[ CAS No. 2714-87-6 ] {[proInfo.proName]}

Name: 2714-87-6|[1,1'-Biphenyl]-4-carbonyl fluoride|97%
Brand: Ambeed
SKU: A1443042
Price: 39.0 USD
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Quality Control of [ 2714-87-6 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 2714-87-6 ]

CAS No. :	2714-87-6	MDL No. :	MFCD29066211
Formula :	C₁₃H₉FO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	LBBFCPWRSLIXNI-UHFFFAOYSA-N
M.W :	200.21	Pubchem ID :	85772725
Synonyms :

Safety of [ 2714-87-6 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P332+P313-P362-P403+P233-P405-P501	UN#:	3261
Hazard Statements:	H315-H318-H335	Packing Group:	Ⅱ
GHS Pictogram:

Application In Synthesis of [ 2714-87-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 2714-87-6 ]

[ 2714-87-6 ] Synthesis Path-Downstream 1~50

1
[ 1591-31-7 ]
[ 2714-87-6 ]
[ 398-36-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: copper / dimethyl sulfoxide / 12 h / 60 °C / Inert atmosphere 2: potassium carbonate / methanol; water / 2 h / 20 °C / Inert atmosphere 3: xenon fluoride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

Reference： [1]Mizuta, Satoshi; Stenhagen, Ida S.R.; O'Duill, Miriam; Wolstenhulme, Jamie; Kirjavainen, Anna K.; Forsback, Sarita J.; Tredwell, Matthew; Sandford, Graham; Moore, Peter R.; Huiban, Mickael; Luthra, Sajinder K.; Passchier, Jan; Solin, Olof; Gouverneur, Véronique [Organic Letters, 2013, vol. 15, # 11, p. 2648 - 2651]

2
[ 73789-98-7 ]
[ 2714-87-6 ]
[ 398-36-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium carbonate / methanol; water / 2 h / 20 °C / Inert atmosphere 2: xenon fluoride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3
[ 73790-13-3 ]
[ 2714-87-6 ]
[ 398-36-7 ]

Yield	Reaction Conditions	Operation in experiment
1: 23 %Spectr. 2: 11 %Spectr.	With xenon fluoride In dichloromethane at 20℃; for 0.5h; Inert atmosphere;

4
[ 92-92-2 ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
94%	With sodium flouride; N-(difluoro-λ⁴-sulfanylidene)-N-ethylethanaminium tetrafluoroborate In ethyl acetate at 20℃; for 24h; Inert atmosphere;
92%	With dmap; trifluoromethyl trifluoromethanesulfonate In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Schlenk technique;
73%	With [bis(2-methoxyethyl)amino]-sulfur trifluoride In dichloromethane at 0℃; for 0.0833333h; Inert atmosphere;	1-3. Procedures of preparation of acyl fluoride 1 General procedure: Method AS3: Under N2 atmosphere, the corresponding carboxylic acid (3.00 mmol) was transferredto a PFA bottle equipped with a stirrer bar. After addition of CH2Cl2 (5.00 mL) to the bottle, the reactionmixture was cooled at 0 °C in ice bath. Then, Deoxo-fluor (0.560 mL, 3.04 mmol) was added to thesolution. The bottle was capped, and the reaction mixture was stirred at 0 °C for 5-30 min (written ateach substrate in parentheses). The reaction was quenched by addition of aqueous NaHCO3. Themixture was extracted with CH2Cl2 (10.0 mL) three times. The combined organic layer was dried overNa2SO4. Solvents were removed under reduced pressure. The crude material was purified by silica gelcolumn chromatography (hexane/AcOEt = 97:3) to give the corresponding acid fluoride.

