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[ CAS No. 25021-08-3 ]

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Chemical Structure| 25021-08-3
Chemical Structure| 25021-08-3
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CAS No. :25021-08-3 MDL No. :MFCD00457254
Formula : C6H5NO4 Boiling Point : 376.7°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :155.11 g/mol Pubchem ID :319935
Synonyms :

Safety of [ 25021-08-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302+H312+H332-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 25021-08-3 ]

  • Upstream synthesis route of [ 25021-08-3 ]
  • Downstream synthetic route of [ 25021-08-3 ]

[ 25021-08-3 ] Synthesis Path-Upstream   1~5

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  • [ 6066-82-6 ]
  • [ 25021-08-3 ]
  • [ 55750-61-3 ]
Reference: [1] Bioconjugate Chemistry, 2012, vol. 23, # 12, p. 2417 - 2433
[2] Journal of Medicinal Chemistry, 1984, vol. 27, # 10, p. 1325 - 1335
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Reference: [1] Patent: CN105037237, 2017, B,
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  • [ 329709-87-7 ]
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YieldReaction ConditionsOperation in experiment
64.5% With triethylamine; 1-nitro-4-trifluoroacetoxy-benzene In dichloromethane at -5 - -2℃; for 3 h; In a 1000 ml three-necked flask,The compound of formula (II) (162 g, 0.94 mol, X = 1)And 400 ml of dichloromethane,Triethylamine (284.8 g, 2.82 mol) was then added,Ice salt was cooled to -2 ° C with stirring,Phenyl 4-nitro trifluoroacetate (353.4 g, 1.5 mol) was added dropwiseIn 300 ml of dichloromethane,Controlling the temperature below -5-10 ,Dripping finished insulation stirring 3h.The reaction solution was concentrated to dryness, 400 ml of water was added, and the pH was adjusted to 3-4 with concentrated hydrochloric acid while stirring. The 4-nitrophenol was removed by filtration and the filtrate was extracted three times with dichloromethane. The combined organic phases were washed with water and dried over anhydrous magnesium sulfate Concentrated to dryness to give a pale yellow solid 129g,Ethyl acetate, petroleum ether, mixed solvent was recrystallized to give a white solid 107g, weighed after drying 94g,HPLC purity 98.2percent, yield 64.5percent.
Reference: [1] Patent: CN105037237, 2017, B, . Location in patent: Paragraph 0059-0062
[2] Chemistry - A European Journal, 2011, vol. 17, # 2, p. 468 - 480
[3] Organic and Biomolecular Chemistry, 2009, vol. 7, # 17, p. 3400 - 3406
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  • [ 54930-24-4 ]
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Reference: [1] Bioconjugate Chemistry, 2010, vol. 21, # 1, p. 74 - 83
[2] RSC Advances, 2017, vol. 7, # 26, p. 16181 - 16188
[3] Organic and Biomolecular Chemistry, 2004, vol. 2, # 23, p. 3434 - 3441
[4] Angewandte Chemie - International Edition, 2005, vol. 44, # 41, p. 6750 - 6755
[5] Bioorganic Chemistry, 2006, vol. 34, # 6, p. 424 - 444
[6] Chemistry - A European Journal, 2006, vol. 12, # 34, p. 8798 - 8812
[7] Patent: US2006/128943, 2006, A1, . Location in patent: Page/Page column 6
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Reference: [1] Journal of Chemical Research - Part S, 1998, # 5, p. 272 - 273
[2] European Journal of Medicinal Chemistry, 2009, vol. 44, # 12, p. 5094 - 5098
[3] Organic and Biomolecular Chemistry, 2009, vol. 7, # 16, p. 3308 - 3318
[4] Organic Letters, 2010, vol. 12, # 9, p. 1920 - 1923
[5] Bioconjugate Chemistry, 2012, vol. 23, # 12, p. 2417 - 2433
[6] Patent: EP1188746, 2002, A1, . Location in patent: Page 8
[7] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 1124 - 1127
[8] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 2, p. 162 - 167
[9] Oriental Journal of Chemistry, 2018, vol. 34, # 1, p. 286 - 294
[10] Journal of Peptide Science, 2018, vol. 24, # 4-5,
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