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[ CAS No. 25016-12-0 ]

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Chemical Structure| 25016-12-0
Chemical Structure| 25016-12-0
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CAS No. :25016-12-0 MDL No. :MFCD00159635
Formula : C6H8N2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :124.14 g/mol Pubchem ID :847285
Synonyms :

Safety of [ 25016-12-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 25016-12-0 ]

  • Upstream synthesis route of [ 25016-12-0 ]
  • Downstream synthetic route of [ 25016-12-0 ]

[ 25016-12-0 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 25016-12-0 ]
  • [ 5775-82-6 ]
Reference: [1] Russian Journal of Organic Chemistry, 2007, vol. 43, # 11, p. 1740 - 1741
[2] Russian Journal of General Chemistry, 2007, vol. 77, # 10, p. 1821 - 1822
  • 2
  • [ 5771-02-8 ]
  • [ 68-12-2 ]
  • [ 1353569-58-0 ]
  • [ 25016-12-0 ]
YieldReaction ConditionsOperation in experiment
72% at -20 - 80℃; for 5 h; General procedure: POCl3 (0.1 mol) was added dropwise to DMF (20 mL) at 0°C. After 1h, the mixture was cooled to −20°C, and a solution of N-alkylhydrazone (0.05mol) in DMF (10mL) was added dropwise at −20°C. The mixture was stirred at −20°C for 3h and at 80°C for 2h, then cooled to ambient temperature and poured onto ice (100g). The resulting mixture was made alkaline with 30percent aq NaOH (to pH=9–10). The product was extracted with CHCl3 (3×200mL). The combined organic extracts were separated and dried over Na2SO4. The solvent was removed under reduced pressure, and the residue was distilled in vacuo.
Reference: [1] Chemistry of Heterocyclic Compounds, 2011, vol. 47, # 8, p. 1048 - 1049
[2] Tetrahedron Letters, 2014, vol. 55, # 14, p. 2187 - 2189
[3] Chemistry of Heterocyclic Compounds, 2011, vol. 47, # 8, p. 1048 - 1049
  • 3
  • [ 68-12-2 ]
  • [ 27006-76-4 ]
  • [ 25016-12-0 ]
  • [ 26990-64-7 ]
Reference: [1] Synthetic Communications, 2004, vol. 34, # 9, p. 1541 - 1550
  • 4
  • [ 694-48-4 ]
  • [ 68-12-2 ]
  • [ 25016-12-0 ]
Reference: [1] J. Gen. Chem. USSR (Engl. Transl.), 1980, vol. 50, # 10, p. 1922 - 1926[2] Zhurnal Obshchei Khimii, 1980, vol. 50, # 10, p. 2370 - 2375
  • 5
  • [ 25016-12-0 ]
  • [ 78703-53-4 ]
Reference: [1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981, vol. 30, # 4, p. 683 - 685[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981, # 4, p. 902 - 904
  • 6
  • [ 25016-12-0 ]
  • [ 78703-53-4 ]
  • [ 10505-21-2 ]
Reference: [1] Russian Chemical Bulletin, 2012, vol. 61, # 6, p. 1148 - 1153[2] Izv. Akad. Nauk, Ser. Khim., 2012, vol. 61, # 6, p. 1139 - 1143,5
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