65%	With triethylamine trishydrofluoride; N-(difluoro-λ⁴-sulfanylidene)-N-ethylethanaminium tetrafluoroborate In dichloromethane at 25℃; for 2h;
53%	With trichloroisocyanuric acid; caesium fluoride In acetonitrile at 20℃; for 24h; Inert atmosphere; Sealed tube;
99 %Spectr.	With 2,12-di-tert-butyl-7,8-dihydro-6H-dipyrido[1,2-a:2',1'-c][1,4]diazepine-5,9-diium fluoride pentafluorosulfide In N,N-dimethyl-formamide at 90℃; Schlenk technique;
	Multi-step reaction with 2 steps 1: thionyl chloride; N,N-dimethyl-formamide / toluene / 4 h / 75 °C / Sealed tube 2: Palladium⁽⁰⁾ bis(dibenzylideneacetone); (S)-Cl,MeO-BIPHEP / 1,4-dioxane / 1 h / 23 °C / Inert atmosphere; Sealed tube
	Stage #1: biphenyl-4-carboxylic acid In dichloromethane at 0℃; for 0.5h; Schlenk technique; Stage #2: With [bis(2-methoxyethyl)amino]-sulfur trifluoride In dichloromethane at 0℃; for 0.5h; Schlenk technique;	3.2.2. Representative Procedure for the Synthesis of Acyl Fluorides from Carboxylic Acids General procedure: To a 20 mL of Schlenk tube charged with a magnetic stir bar, were successively added carboxylic acid (3.0 mmol) and CH2Cl2 (15 mL). After the mixture was stirred at 0 °C for 30 min, Deoxo-Fluorreagent (608 L, 3.3 mmol, 1.1 equiv) was slowly added to the reaction mixture. After the reaction mixture was stirred at 0 °C for 30 min, the solution was slowly poured into saturated NaHCO3,extracted with CH2Cl2 (3 15 mL), and dried over MgSO4. The crude product was purified by flash chromatography on silica gel to aord the corresponding acyl fluorides 1 [36].
	With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate In tetrahydrofuran at 20℃;
	With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate In tetrahydrofuran at 20℃; Inert atmosphere; Glovebox;
90 %Spectr.	With pyridine; thionyl fluoride In dichloromethane at 20℃; for 0.5h;
	With N-ethyl-N,N-diisopropylamine; fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate In dichloromethane at 23℃; for 0.5h; Sealed tube; Inert atmosphere;

Reference： [1]Gonay, Marie; Batisse, Chloé; Paquin, Jean-François [Journal of Organic Chemistry, 2020, vol. 85, # 15, p. 10253 - 10260]
[2]Song, Hai-Xia; Tian, Ze-Yu; Xiao, Ji-Chang; Zhang, Cheng-Pan [Chemistry - A European Journal, 2020, vol. 26, # 69, p. 16261 - 16265]
[3]Ishida, Naoyoshi; Iwamoto, Hiroaki; Sunagawa, Denise Eimi; Ohashi, Masato; Ogoshi, Sensuke [Synthesis, 2021, vol. 53, # 17, p. 3137 - 3143]
[4]Keaveney, Sinead T.; Schoenebeck, Franziska [Angewandte Chemie - International Edition, 2018, vol. 57, # 15, p. 4073 - 4077][Angew. Chem., 2018, vol. 130, # 15, p. 4137 - 4141,5]
[5]Liang, Yumeng; Zhao, Zhengyu; Taya, Akihito; Shibata, Norio [Organic Letters, 2021, vol. 23, # 3, p. 847 - 852]
[6]Rueping, Magnus; Nikolaienko, Pavlo; Lebedev, Yury; Adams, Alina [Green Chemistry, 2017, vol. 19, # 11, p. 2571 - 2575]
[7]Pan, Fei; Boursalian, Gregory B.; Ritter, Tobias [Angewandte Chemie - International Edition, 2018, vol. 57, # 51, p. 16871 - 16876][Angew. Chem., 2018, vol. 130, p. 17113 - 17118,6]
[8]Wang, Xiu; Wang, Zhenhua; Liu, Li; Asanuma, Yuya; Nishihara, Yasushi [Molecules, 2019, vol. 24, # 9]
[9]Malapit, Christian A.; Bour, James R.; Brigham, Conor E.; Sanford, Melanie S. [Nature, 2018, vol. 563, # 7729, p. 100 - 104]
[10]Malapit, Christian A.; Bour, James R.; Laursen, Simon R.; Sanford, Melanie S. [Journal of the American Chemical Society, 2019, vol. 141, # 43, p. 17322 - 17330]
[11]Lee, Cayo; Sammis, Glenn M.; Thomson, Brodie J. [Chemical Science, 2022, vol. 13, # 1, p. 188 - 194]
[12]Scott, Jason A.; Soto-Velasquez, Monica; Hayes, Michael P.; Lavigne, Justin E.; Miller, Heath R.; Kaur, Jatinder; Ejendal, Karin F. K.; Watts, Val J.; Flaherty, Daniel P. [Journal of Medicinal Chemistry, 2022, vol. 65, # 6, p. 4667 - 4686]

