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Chemical Structure| 2607138-82-7 Chemical Structure| 2607138-82-7

Structure of ART812
CAS No.: 2607138-82-7

Chemical Structure| 2607138-82-7

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ART812 is an inhibitor targeting DNA polymerase Polθ, used in studies of microhomology-mediated end joining (MMEJ).

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Product Details of ART812

CAS No. :2607138-82-7
Formula : C19H16ClF4N3O4
M.W : 461.79
SMILES Code : O=C([C@H]([C@H](O)[C@@H]1O)N(C2=NC(C)=CC(C(F)(F)F)=C2)C1=O)N(C3=CC=C(F)C(Cl)=C3)C
MDL No. :MFCD34602688

Safety of ART812

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of ART812

DNA

Isoform Comparison

Biological Activity

Description
ART812, an orally active inhibitor of DNA polymerase Polθ, has an IC50 of 7.6 nM. Additionally, ART812 shows an IC50 of 240 nM in cell-based microhomology-mediated end joining (MMEJ) assays [1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.65mL

4.33mL

2.17mL

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