[ CAS No. 262433-01-2 ]

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Product Details of [ 262433-01-2 ]

CAS No. :	262433-01-2	MDL No. :	MFCD03426369
Formula :	C₁₂H₁₆BrNO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	302.16	Pubchem ID :	-
Synonyms :

Safety of [ 262433-01-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
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Application In Synthesis of [ 262433-01-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 262433-01-2 ]
Downstream synthetic route of [ 262433-01-2 ]

[ 262433-01-2 ] Synthesis Path-Upstream 1~1

1
[ 262433-01-2 ]
[ 55860-22-5 ]

Reference： [1] Tetrahedron Letters, 1999, vol. 40, # 49, p. 8563 - 8566

[ 262433-01-2 ] Synthesis Path-Downstream 1~4

1
[ 24424-99-5 ]
[ 59557-91-4 ]
[ 262433-01-2 ]

Yield	Reaction Conditions	Operation in experiment
100%	In tetrahydrofuran; for 15h;Heating / reflux;	EXAMPLE 2 tert-butyl-N-(4-bromo-2-methoxyphenyl)carbamate 4 In a 250 ml single-necked flask placed under an inert atmosphere, 6.4 g (31.7 mmol) of <strong>[59557-91-4]4-bromo-2-methoxyaniline</strong> 2 and 7.6 g (34.9 mmol, 1.1 eq) of (Boc)2O are dissolved in 80 ml of anhydrous THF. Heat the THF under a reflux condenser for 15 hours. The medium is allowed to cool and the solvent is evaporated. The residue is taken up in CH2Cl2, washed with a saturated aqueous solution of NaHCO3 (3*). The organic phase is dried on MgSO4. A concentration under vacuum is implemented to produce a brown oil which is purified by column chromatography (eluent petroleum ether/AcOEt 9:1). 9.6 g of 4 is obtained as a colorless oil (yield: 100%). C12H16BrNO3 M=302.19 g/mol 1H NMR (CDCl3) delta (ppm): 7.95 (d, J=8.6 Hz, 1H, CH(6)); 7.07-6.94 (m, 3H, NH, CH(3), CH(5)); 3.84 (s, 3H, OCH3); 1.52 (s, 9H, CH3). 13C NMR (CDCl3) delta (ppm): 152.5 (CO2); 148.1 (C2); 127.4 (CI); 123.8 (C5); 119.1 (C6); 114.3 (C4); 113.4 (C3); 80.5 (C(CH3)3); 55.9 (OCH3); 28.3 (3C, CH3).
81.6%	In tetrahydrofuran; for 22h;Inert atmosphere; Reflux;	(0677) <strong>[59557-91-4]4-Bromo-2-methoxyaniline</strong> (6.8 g, 33.7 mmol) and di-tert-butyl dicarbonate (8.9 g, 40.8 mmol) were dissolved in tetrahydrofuran (100 mL). Under the protection of nitrogen gas, the reaction was carried out under reflux for 22 h, and the mixture was cooled. The solvent was removed by distillation under reduced pressure, and ethyl acetate (150 mL) was added. The mixture was washed with 1 mol/L hydrochloric acid, and the water phase and the organic phase were separated. The organic phase was dried with anhydrous sodium sulfate, and filtrated under suction. The filtrate was concentrated to get the title compound (8.3 g, yield: 81.6%).
80%	In tetrahydrofuran; ethyl acetate;	a) tert-Butyl N-(4-bromo-2-methoxyphenyl)carbamate. A mixture of <strong>[59557-91-4]4-bromo-2-methoxyaniline</strong> (34.0 g, 0.17 mol) and di-tert-butyl dicarbonate (44.5 g, 0.20 mol) in tetrahydrofuran (350 ml) was heated at reflux for 22 h. The mixture was allowed to cool to ambient temperature and the solvent was removed under reduced pressure. The residue was dissolved in ethyl acetate (350 ml) and washed with 1 N citric acid (200 ml), dried over magnesium sulfate, filtered and evaporated to give tert-butyl N-(4-bromo-2-methoxyphenyl)carbamate as a yellow oil (80% pure, 57.10 g, 0.15 mol): 1H NMR (DMSO-d6, 400 MHz) delta 8.01 (s, 1H), 7.63 (d, 1H), 7.17 (d, 1H), 7.07 (dd, 1H), 3.82 (s, 3H), 1.45 (s, 9H); TLC (n-heptane/ethyl acetate=2:1) Rf 0.67.

