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[ CAS No. 25055-86-1 ]

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Inaccessible (Haz class 6.1), Domestic USD 41.00
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Chemical Structure| 25055-86-1
Chemical Structure| 25055-86-1
Structure of 25055-86-1 * Storage: {[proInfo.prStorage]}

Quality Control of [ 25055-86-1 ]

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Product Details of [ 25055-86-1 ]

CAS No. :25055-86-1 MDL No. :MFCD19228230
Formula : C5H8N2O2 Boiling Point : 233.0±32.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :128.13 g/mol Pubchem ID :14248197
Synonyms :

Safety of [ 25055-86-1 ]

Signal Word:Danger Class:8
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501 UN#:1760
Hazard Statements:H302-H315-H318-H332-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 25055-86-1 ]

  • Downstream synthetic route of [ 25055-86-1 ]

[ 25055-86-1 ] Synthesis Path-Downstream   1~15

  • 1
  • [ 123-76-2 ]
  • [ 25055-86-1 ]
YieldReaction ConditionsOperation in experiment
20% (1) in anaerobic,Under nitrogen protection conditions,To a mixture of levulinic acid (2 g, 17.2 mmol)In a round bottom flask was slowly added with 7 MAmmonia methanol solution (20 mL),The reaction was carried out at 0 ° C for 3 h.Then, hydroxylamine sulfonic acid (3.24 g, 28.6 mmol) was added dropwise to the mixture, and the reaction was continued at room temperature overnight.After completion of the reaction, the white precipitate in the reaction solution was removed by filtration and washed with methanol (10 mL)Washed three times, the filtrate after steaming concentrated,Rehydrated with anhydrous methanol (20 mL) and added to the reaction flask. Triethylamine (4.3 mL, 30.9 mmol) was added at 0 ° C,And a solution of iodine (2 g, 8.0 mmol) in methanol was added dropwise,Until the reaction liquid becomes reddish brown,And keep the color unchanged within 10 min;The reaction solution was then diluted with ethyl acetate (20 mL)Washed sequentially with 1 M HCl (30 mL x 1) and saturated sodium thiosulfate solution (30 mL x 3)The organic phase was dried over anhydrous magnesium sulfate and spin dried to give the intermediate 3-(3-methyl-3H-diazirine-3-yl)propionic acid(shown by compound 1 in Figure 1)After purification by silica gel column chromatography (ethyl acetate: petroleum ether = 1: 1)The pure product of the intermediate was obtained in a yield of 20percent.
  • 3
  • [ 25055-86-1 ]
  • [ 591-80-0 ]
  • [ 33698-87-2 ]
  • [ 1617-32-9 ]
  • 4
  • [ 25055-86-1 ]
  • [ 122693-42-9 ]
  • 8
  • 3-(3-Methyldiaziridin-3-yl)propan-1-ol [ No CAS ]
  • [ 25055-86-1 ]
  • 9
  • [ 25055-86-1 ]
  • [ 25055-90-7 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; In tetrachloromethane; at 65℃; for 0.5h; DL-2-Bromo-4,4'-azi-pentanoic acid (5) EPO <DP n="37"/>The compound was obtained by bromination of 4,4'-azi-pentanoic acid according to the procedure described by Harrp et al (1975). Briefly, 4,4'-azi-pentanoic acid (Church Weiss (1970)) (3 g, 23 mmol), CCI4 (3 ml) and thionyl chloride (7 ml, 96 mmol) were heated to 650C for 30 min. N-Bromosuccinimid (4.8 g, 27 mmol), CCI4 (10 ml) and 0.1 ml of 48percent HBr were added and the mixture was stirred at 55 0C or preferably at 800C (or at any temperature between 55°C and 8O0C) for 4 h. The solvent and free bromine were removed under reduced pressure and the residue was extracted with 50 ml CCI4. The solvent was removed and the crude product (2- Bromo-4,4'-azi-pentanoyl chloride) dissolved in acetone and hydrolyzed with aq NaHCO3. The crude brominated free acid was obtained upon acidification with HCI and extraction with dichloromethane. The solvent was removed and the product filtered through silica gel in isohexane/ethyl acetate 9/1 followed by removal of the solvent. UV 3.4 mg/ml in EtOH: 342.9 nm (epsilon = 48) 1 H-NMR (CDCI3): 1.12 ppm (s, 3H, 5-CH3), 2.07 (dd, 1H, 3-CH2), 2.25 (dd, 1H, 3- CW2), 4.07 (t, 1 H1 2-CH), 10 (broad, 1 H, COOH)13C-NMR (CDCI3): 19.87 ppm (5-C), 24.09 (4-C)1 38.23 (2-C), 39.81 (3-C), 174.36 (1-C)
  • 10
  • [ 25055-86-1 ]
  • 2-bromo-4,4'-azi-pentanoyl chloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
The compound was obtained by bromination of 4,4'-azi-pentanoic acid according to the procedure described by Harrp et al (1975). Briefly, 4,4'-azi-pentanoic acid (Church Weiss (1970)) (3 g, 23 mmol), CCl4 (3 ml) and thionyl chloride (7 ml, 96 mmol) were heated to 65°C for 30 min. N-Bromosuccinimid (4.8 g, 27 mmol), CCl4 (10 ml) and 0.1 ml of 48percent HBr were added and the mixture was stirred at 55 °C for 4 h. The solvent and free bromine were removed under reduced pressure and the residue was extracted with 50 ml CCl4. The solvent was removed and the crude product (2-Bromo-4,4'-azi-pentanoyl chloride) dissolved in acetone and hydrolyzed with aq NaHCO3. The crude brominated free acid was obtained upon acidification with HCl and extraction with dichloromethane. The solvent was removed and the product filtered through silica gel in isohexane/ethyl acetate 9/1 followed by removal of the solvent. UV 3.4 mg/ml in EtOH: 342.9 nm (epsilon = 48) 1 H-NMR (CDCl3): 1.12 ppm (s, 3H, 5-CH3), 2.07 (dd, 1 H, 3-CH2), 2.25 (dd, 1 H, 3-CH'2), 4.07 (t, 1 H, 2-CH), 10 (broad, 1 H, COOH) 13C-NMR (CDCl3): 19.87 ppm (5-C), 24.09 (4-C), 38.23 (2-C), 39.81 (3-C), 174.36 (1-C)
  • 11
  • C5H10N2O2*C6H15N [ No CAS ]
  • [ 25055-86-1 ]
  • 12
  • [ 4710-95-6 ]
  • [ 25055-86-1 ]
  • ManNDAz [ No CAS ]
  • 13
  • [ 1078691-95-8 ]
  • [ 25055-86-1 ]
  • C11H19N3O6 [ No CAS ]
  • 14
  • C35H49NO3Si [ No CAS ]
  • [ 25055-86-1 ]
  • C40H55N3O4Si [ No CAS ]
  • 15
  • [ 1255731-57-7 ]
  • [ 25055-86-1 ]
Historical Records

Related Functional Groups of
[ 25055-86-1 ]

Carboxylic Acids

Chemical Structure| 1450754-37-6

[ 1450754-37-6 ]

3-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid

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