5
[ 1082207-38-2 ]
[ 2714-87-6 ]
[ 73183-34-3 ]
C₃₁H₃₅BO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	With 1,1'-bis-(diphenylphosphino)ferrocene; copper diacetate; sodium trimethylsilanolate In tetrahydrofuran at 0℃; for 3h; regioselective reaction;

Reference： [1]Boreux, Arnaud; Indukuri, Kiran; Gagosz, Fabien; Riant, Olivier [ACS Catalysis, 2017, vol. 7, # 12, p. 8200 - 8204]

6
[ 1082207-38-2 ]
[ 2714-87-6 ]
C₃₂H₂₇F₃O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: copper diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; sodium trimethylsilanolate / tetrahydrofuran / 3 h / 0 °C 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane / 20 h / 60 °C

Reference： [1]Boreux, Arnaud; Indukuri, Kiran; Gagosz, Fabien; Riant, Olivier [ACS Catalysis, 2017, vol. 7, # 12, p. 8200 - 8204]

7
[ 2714-87-6 ]
[ 120120-26-5 ]
[ 398-36-7 ]

Yield	Reaction Conditions	Operation in experiment
40%	With potassium phosphate; [PdCl(cinnamyl)]₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 170℃; for 16h;
37 mg	With potassium phosphate; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 170℃; for 16h; Inert atmosphere; Sealed tube;

Reference： [1]Zhao, Qun; Szostak, Michal [ChemSusChem, 2019, vol. 12, # 13, p. 2983 - 2987]
[2]Keaveney, Sinead T.; Schoenebeck, Franziska [Angewandte Chemie - International Edition, 2018, vol. 57, # 15, p. 4073 - 4077][Angew. Chem., 2018, vol. 130, # 15, p. 4137 - 4141,5]

8
[ 2714-87-6 ]
[ 81290-20-2 ]
[ 398-36-7 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 160℃; for 16h; Sealed tube;

Reference： [1]Keaveney, Sinead T.; Schoenebeck, Franziska [Angewandte Chemie - International Edition, 2018, vol. 57, # 15, p. 4073 - 4077][Angew. Chem., 2018, vol. 130, # 15, p. 4137 - 4141,5]

9
[ 2714-87-6 ]
[ 92-52-4 ]

Yield	Reaction Conditions	Operation in experiment
70%	With triethylsilane; palladium diacetate; tricyclohexylphosphine; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 100℃; for 20h; Inert atmosphere; Sealed tube;

Reference： [1]Ogiwara, Yohei; Sakurai, Yuka; Hattori, Hiroyuki; Sakai, Norio [Organic Letters, 2018, vol. 20, # 14, p. 4204 - 4208]

10
[ 2714-87-6 ]
[ 3218-36-8 ]

Yield	Reaction Conditions	Operation in experiment
84%	With triethylsilane; palladium diacetate; tricyclohexylphosphine In toluene at 100℃; for 20h; Inert atmosphere; Sealed tube;

Reference： [1]Ogiwara, Yohei; Sakurai, Yuka; Hattori, Hiroyuki; Sakai, Norio [Organic Letters, 2018, vol. 20, # 14, p. 4204 - 4208]