	In tetrahydrofuran; for 25h;Heating / reflux;	A mixture of Example 175A (36.4 g, 180 mmol), and di-tert-butyl dicarbonate (47.2 g, 216 mmol) in THF (500 mL) was heated to reflux for 20 hours and cooled to ambient temperature. HPLC (using the conditions from Example 175A, product Rt=13.55 min and TLC (8:2 heptane/ethyl acetate, Rf of product=0.53, Rf of <strong>[59557-91-4]4-bromo-2-methoxyaniline</strong>=0.27) indicated approximately 10% starting material was remaining. Additional di-tert-butyl dicarbonate (3.9 g, 18 mmol) was added and heating was continued for another 5 hours. The mixture was cooled and evaporated under reduced pressure. The residue was applied to a 400 gram silica gel column and eluted with 8:2 heptane/ethyl acetate. The fractions showing the desired product were combined and washed with saturated NaHCO3 and then brine. The organic solution was dried (MgSO4), filtered, and concentrated to provide 61.3 g of a mixture of the desired product and di-tert-butyl dicarbonate which was used directly in the next step
	In tetrahydrofuran; n-heptane;	EXAMPLE 175B tert-butyl 4-bromo-2-methoxyphenylcarbamate A mixture of Example 175A (36.4 g, 180 mmol), and di-tert-butyl dicarbonate (47.2 g, 216 mmol) in THF (500 mL) was heated to reflux for 20 hours and cooled to ambient temperature. HPLC (using the conditions from Example 175A, product Rt=13.55 min and TLC (8:2 heptane/ethyl acetate, Rf of product=0.53, Rf of <strong>[59557-91-4]4-bromo-2-methoxyaniline</strong>=0.27) indicated approximately 10% starting material was remaining. Additional di-tert-butyl dicarbonate (3.9 g, 18 mmol) was added and heating was continued for another 5 hours. The mixture was cooled and evaporated under reduced pressure. The residue was applied to a 400 gram silica gel column and eluted with 8:2 heptane/ethyl acetate. The fractions showing the desired product were combined and washed with saturated NaHCO3 and then brine. The organic solution was dried (MgSO4), filtered, and concentrated to provide 61.3 g of a mixture of the desired product and di-tert-butyl dicarbonate which was used directly in the next step.
	In tetrahydrofuran; for 25h;Heating / reflux;	EXAMPLE 175B tert-butyl 4-bromo-2-methoxyphenylcarbamate A mixture of Example 175A (36.4 g, 180 mmol), and di-tert-butyl dicarbonate (47.2 g, 216 mmol) in THF (500 mL) was heated to reflux for 20 hours and cooled to ambient temperature. HPLC (using the conditions from Example 175A, product Rt=13.55 min and TLC (8:2 heptane/ethyl acetate, Rf of product=0.53, Rf of <strong>[59557-91-4]4-bromo-2-methoxyaniline</strong>=0.27) indicated approximately 10% starting material was remaining. Additional di-tert-butyl dicarbonate (3.9 g, 18 mmol) was added and heating was continued for another 5 hours. The mixture was cooled and evaporated under reduced pressure. The residue was applied to a 400 gram silica gel column and eluted with 8:2 heptane/ethyl acetate. The fractions showing the desired product were combined and washed with saturated NaHCO3 and then brine. The organic solution was dried (MgSO4), filtered, and concentrated to provide 61.3 g of a mixture of the desired product and di-tert-butyl dicarbonate which was used directly in the next step.
14.7 g	In tetrahydrofuran; at 40℃; for 5h;	10.0 g (0.049 mol) of <strong>[59557-91-4]4-bromo-2-methoxyaniline</strong> in a three-necked flask,Take 13.0 g (0.060 mol) of di-tert-butyl dicarbonate,It was dissolved in tetrahydrofuran.After reacting for 5 hours at 40 C., the solvent is distilled off and represented by the formula (K-1)14.7 g of compound was obtained.

