Home Cart Sign in  
Chemical Structure| 2550393-21-8 Chemical Structure| 2550393-21-8

Structure of MS154
CAS No.: 2550393-21-8

Chemical Structure| 2550393-21-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

MS 154 is a potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon-binding moiety joined by a linker to gefitinib. MS 154 decreases EGFR protein levels, inhibits downstream signaling in and inhibits proliferation of mutant EGFR-bearing lung cancer cells (DC50 values are 11 and 25 nM in HCC-827 and H3255 cells, respectively; Dmax > 95% at 50 nM), but not in WT-EGFR-bearing ovarian and lung cancer cells lines. It is bioavailable in mice following ip administration.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of MS154

CAS No. :2550393-21-8
Formula : C46H54ClFN8O8
M.W : 901.42
SMILES Code : O=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCCCCCCCCNC(=O)CCN4CCN(CC4)CCCOC5=CC=6C(=NC=NC6NC7=CC=C(F)C(Cl)=C7)C=C5OC)C3C2=O)CC1

Safety of MS154

Related Pathways of MS154

RTK
JAK-STAT

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.11mL

0.22mL

0.11mL

5.55mL

1.11mL

0.55mL

11.09mL

2.22mL

1.11mL

 

Historical Records

Categories