11
[bis(difluoromethyl)zinc(dmpu)₂] [ No CAS ]
[ 14002-51-8 ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
28 %Spectr.	With (S)-(-)-5,5'-dichloro-6,6'-dimethoxy-2,2'-bis(diphenylphosphino)-1,1'-biphenyl; bis(dibenzylideneacetone)-palladium⁽⁰⁾ In 1,4-dioxane at 23℃; for 1h; Inert atmosphere; Sealed tube;

Reference： [1]Pan, Fei; Boursalian, Gregory B.; Ritter, Tobias [Angewandte Chemie - International Edition, 2018, vol. 57, # 51, p. 16871 - 16876][Angew. Chem., 2018, vol. 130, p. 17113 - 17118,6]

12
[ 2714-87-6 ]
[ 73183-34-3 ]
[ 144432-80-4 ]

Reference： [1]Chemical Communications,2018,vol. 54,p. 13969 - 13972
[2]Journal of the American Chemical Society,2019,vol. 141,p. 17322 - 17330

13
[ 14002-51-8 ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
75%	With potassium hydrogen difluoride; tetra-n-butyl-ammonium chloride; lithium hydroxide monohydrate In dichloromethane at 20℃; for 16h;	Preparation of Acyl Fluorides 2; General Procedure General procedure: A 250 mL round-bottomed flask was charged with potassium bifluoride(15.62 g, 200 mmol) and water (40.17 g), and stirred at ambienttemperature for 1 h. Then tetrabutylammonium chloride (0.279 g, 1.0mmol, 1 mol%), DCM (used in two-fold volume of acyl chloride) andacyl chloride (1a-y; 100 mmol) were added, and the mixture wasstirred (1400 rpm) with a magnetic bar (fish; 15 × 33 mm) at r.t. forthe time given in the characterization data. The mixture was thentransferred to a separatory funnel, separated, and the aqueous phasewas extracted with DCM (50 mL). The combined organic phases werewashed with brine (50 mL), and dried with MgSO4. The mixture wasfiltered and evaporated, and the residue was distilled under reducedpressure to obtain product 2a-y.
68%	With potassium fluoride; 18-crown-6 ether In tetrahydrofuran at 40℃; for 24h; Schlenk technique; Inert atmosphere;
47%	With potassium fluoride In acetonitrile at 20℃; for 72h; Inert atmosphere;

	With potassium fluoride; 18-crown-6 ether In tetrahydrofuran at 40℃; for 24h; Schlenk technique;	3.2.1. Representative Procedure for the Synthesis of Acyl Fluorides from Acyl Chlorides General procedure: To a 50 mL of Schlenk tube charged with a magnetic stir bar, were successively added acyl chloride(4.0 mmol), 18-crown-6 (52.9 mg, 0.2 mmol, 5 mol %), KF (2.32 g, 40 mmol, 10 equiv), and THF (20 mL).After the reaction was stirred at 40 °C for 24 h, insoluble inorganic solid (KF or KCl) was filtered,and the volatiles were concentrated using a rotary evaporator. The crude product was purified by bulb-to-bulb distillation to aord the corresponding acyl fluorides 1 [35].
	With potassium fluoride; 18-crown-6 ether In tetrahydrofuran at 40℃; for 24h; Schlenk technique; Inert atmosphere;
	With caesium fluoride In acetonitrile at 60℃;
	With potassium fluoride; 18-crown-6 ether In tetrahydrofuran at 40℃; for 24h; Schlenk technique; Inert atmosphere;
	Multi-step reaction with 2 steps 1: triethylamine; 4‐dimethylaminopyridine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate); [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride / 1,2-dichloro-ethane / 18 h / 130 °C / Schlenk technique; Inert atmosphere
	Multi-step reaction with 2 steps 1: triethylamine / N,N-dimethyl acetamide / 0 - 20 °C / Inert atmosphere 2: triethylamine trishydrofluoride / Isopropyl acetate / 2 h / 25 °C / Green chemistry

