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Chemical Structure| 2624131-45-7 Chemical Structure| 2624131-45-7

Structure of PW0787
CAS No.: 2624131-45-7

Chemical Structure| 2624131-45-7

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PW0787 is an orally bioavailable, brain-penetrant, potent, and selective GPR52 agonist.

Synonyms: PW0787

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Product Details of PW0787

CAS No. :2624131-45-7
Formula : C23H20F4N4O2
M.W : 460.42
SMILES Code : O=C(NCCO)C1=CC=CC2=C1CCN2C3=NC=NC(=C3)CC4=CC(F)=CC(=C4)C(F)(F)F
Synonyms :
PW0787
MDL No. :MFCD33550902
InChI Key :OLNVWBLTVAPNME-UHFFFAOYSA-N
Pubchem ID :155977949

Safety of PW0787

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Related Pathways of PW0787

GPCR

Isoform Comparison

Biological Activity

Description
PW0787 serves as a potent, selective, orally active, and brain-penetrant agonist of GPR52, with an EC50 of 135 nM. It suppresses psychostimulant behavior [1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.86mL

2.17mL

1.09mL

21.72mL

4.34mL

2.17mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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