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[ CAS No. 26304-51-8 ]

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Chemical Structure| 26304-51-8
Chemical Structure| 26304-51-8
Structure of 26304-51-8 * Storage: {[proInfo.prStorage]}

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Product Details of [ 26304-51-8 ]

CAS No. :26304-51-8 MDL No. :MFCD00225365
Formula : C12H13NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :203.24 g/mol Pubchem ID :593963
Synonyms :

Safety of [ 26304-51-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 26304-51-8 ]

  • Downstream synthetic route of [ 26304-51-8 ]

[ 26304-51-8 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 26304-51-8 ]
  • [ 74-89-5 ]
  • 3-methyl-indole-2-carboxylic acid methylamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With methanol at 100℃;
  • 3
  • [ 26304-51-8 ]
  • [ 14750-19-7 ]
YieldReaction ConditionsOperation in experiment
93% With water; Selectfluor In acetonitrile at 20℃;
36% With acetic acid; thallium(III) nitrate for 3.5h; Ambient temperature;
With sulfuryl dichloride; acetic acid Behandeln des Reaktionsprodukts mit H2O;
  • 5
  • [ 67-56-1 ]
  • [ 26304-51-8 ]
  • [ 106262-51-5 ]
YieldReaction ConditionsOperation in experiment
98% With magnesium at 10℃; for 2.5h;
  • 6
  • [ 26304-51-8 ]
  • [ 98-88-4 ]
  • [ 78593-49-4 ]
YieldReaction ConditionsOperation in experiment
95% With thallium (I) ethoxide In benzene
  • 7
  • [ 26304-51-8 ]
  • [ 75-03-6 ]
  • [ 78593-47-2 ]
YieldReaction ConditionsOperation in experiment
65% With thallium (I) ethoxide In benzene Heating;
  • 8
  • [ 26304-51-8 ]
  • [ 75-36-5 ]
  • [ 78593-48-3 ]
YieldReaction ConditionsOperation in experiment
90% With thallium (I) ethoxide In benzene
  • 9
  • [ 26304-51-8 ]
  • [ 74-88-4 ]
  • [ 61838-90-2 ]
YieldReaction ConditionsOperation in experiment
90.4% Stage #1: ethyl 3-methyl-indole-2-carboxylate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 5h;
89.9% Stage #1: ethyl 3-methyl-indole-2-carboxylate With sodium hydride In N,N-dimethyl-formamide for 2h; Stage #2: methyl iodide In N,N-dimethyl-formamide 3.2 Step 2:
Preparation of ethyl 1,3-dimethyl-1H-indole-2-carboxylate
The product of the above step (1.3 g, 6.4 mmol) was dissolved in 10 mL of dry DMF, sodium hydrogen (184 mg, 7.68 mmol) was added, and after stirred for 2 h, iodomethane (448 μl, 7.68 mmol) was added and the reaction was continued until complete. 40 mL of water and ethyl acetate (3*50 mL) was added for extraction. The combined organic layer was washed with water (3*30 mL) and saturated NaCl solution (50 mL), dried over anhydrous Na2SO4 and filtered. The solvent was removed under reduced pressure, and the residue was isolated and purified by flash column chromatography (petroleum ether / ethyl acetate = 6/1, v / v) to afford the subject product 1.25 g, yield 89.9%. MS (ESI, m/z): 218(M +H)+.
80% With thallium (I) ethoxide In benzene Heating;
  • 10
  • [ 26304-51-8 ]
  • [ 126400-15-5 ]
YieldReaction ConditionsOperation in experiment
74% With pyridine; hydrazine hydrate for 2h; Heating;
  • 11
  • [ 5439-83-8 ]
  • [ 26304-51-8 ]
YieldReaction ConditionsOperation in experiment
84% With perchloric acid; hydrogen In ethanol at 50℃; for 3h;
  • 12
  • [ 94527-29-4 ]
  • [ 26304-51-8 ]
YieldReaction ConditionsOperation in experiment
40% With triethyl phosphite at 170℃; for 3h;
  • 13
  • [ 26304-51-8 ]
  • [ 107-14-2 ]
  • [ 126718-09-0 ]
YieldReaction ConditionsOperation in experiment
79% With sodium hydride In N,N-dimethyl-formamide 1) 60 deg C - 65 deg C, 2) r.t.;
  • 14
  • (2-acetyl-phenylamino)-(diethoxy-phosphoryl)-acetic acid ethyl ester [ No CAS ]
  • [ 26304-51-8 ]
YieldReaction ConditionsOperation in experiment
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 20℃;
  • 15
  • [ 17507-56-1 ]
  • [ 551-93-9 ]
  • [ 26304-51-8 ]
YieldReaction ConditionsOperation in experiment
84% Stage #1: ethyl 2-diazo-2-(diethoxyphosphoryl)acetate; 2-aminoacetophenone With dirhodium tetraacetate In toluene at 80℃; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 20℃; Further stages.;
  • 16
  • 3-methyl-3<i>H</i>-indole-3-carboxylic acid ethyl ester [ No CAS ]
  • [ 26304-51-8 ]
  • [ 10590-73-5 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride In 1,4-dioxane at 110℃; for 6h;
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