Reference： [1]Tryniszewski, Michał; Barbasiewicz, Michał [Synthesis, 2022, vol. 54, # 5, p. 1446 - 1460]
[2]Wang, Zhenhua; Wang, Xiu; Nishihara, Yasushi [Chemical Communications, 2018, vol. 54, # 99, p. 13969 - 13972]
[3]Daasbjerg, Kim; Domino, Katrine; Johansen, Martin B.; Skrydstrup, Troels [Organometallics, 2020]
[4]Wang, Xiu; Wang, Zhenhua; Liu, Li; Asanuma, Yuya; Nishihara, Yasushi [Molecules, 2019, vol. 24, # 9]
[5]Wang, Xiu; Wang, Zhenhua; Asanuma, Yuya; Nishihara, Yasushi [Organic Letters, 2019, vol. 21, # 10, p. 3640 - 3643]
[6]Kayumov, Muzaffar; Zhao, Jian-Nan; Mirzaakhmedov, Sharafitdin; Wang, Dong-Yu; Zhang, Ao [Advanced Synthesis and Catalysis, 2020, vol. 362, # 4, p. 776 - 781]
[7]Ishida, Takumi; Nishihara, Yasushi; Wang, Xiu; Wang, Zhenhua [Journal of Organic Chemistry, 2020, vol. 85, # 11, p. 7526 - 7533]
[8]Li, Huan-Le; Lou, Shao-Jie; Mao, Yang-Jie; Pu, Jun; Wu, Feng-Wei; Xu, Dan-Qian; Xu, Zhen-Yuan; Ye, Peng [Organic and Biomolecular Chemistry, 2022, vol. 20, # 20, p. 4091 - 4095]
[9]Aliyu Idris, Muhammad; Song, Kwang Ho; Lee, Sunwoo [Advanced Synthesis and Catalysis, 2022, vol. 364, # 14, p. 2449 - 2453]

14
[ 1006-68-4 ]
[ 2714-87-6 ]
C₂₂H₁₅NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triphenylphosphine; copper(l) chloride In toluene at 80℃; for 24h; Glovebox; Sealed tube;

Reference： [1]Ogiwara, Yohei; Iino, Yurika; Sakai, Norio [Chemistry - A European Journal, 2019, vol. 25, # 26, p. 6513 - 6516]

15
[ 2714-87-6 ]
[ 17955-46-3 ]
[ 51533-89-2 ]

Yield	Reaction Conditions	Operation in experiment
82%	With cesium fluoride; nickel dichloride; In toluene; at 140℃; for 24h;Schlenk technique; Inert atmosphere;	General procedure: A 20 mL dried Schlenk tube containing a stirring bar and CsF (60.8 mg, 0.4 mmol, 2 equiv) was dried with a heat gun under reduced pressure and filled with Ar after cooling to room temperature. To this vessel, were added NiCl2 (1.3 mg, 0.01 mmol, 5 mol %), toluene (1 mL), acyl fluorides (1) (0.2 mmol,1 equiv) and <strong>[17955-46-3]trimethyl(tributylstannyl)silane</strong> (2) (87.2 mg, 0.24 mmol, 1.2 equiv). The mixture was heated at 140 C with stirring for 24 h. The solution was then cooled to room temperature, and the solvent was removed under vacuum. The decarbonylative stannylation products 3 were purified by flash column chromatography on silica gel.

