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Chemical Structure| 2579689-83-9 Chemical Structure| 2579689-83-9

Structure of ML339
CAS No.: 2579689-83-9

Chemical Structure| 2579689-83-9

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ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. It antagonizes β-arrestin recruitment and cAMP signaling in human CXCR6 receptors induced by CXCL16, with IC50 values of 0.3 μM and 1.4 μM, respectively. ML339 has weaker activity against β-arrestin recruitment in mouse CXCR6 receptors, with an IC50 of 18 μM. ML339 does not inhibit CXCR5, CXCR4, CXCR6, or the Apelin receptor (APJ), with IC50 >79 μM.

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Product Details of ML339

CAS No. :2579689-83-9
Formula : C26H32ClN3O5
M.W : 502.00
SMILES Code : C(C(NC1=C(Cl)C=CC=C1)=O)N2[C@@]3(C[C@H](NC(=O)C4=CC(OC)=C(OC)C(OC)=C4)C[C@]2(CCC3)[H])[H]
MDL No. :MFCD30720892

Safety of ML339

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of ML339

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