Reference： [1]Patent: US2004/58933,2004,A1 .Location in patent: Page/Page column 5
[2]Patent: US2017/112833,2017,A1 .Location in patent: Paragraph 0678-0679
[3]Patent: US2003/187001,2003,A1
[4]Tetrahedron Letters,1999,vol. 40,p. 8563 - 8566
[5]Patent: US2005/20619,2005,A1 .Location in patent: Page 40
[6]Patent: US2005/26944,2005,A1
[7]Patent: US2005/43347,2005,A1 .Location in patent: Page/Page column 49
[8]Patent: JP5888544,2016,B2 .Location in patent: Paragraph 0117; 0118

2
[ 73183-34-3 ]
[ 262433-01-2 ]
[ 262433-02-3 ]

Yield	Reaction Conditions	Operation in experiment
83%	With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	20.3 (3) Preparation of tert-butyl (2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amino carboxylate (0679) Tert-butyl (4-bromo-2-methoxyphenyl)amino carboxylate (5.0 g, 16.56 mmol), bis(pinacolato)diboron (5.05 g, 19.88 mmol) and potassium acetate (4.88 g, 49.80 mmol) were added to N,N-dimethylformamide (100 mL). Under the protection of nitrogen gas, [1,1′-bis(diphenyphosphino)ferrocene]dichloropalladium ( II) dichloromethane complex (410 mg, 0.50 mmol) was added. The mixture was heated to 80° C. and reacted overnight. After cooling to room temperature, water and dichloromethane were added, and the water phase and the organic phase were separated. The organic phase was washed with saturated saline solution for 3 times, dried with anhydrous sodium sulfate, and concentrated. The crude product was purified by silica gel column chromatography (petroleum ether:ethyl acetate=100:1) to get the title compound (4.8 g, yield: 83.0%).
65%	With potassium acetate; triethylamine In n-heptane; dichloromethane; N,N-dimethyl-formamide	1.b N1-[4-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]-4-cyano-1-benzenesulfonamide b) tert-Butyl N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-carbamate. A mixture of tert-butyl N-(4-bromo-2-methoxyphenyl)carbamate (80% pure) (6.25 g, 16.56 mmol), diboron pinacol ester (5.05 g, 19.88 mmol), [1,1'-bis(diphenylphosphino) ferrocene]dichloropalladium(II) complex with dichloromethane (1:1) (0.41 g, 0.50 mmol) and potassium acetate (4.88 g, 49.80 mmol) in N,N-dimethylformamide (100 ml) was heated at 80° C. under an atomospher of nitrogen overnight. The mixture was allowed to cool to ambient temperature and then most of the solvent was removed under reduced pressure. Dichloromethane (100 ml) was added to the residue and the resulting solids were removed by filtration through a pad of celite. The filtrate was concentrated to leave a dark oil which was purified by flash column chromatography on silica using dichloromethane/n-heptane (1:2) with 2.5% triethylamine as mobile phase to give tert-butyl N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate as white solids (65% pure, 4.25 g, 7.92 mmol): 1H NMR (DMSO-d6, 400 MHz) δ 7.93(s, 1H), 7.83 (d, 1H), 7.25 (d, 1H), 7.16 (s, 1H), 3.83 (s, 3H), 1.46 (s, 9H), 1.30(s, 12H); RP-HPLC (Hypersil C18, 5 μm, 200 A, 25 cm; 50%-100% acetonitrile-0.1M ammonium acetate over 25 min, 1 ml/min) Rt 18.28 min.
60.3%	With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate In N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere;	6.2 (2) (2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)phenyl)carbamic acid tert-butyl ester preparation A solution of tert-butyl (4-bromo-2-methoxyphenyl) carbamate (2.5 g, 8.3 mmol)Boronic acid pinacol ester (2.32 g, 9.1 mmol)And potassium acetate (1.63 g, 16.6 mmol) were added to N, N-dimethylformamide (100 mL)(Diphenylphosphine) ferrocene palladium dichloride dichloromethane complex (410 mg, 0.50 mmol) was added under nitrogen atmosphere,The reaction was allowed to proceed for 16 hours at 80 ° C,The organic phase was washed three times with saturated brine, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 100: 1) to give the title compound To give the title compound (1.75 g, yield 60.3%).

