Home Cart Sign in  
Chemical Structure| 27113-22-0 Chemical Structure| 27113-22-0

Structure of Paradol
CAS No.: 27113-22-0

Chemical Structure| 27113-22-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site, it's a pungent phenolic substance isolated and purified from ginger and other Zingiberaceae plants.

Synonyms: [6]-Paradol; [6]-Gingerone; 6-Paradol

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Vikky Awasthi ; Yash Gupta ; Rubika Chauhan ; Prakasha Kempaiah ; Jyoti Das ;

Abstract: Background: Plasmodium falciparum (P.f.)has developed resistance to most of the drugs that are being used currently. The continued search for a new drug is required to successfully eliminate the parasite. A pathway that is unique to the parasite is an ideal target to inhibit the growth of the parasite without affecting the host metabolism. Purpose: In this study, Zingiber officinale Roscoe (Zingiberaceae)(Z.o.) extract, used ethnobotanically as a potent antimicrobial, was found to inhibit P.f. in vitro. Methods: To find the active compounds that may target the essential proteins of the P.f., the known secondary metabolite constituents of Z.o. rhizome were subjected to a preliminary in-silico target search. Chorismate synthase (CS) came up as a hit with a high binding score through multiple screening strategies. The antimalarial activity of the Z.o. extracts were tested with CS downstream metabolic products i.e. aromatic amino acids. The antimalarial targetablity of CS was confirmed with the phylogenetic conservancy, protein modeling, validation and subjected to High throughput virtual screening (HTVS) with a complete secondary metabolite library of Z.o. Among the top hits, the second hit 6-paradol (1-(4‑hydroxy-3-methoxyphenyl)decan-3-one) was available as a nature-identical synthetic compound. Compound 6-paradol was further analyzed for antimalarial and cytotoxic profiles and subjected to the same CS downstream product supplementation rescue assay. Results: 6-paradol is a highly potent antimalarial and a major component of Z.o. secondary metabolite pool. Though it is predicted to bind to the active site of chorismate synthase along with other metabolites of Z.o., an enzyme, part of the shikimate pathway involved in the aromatic amino acid synthesis. Parasite growth was rescued upon supplementation of aromatic amino acids along with crude Z.o. extract in parasite culture and a shift in IC50 of > 2 folds was observed, confirming the CS as the primary target of Z.o. crude extract. However, the rescue was inconsequential when we assayed with pure 6-paradol. Conclusion: This approach exploits natural compounds with high specificity and potency to kill pathogens developed due to eons of co-evolution with related pathogens. We report a novel potent antimalarial 6-paradol with nano-molar range IC50 already approved by FDA for human consumption as a nature-identical flavoring agent with immediate repurposing potential as an anti-malarial. However, CS rescue assay failure point to a different mechanism of action by active compounds and highlights Z.o. as a treasure trove of more potent anti-malarial which need further exploration.

Keywords: Malaria ; Plasmodium ; Ginger ; Chorismate synthase

Purchased from AmBeed:

Alternative Products

Product Details of Paradol

CAS No. :27113-22-0
Formula : C17H26O3
M.W : 278.39
SMILES Code : CCCCCCCC(CCC1=CC=C(O)C(OC)=C1)=O
Synonyms :
[6]-Paradol; [6]-Gingerone; 6-Paradol
MDL No. :MFCD01736103
InChI Key :CZNLTCTYLMYLHL-UHFFFAOYSA-N
Pubchem ID :94378

Safety of Paradol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.59mL

0.72mL

0.36mL

17.96mL

3.59mL

1.80mL

35.92mL

7.18mL

3.59mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories