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[ CAS No. 25070-73-9 ]

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Chemical Structure| 25070-73-9
Chemical Structure| 25070-73-9
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CAS No. :25070-73-9 MDL No. :MFCD11111783
Formula : C12H15NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :221.25 g/mol Pubchem ID :12384346
Synonyms :

Safety of [ 25070-73-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 25070-73-9 ]

  • Upstream synthesis route of [ 25070-73-9 ]
  • Downstream synthetic route of [ 25070-73-9 ]

[ 25070-73-9 ] Synthesis Path-Upstream   1~8

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YieldReaction ConditionsOperation in experiment
88% at 50℃; for 0.0666667 h; Microwave irradiation; Green chemistry General procedure: Benzylcholoroformate Cbz-Cl (1 mmol) was added to amine (1 mmol) and the mixture was subjected to the microwave irradiation (100W) for the appropriate time (tables 2, 3, 4 and 5). After completion of the reaction (monitored by TLC) dichloromethane: methanol (98/2), the reaction mixture was treating with n-hexane (15–20 mL) and was allowed to stand at room temperature overnight. The solid products were collected by filtration, washed with n-hexane and dried to give the N-Cbz derivatives in good to excellent yields. During the reaction, the formation of hydrogen chloride (gas) was observed, confirming the protection of all amines structures proposal.
Reference: [1] Journal of Organic Chemistry, 2004, vol. 69, # 2, p. 577 - 580
[2] Tetrahedron Letters, 2007, vol. 48, # 1, p. 55 - 59
[3] Tetrahedron Letters, 2006, vol. 47, # 36, p. 6393 - 6396
[4] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2607 - 2610
[5] Chemistry Letters, 2010, vol. 39, # 3, p. 228 - 229
[6] Tetrahedron Letters, 2007, vol. 48, # 46, p. 8170 - 8173
[7] Canadian Journal of Chemistry, 2009, vol. 87, # 2, p. 393 - 396
[8] Synthetic Communications, 2011, vol. 41, # 18, p. 2674 - 2683
[9] Journal of the Korean Chemical Society, 2017, vol. 61, # 4, p. 151 - 156
[10] Tetrahedron Letters, 2008, vol. 49, # 32, p. 4799 - 4803
[11] Chinese Chemical Letters, 2012, vol. 23, # 7, p. 789 - 792
[12] Synthetic Communications, 2011, vol. 41, # 14, p. 2073 - 2080
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Reference: [1] RSC Advances, 2015, vol. 5, # 78, p. 63407 - 63420
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Reference: [1] Synthesis, 1986, # 8, p. 627 - 632
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Reference: [1] Bulletin of the Korean Chemical Society, 2012, vol. 33, # 5, p. 1547 - 1550
[2] Bulletin of the Korean Chemical Society, 2012, vol. 33, # 8, p. 2719 - 2723
[3] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 4, p. 1115 - 1119
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Reference: [1] Synthesis, 1986, # 8, p. 627 - 632
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Reference: [1] Journal of the American Chemical Society, 2012, vol. 134, # 47, p. 19358 - 19361
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Reference: [1] Bulletin of the Korean Chemical Society, 2012, vol. 33, # 8, p. 2719 - 2723
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Reference: [1] Bulletin of the Korean Chemical Society, 2012, vol. 33, # 8, p. 2719 - 2723
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