	With potassium acetate at 80℃; for 16h;	175.C EXAMPLE 175C; tert-butyl 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate A mixture of Example 175B (61.3 g, 203 mmol), 4,4,4',4',5,5,5',5'-octamethyl-2,2?-bi-1,3,2-dioxaborolane (51.6 g, 203 mmol), [1.1'-bis(diphenylphosphino)ferrocene]dichloropalladium (HI) complex with dichloromethane (1:1) (3.2 g, 3.9 mmol), and potassium acetate (59.7 g, 609 mmol) in DMF (1.0 L) was heated to 80 C. under an atmosphere of nitrogen for 16 hours, cooled to ambient temperature, and concentrated. Dichloromethane (500 mL) was added to the residue and the resulting solid was removed by filtration through a pad of diatomaceous earth (Celite). The pad was washed with dichloromethane (4?50 mL) and the combined filtrates were concentrated, applied to a 550 gram silica gel column, and quickly eluted with heptane/ethyl acetate (85:15) The fractions showing product [Rt with conditions described in Example 175A=14.33 minutes, Rf of product=0.33 TLC (85:15 heptane/ethyl acetate), Rf of tert-butyl N-(4-bromo-2-methoxyphenyl)carbamate=0.48]. This material was treated with heptane (300 mL) and stirred at ambient temperature for 30 minutes. The mixture was cooled to about 5 C. for 3 hours and the resulting precipitate was collected by filtration to provide 24.4 g of the desired product. The filtrate was evaporated and the residue was purified by flash chromatography on a 400 gram silica gel column with 9:1 heptane/ethyl acetate to give an additional 8.8 g of the desired product.
	With potassium acetate In n-heptane; dichloromethane; N,N-dimethyl-formamide	175.C tert-butyl 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate EXAMPLE 175C tert-butyl 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate A mixture of Example 175B (61.3 g, 203 mmol), 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi-1,3,2-dioxaborolane (51.6 g, 203 mmol), [1.1'-bis(diphenylphosphino)ferrocene]dichloropalladium (II) complex with dichloromethane (1:1) (3.2 g, 3.9 mmol), and potassium acetate (59.7 g, 609 mmol) in DMF (1.0 L) was heated to 80° C. under an atmosphere of nitrogen for 16 hours, cooled to ambient temperature, and concentrated. Dichloromethane (500 mL) was added to the residue and the resulting solid was removed by filtration through a pad of diatomaceous earth (Celite). The pad was washed with dichloromethane (4*50 mL) and the combined filtrates were concentrated, applied to a 550 gram silica gel column, and quickly eluted with heptane/ethyl acetate (85:15) The fractions showing product [Rt with conditions described in Example 175A=14.33 minutes, Rf of product=0.33 TLC (85:15 heptane/ethyl acetate), Rf of tert-butyl N-(4-bromo-2-methoxyphenyl)carbamate=0.48]. This material was treated with heptane (300 mL) and stirred at ambient temperature for 30 minutes. The mixture was cooled to about 5° C. for 3 hours and the resulting precipitate was collected by filtration to provide 24.4 g of the desired product. The filtrate was evaporated and the residue was purified by flash chromatography on a 400 gram silica gel column with 9:1 heptane/ethyl acetate to give an additional 8.8 g of the desired product.
	With potassium acetate In N,N-dimethyl-formamide at 80℃; for 16h;	175.C tert-butyl 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate EXAMPLE 175C tert-butyl 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate A mixture of Example 175B (61.3 g, 203 mmol), 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi-1,3,2-dioxaborolane (51.6 g, 203 mmol), [1.1'-bis(diphenylphosphino)ferrocene]dichloropalladium (II) complex with dichloromethane (1:1) (3.2 g, 3.9 mmol), and potassium acetate (59.7 g, 609 mmol) in DMF (1.0 L) was heated to 80° C. under an atmosphere of nitrogen for 16 hours, cooled to ambient temperature, and concentrated. Dichloromethane (500 mL) was added to the residue and the resulting solid was removed by filtration through a pad of diatomaceous earth (Celite). The pad was washed with dichloromethane (4*50 mL) and the combined filtrates were concentrated, applied to a 550 gram silica gel column, and quickly eluted with heptane/ethyl acetate (85:15) The fractions showing product [Rt with conditions described in Example 175A=14.33 minutes, Rf of product=0.33 TLC (85:15 heptane/ethyl acetate), Rf of tert-butyl N-(4-bromo-2-methoxyphenyl)carbamate=0.48]. This material was treated with heptane (300 mL) and stirred at ambient temperature for 30 minutes. The mixture was cooled to about 5° C. for 3 hours and the resulting precipitate was collected by filtration to provide 24.4 g of the desired product. The filtrate was evaporated and the residue was purified by flash chromatography on a 400 gram silica gel column with 9:1 heptane/ethyl acetate to give an additional 8.8 g of the desired product.