Reference： [1]Molecules,2019,vol. 24

16
[ 2714-87-6 ]
[ 75-24-1 ]
[ 34352-84-6 ]

Yield	Reaction Conditions	Operation in experiment
92%	With bis-diphenylphosphinomethane In toluene at 120℃; for 24h; Schlenk technique; Inert atmosphere;

Reference： [1]Wang, Xiu; Wang, Zhenhua; Asanuma, Yuya; Nishihara, Yasushi [Organic Letters, 2019, vol. 21, # 10, p. 3640 - 3643]

17
[ 2714-87-6 ]
[ 97-93-8 ]
[ 41658-01-9 ]
4-(pentan-3-yl)-1,1'-biphenyl [ No CAS ]
(E)-4-(pent-2-en-3-yl)-1,1'-biphenyl [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
13%	With bis-diphenylphosphinomethane In toluene at 120℃; for 24h; Schlenk technique; Inert atmosphere;

Reference： [1]Wang, Xiu; Wang, Zhenhua; Asanuma, Yuya; Nishihara, Yasushi [Organic Letters, 2019, vol. 21, # 10, p. 3640 - 3643]

18
[ 2714-87-6 ]
[ 5720-07-0 ]
[ 13041-66-2 ]

Yield	Reaction Conditions	Operation in experiment
	With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; diphenyl(methyl)phosphine In tetrahydrofuran at 100℃; for 16h; Inert atmosphere; Glovebox;

Reference： [1]Malapit, Christian A.; Bour, James R.; Brigham, Conor E.; Sanford, Melanie S. [Nature, 2018, vol. 563, # 7729, p. 100 - 104]

19
[ 59409-55-1 ]
[ 2714-87-6 ]
[ 73183-34-3 ]
C₃₀H₃₃BO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With C₃₇H₃₆FeNOPS; copper diacetate; sodium trimethylsilanolate In tetrahydrofuran at 0℃; for 4h; enantioselective reaction;

Reference： [1]Han, Jie; Zhou, Wei; Zhang, Pei-Chao; Wang, Huamin; Zhang, Ronghua; Wu, Hai-Hong; Zhang, Junliang [ACS Catalysis, 2019, vol. 9, # 8, p. 6890 - 6895]

20
[ 745783-97-5 ]
[ 2714-87-6 ]
[ 18057-71-1 ]

Yield	Reaction Conditions	Operation in experiment
81%	With copper (II)-fluoride; potassium fluoride; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; triphenylphosphine In toluene at 150℃; for 24h; Schlenk technique; Inert atmosphere;

Reference： [1]Wang, Xiu; Wang, Zhenhua; Nishihara, Yasushi [Chemical Communications, 2019, vol. 55, # 71, p. 10507 - 10510]

21
[ 2714-87-6 ]
[ 201733-56-4 ]
[ 5123-05-7 ]

Yield	Reaction Conditions	Operation in experiment
40 mg	With C₄₂H₇₁FNiP₂ In tetrahydrofuran at 115℃; for 16h; Inert atmosphere; Sealed tube; chemoselective reaction;

Reference： [1]Malapit, Christian A.; Bour, James R.; Laursen, Simon R.; Sanford, Melanie S. [Journal of the American Chemical Society, 2019, vol. 141, # 43, p. 17322 - 17330]

22
[ 2714-87-6 ]
[ 661-69-8 ]
[ 1625-95-2 ]

Yield	Reaction Conditions	Operation in experiment
77%	With 1,4-bis(dicyclohexylphosphino)butane; palladium dichloride In o-xylene at 140℃; for 10h; Inert atmosphere; Schlenk technique;

Reference： [1]Kayumov, Muzaffar; Zhao, Jian-Nan; Mirzaakhmedov, Sharafitdin; Wang, Dong-Yu; Zhang, Ao [Advanced Synthesis and Catalysis, 2020, vol. 362, # 4, p. 776 - 781]

23
[ 25327-57-5 ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
52%	With benzoyl fluoride; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium⁽⁰⁾ In toluene at 120℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;

Reference： [1]Ogiwara, Yohei; Hosaka, Shintaro; Sakai, Norio [Organometallics, 2020, vol. 39, # 6, p. 856 - 861]

24
[ 2714-87-6 ]
[ 81290-20-2 ]
[ 2369-31-5 ]
2-([1,1’-biphenyl]-4-yl)-1,1,1,3,3,3-hexafluoropropan-2-yl [1,1’-biphenyl]-4-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium fluoride; Trimethyl borate In 1,4-dioxane at 80℃; for 2h; Inert atmosphere; Sealed tube;

