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[ CAS No. 25369-32-8 ]

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2D
Chemical Structure| 25369-32-8
Chemical Structure| 25369-32-8
Structure of 25369-32-8 *Storage: {[proInfo.prStorage]}

Quality Control of [ 25369-32-8 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 25369-32-8 ]

SDS

Product Details of [ 25369-32-8 ]

CAS No. :25369-32-8MDL No. :MFCD12924258
Formula :C8H8N2OBoiling Point :-
Linear Structure Formula :-InChI Key :N/A
M.W :148.16Pubchem ID :6423312
Synonyms :

Computed Properties of [ 25369-32-8 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 25369-32-8 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305 P351 P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 25369-32-8 ]

  • Downstream synthetic route of [ 25369-32-8 ]

[ 25369-32-8 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 25369-32-8 ]
  • [ 98-74-8 ]
  • [ 292635-74-6 ]
  • 2
  • [ 25369-32-8 ]
  • [ 98-68-0 ]
  • 4-methoxy-N-(2-oxo-2,3-dihydro-1H-indol-7-yl)-benzenesulfonamide [ No CAS ]
  • 3
  • [ 25369-32-8 ]
  • [ 98-59-9 ]
  • N-(1,3-Dihydro-2H-indole-2-one-7-yl)-4-methylbenzenesulfonamide [ No CAS ]
  • 4
  • [ 25369-32-8 ]
  • [ 98-60-2 ]
  • 4-chloro-N-(2-oxo-2,3-dihydro-1H-indol-7-yl)-benzenesulfonamide [ No CAS ]
  • 6
  • [ 25369-32-8 ]
  • [ 4695-57-2 ]
  • [ 1621584-47-1 ]
YieldReaction ConditionsOperation in experiment
73% In acetonitrile; at 70 - 80℃; General procedure: Oxalyl chloride (6.61mmol) was added dropwise into a stirred solution of the appropriate benzamide (2.6mmol) in CH2Cl2 (10mL). The mixtures were heated at reflux for 20-22h. Then, solvents were evaporated in vacuo to give the respective crude benzoyl isocyanates 4a-k, which were used immediately in the next step without purification. Aminoindolin-2-one (2.8mmol) was added into a stirred solution of the appropriate benzoyl isocyanate (2.8mmol) in acetonitrile (10mL). After addition, each mixture was heated at 70-80C for 2-3h. The solid products were each filtered, washed with acetonitrile, and air dried.
  • 7
  • [ 868171-67-9 ]
  • [ 25369-32-8 ]
  • 1-(4-fluorophenyl)-2-oxo-N-(2-oxoindolin-7-yl)-1,2-dihydropyridine-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; acetonitrile; at 20℃; for 3.0h; General procedure: Appropriate aminoindolin-2-one (1equiv) was added to a mixture of appropriate 3-amino-3-oxopropanoic acid/2-pyridone acid/4-pyridone acid (1equiv), TBTU (1.5equiv) and TEA (3equiv) in DMF/acetonitrile (1:3, 0.16M). The resulting reaction mixture was stirred at room temperature for 3h. Reaction mixture was then concentrated in vacuo. Title compound was collected as solid by filtration and dried.
  • 8
  • [ 25369-32-8 ]
  • [ 5416-93-3 ]
  • [ 1236291-28-3 ]
  • 9
  • [ 25369-32-8 ]
  • [ 1795-48-8 ]
  • [ 1168721-29-6 ]
YieldReaction ConditionsOperation in experiment
61% With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20℃; To a suspension of [25369-32-8]7-aminoindolin-2-one (60 mg, 0.41 mmol) in THF (3 mL) was added DIPEA (0.28 mL, 1.62 mmol), and 2-isocyanatopropane (0.05 mL, 0.49 mmol). The mixture was stirred at rt overnight then filtered. The filter cake was washed with diethyl ether to give the title compound as a pale solid (57.3 mg, 61%). 1H NMR (400 MHz, CD3OD) delta 7.09-7.04 (m, 2H), 6.99-6.95 (m, IH), 3.57 (s, 2H), 2.64 (m, IH), 1.20 (d, 6H, J = 6.4Hz). MS ESI [M + H]+, calcd for [Ci2H15N3O2 +H]+ 234.12; found m/z 234.0.
  • 10
  • [ 64-18-6 ]
  • [ 25369-32-8 ]
  • [ 1168721-33-2 ]
YieldReaction ConditionsOperation in experiment
71% With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 2.0h; To a suspension of 7-aminooxindole (32 mg, 0.22 mmol) in CH2Cl2 (1 mL) was added EDC (83 mg, 0.43 mmol) and formic acid (12 mg, 0.26 mmol). The reaction mixture was stirred at rt for 2 h and then filtered. The filter cake was washed with diethyl ether to give the title compound as a grey solid (27 mg, 71%). 1H NMR (400MHz, CD3OD) delta 8.23 (s, IH), 7.20 (d, IH, J= 8 Hz), 7.15 (d, IH, J= 8 Hz), 7.02 (t,IH, J= 8 Hz), 3.59 (s, 2H); MS ESI [M + H]+, calcd for [C9H8N2O2 +H]+ 177.07; found m/z 177.0.
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