Reference： [1]Current Patent Assignee: SIHUAN PHARMACEUTICAL HOLDINGS GROUP LTD. - US2017/112833, 2017, A1 Location in patent: Paragraph 0678-0679
[2]Current Patent Assignee: ABBVIE INC - US2003/187001, 2003, A1
[3]Current Patent Assignee: SIHUAN PHARMACEUTICAL HOLDINGS GROUP LTD. - CN105884695, 2016, A Location in patent: Paragraph 0360; 0361; 0362
[4]Current Patent Assignee: ABBVIE INC - US2005/20619, 2005, A1 Location in patent: Page 40
[5]Current Patent Assignee: ABBVIE INC - US2005/26944, 2005, A1
[6]Current Patent Assignee: ABBVIE INC - US2005/43347, 2005, A1 Location in patent: Page/Page column 49

3
[ 262433-01-2 ]
[ 844891-04-9 ]
tert-butyl N-[2-methoxy-4-(1,3,5-trimethylpyrazol-4-yl)phenyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; at 100℃; for 0.333333h;Sealed tube; Microwave irradiation;	(a) tert-Butyl N-[2-methoxy-4-(1 ,3 .5-trimethyl pyrazol-4-yl)phenyl]carbamate(a) tert-Butyl N-[2-methoxy-4-(1 ,3 .5-trimethyl pyrazol-4-yl)phenyl]carbamateA mixture of tert-butyl N-(4-bromo-2-methoxy-phenyl)carbamate (150 mg, 0.5 mmcl), 1 ,35-trimethyl-4-(4,4, 5, 5-tetramethyl-I 3,2-dioxaborolan-2-yl)pyrazole (118 mg 0.5 mmcl),tetrakis(tri-phenylphosphine)palladium(0) (58 mg, 0.05 mmol) and potassium carbonate (207 mg, 1.5 mmcl) in dioxane (4 mL) was heated at 100 C under microwave irradiation for 20 minutes in a sealed tube. After cooling to ambient temperature, the mixture was concentrated and the residue was diluted with ethyl acetate, washed with water and brine, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by columnchromatography (heptane/ethyl acetate = 100/0 to 25/75 v/v%) to afford tert-butyl N-[2- methoxy-4-( I, 3,5-trimethylpyrazol-4-yl)phenyl]carbamate (126.8 mg, 77 %).
77%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; at 100℃; for 0.333333h;Microwave irradiation;	A mixture of tert-butyl N-(4-bromo-2-methoxy-phenyl)carbamate (150 mg, 0.5mmol), <strong>[844891-04-9]1,3,5-trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole</strong> (118 mg, 0.5 mmol), tetrakis(tri-phenylphosphine)palladium(0) (58 mg, 0.05 mmol) and potassium carbonate (207 mg, 1.5 mmol) in dioxane (4 mL) was heated at 100 C under microwave irradiation for 20 minutes in a sealed tube. After cooling to ambient temperature, the mixture was concentrated and the residue was diluted with ethyl acetate, washed withwater and brine, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (heptane/ethyl acetate = 100/0 to 25/75 v/v%) to afford tert-butyl N- [2-methoxy-4-(1,3,5-trimethylpyrazol-4-yl)phenyl]carbamate (126.8 mg, 77 %).

Reference： [1]Patent: WO2015/155042,2015,A1 .Location in patent: Page/Page column 33
[2]Patent: WO2016/166255,2016,A1 .Location in patent: Page/Page column 36; 37

4
[ 262433-01-2 ]
[ 844891-04-9 ]
2-methoxy-4-(1,3,5-trimethylpyrazol-4-yl)aniline [ No CAS ]

Reference： [1]Patent: WO2015/155042,2015,A1
[2]Patent: WO2016/166255,2016,A1

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P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 262433-01-2 ]

Quality Control of [ 262433-01-2 ]

Related Doc. of [ 262433-01-2 ]

Product Details of [ 262433-01-2 ]

Safety of [ 262433-01-2 ]

Application In Synthesis of [ 262433-01-2 ]

[ 262433-01-2 ] Synthesis Path-Upstream 1~1

[ 262433-01-2 ] Synthesis Path-Downstream 1~4

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry