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[ CAS No. 2498-50-2 ]

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Chemical Structure| 2498-50-2
Chemical Structure| 2498-50-2
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Product Details of [ 2498-50-2 ]

CAS No. :2498-50-2 MDL No. :MFCD00013001
Formula : C7H11Cl2N3 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :208.09 g/mol Pubchem ID :75626
Synonyms :

Safety of [ 2498-50-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 2498-50-2 ]

  • Upstream synthesis route of [ 2498-50-2 ]
  • Downstream synthetic route of [ 2498-50-2 ]

[ 2498-50-2 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 25412-75-3 ]
  • [ 2498-50-2 ]
YieldReaction ConditionsOperation in experiment
94.7%
Stage #1: With iron; acetic acid In ethanol; water at 60 - 80℃; for 4 h;
Stage #2: With hydrogenchloride In ethanol; water
In a three-necked flask equipped with a reflux condenser and a mechanical stirrer, 15.0 g of p-nitrobenzamidine IV prepared in Example 2,20ml of acetic acid, 45ml of water and 45ml of ethanol (V water: V ethanol = 1: 1), 60 ° C under reflux stirring to dissolve,20.3 g of iron powder (η p-nitrobenzamidine IV: η iron powder = 1: 4) was further added,Heated to 80 ° C under reflux reaction stirring 4h, filtration.Filtrate with 20percent NaOH to adjust the pH value of 11 ~ 12 after a large number of flocculent insoluble,Filtered with concentrated hydrochloric acid to adjust the pH value of 1 ~ 2, after the concentration of crystallization, the tide at 100 C under the drying,To obtain 17.9 g of p-aminobenzamidine hydrochloride I as a white solid in a yield of 94.7percent, HPLC: 99.51percent.
Reference: [1] Patent: CN104163778, 2016, B, . Location in patent: Paragraph 0056; 0057
  • 2
  • [ 873-74-5 ]
  • [ 2498-50-2 ]
Reference: [1] Patent: WO2014/64016, 2014, A1,
[2] Patent: US2014/114089, 2014, A1,
  • 3
  • [ 619-72-7 ]
  • [ 2498-50-2 ]
Reference: [1] Patent: CN104163778, 2016, B,
[2] Patent: CN104163778, 2016, B,
  • 4
  • [ 52708-02-8 ]
  • [ 2498-50-2 ]
Reference: [1] Patent: CN104163778, 2016, B,
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