 1,4-dioxane; water / 15 h / 30 °C / Inert atmosphere
Multi-step reaction with 3 steps 1.1: acetic acid / acetonitrile / 12 h / 65 °C 2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.2 h / 10 °C 2.2: 15 h / 10 °C 3.1: hydrogenchloride / 1,4-dioxane / 15 h / 30 °C
Multi-step reaction with 3 steps 1.1: acetic acid / acetonitrile / 12 h / 65 °C 2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.2 h / 10 °C 2.2: 15 h / 10 °C 3.1: hydrogenchloride / 1,4-dioxane / 15 h / 30 °C

  • 15
  • [ 100959-22-6 ]
  • 2,4,6-trivinylcyclotriboroxane*pyridine complex [ No CAS ]
  • [ 2486-74-0 ]
YieldReaction ConditionsOperation in experiment
1.58 g With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene at 90℃; for 2h; Inert atmosphere; 1 Step 1: methyl 4-nitro-2- vinyl-benzoate & ethyl 4-nitro-2- vinyl-benzoate A mixture of methyl 2-bromo-4-nitro-benzoate (5.2 g, 20 mmol, 1 eq), 2, 4,6- trivinyl cyclotriboroxane pyridine complex (5.78 g, 24 mmol, 1.2 eq), (1236) tetrakis(triphenylphosphine)palladium(0) (1.16 g, 1 mmol, 0.050 eq) and potassium carbonate (11.05 g, 79.99 mmol, 4 eq) in toluene (50 mL) and ethanol (50 mL) was stirred at 90 °C under nitrogen for 2 h. The mixture was filtered over Celite. The filtrate was concentrated to dryness. To the crude was added water (50 mL). The mixture was extracted with ethyl acetate (50 mL c 3). The combined organic layers were concentrated to dryness. The crude was then purified by flash column chromatography eluting 10% ethyl acetate in petrol ether to afford methyl 4-nitro- 2-vinyl-benzoate (1.58 g) as a brown oil.
  • 16
  • [ 959778-16-6 ]
  • [ 2486-74-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 25 °C 2: lithium hydroxide; water / tetrahydrofuran / 15 h / 20 °C
Historical Records

Related Functional Groups of
[ 2486-74-0 ]

Carboxylic Acids

Chemical Structure| 2486-75-1

[ 2486-75-1 ]

4-Amino-2-methylbenzoic acid

Similarity: 0.96

Chemical Structure| 5434-21-9

[ 5434-21-9 ]

4-Aminophthalic acid

Similarity: 0.96

Chemical Structure| 21339-73-1

[ 21339-73-1 ]

4-Amino-2,5-dimethylbenzoic acid

Similarity: 0.94

Chemical Structure| 52130-17-3

[ 52130-17-3 ]

3-Amino-2-methylbenzoic acid

Similarity: 0.92

Chemical Structure| 5730-78-9

[ 5730-78-9 ]

4'-Amino-[1,1'-biphenyl]-4-carboxylic acid

Similarity: 0.92

Amines

Chemical Structure| 2486-75-1

[ 2486-75-1 ]

4-Amino-2-methylbenzoic acid

Similarity: 0.96

Chemical Structure| 5434-21-9

[ 5434-21-9 ]

4-Aminophthalic acid

Similarity: 0.96

Chemical Structure| 21339-73-1

[ 21339-73-1 ]

4-Amino-2,5-dimethylbenzoic acid

Similarity: 0.94

Chemical Structure| 52130-17-3

[ 52130-17-3 ]

3-Amino-2-methylbenzoic acid

Similarity: 0.92

Chemical Structure| 5730-78-9

[ 5730-78-9 ]

4'-Amino-[1,1'-biphenyl]-4-carboxylic acid

Similarity: 0.92

Aryls

Chemical Structure| 2486-75-1

[ 2486-75-1 ]

4-Amino-2-methylbenzoic acid

Similarity: 0.96

Chemical Structure| 5434-21-9

[ 5434-21-9 ]

4-Aminophthalic acid

Similarity: 0.96

Chemical Structure| 21339-73-1

[ 21339-73-1 ]

4-Amino-2,5-dimethylbenzoic acid

Similarity: 0.94

Chemical Structure| 52130-17-3

[ 52130-17-3 ]

3-Amino-2-methylbenzoic acid

Similarity: 0.92

Chemical Structure| 5730-78-9

[ 5730-78-9 ]

4'-Amino-[1,1'-biphenyl]-4-carboxylic acid

Similarity: 0.92