Reference： [1]Daasbjerg, Kim; Domino, Katrine; Johansen, Martin B.; Skrydstrup, Troels [Organometallics, 2020]

25
[ 2714-87-6 ]
[ 81290-20-2 ]
[ 2950-30-3 ]
2-([1,1’-biphenyl]-4-yl)-1,1,1,3,3,3-hexafluoropropan-2-yl [1,1’-biphenyl]-4-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium fluoride; Trimethyl borate In 1,4-dioxane at 80℃; for 16h; Inert atmosphere; Sealed tube;

Reference： [1]Daasbjerg, Kim; Domino, Katrine; Johansen, Martin B.; Skrydstrup, Troels [Organometallics, 2020]

26
[ 2714-87-6 ]
[ 91608-15-0 ]
[ 720-75-2 ]

Reference： [1]Journal of Organic Chemistry,2020,vol. 85,p. 7526 - 7533

27
[ 2714-87-6 ]
[ 58521-27-0 ]
[1,1'-biphenyl]-4-yl(pentafluorophenyl)methanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
87%	In 1,4-dioxane at 140℃; for 12h; Schlenk technique; Inert atmosphere; Green chemistry; chemoselective reaction;

Reference： [1]Fu, Liyan; Chen, Qiang; Nishihara, Yasushi [Organic Letters, 2020, vol. 22, # 16, p. 6388 - 6393]

28
[ 498-66-8 ]
[ 2714-87-6 ]
1,2,3,4,4a,9a-hexahydro-7-phenyl-1,4-methanofluoren-9-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	With potassium fluoride; palladium diacetate; tricyclohexylphosphine In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 24h; Inert atmosphere; Sealed tube;

Reference： [1]Sakurai, Yuka; Ogiwara, Yohei; Sakai, Norio [Chemistry - A European Journal, 2020, vol. 26, # 57, p. 12972 - 12977]

29
[ 2714-87-6 ]
[ 2170-06-1 ]
[ 15784-39-1 ]

Yield	Reaction Conditions	Operation in experiment
80%	With copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; palladium dichloride In N,N-dimethyl-formamide; toluene at 150℃; for 24h; Schlenk technique; Inert atmosphere;

Reference： [1]Chen, Qiang; Fu, Liyan; Nishihara, Yasushi [Chemical Communications, 2020, vol. 56, # 57, p. 7977 - 7980]

30
[ 2714-87-6 ]
[ 89343-06-6 ]
([1,1'-biphenyl]-4-ylethynyl)triisopropylsilane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; tributyl-amine; 1,3-bis-(diphenylphosphino)propane In 1,4-dioxane at 140℃; for 24h; Inert atmosphere; Schlenk technique;	Silylated Internal Alkynes 3: General Procedure General procedure: An oven-dried 20 mL Schlenk tube containing a magnetic stirring bar was charged with Ni(cod)2 (5.5 mg, 0.02 mmol, 10mol%), DPPP (12.4 mg, 0.03 mmol, 15 mol%), 1,4-dioxane (1 mL)under dry N2, and the mixture was stirred for 30 s at r.t. The appropriate acyl fluoride 1 (0.2 mmol), silyl alkyne 2 (0.4mmol), and Bu3N (0.3 mmol) were added, and the mixture washeated at 140 °C in a heating block with stirring for 24 h, thencooled to r.t. The reaction was quenched with sat. aq NH4Cl, andthe mixture was extracted with Et2O. The combined organicphase was dried (MgSO4) and concentrated under vacuum, andthe residue was purified by column chromatography (silica gel,EtOAc-hexane).

Reference： [1]Chen, Qiang; Fu, Liyan; You, Jingwen; Nishihara, Yasushi [Synlett, 2021, vol. 32, # 15, p. 1560 - 1564]

31
C₃₀H₁₈F₁₀O [ No CAS ]
[ 2714-87-6 ]
1-([1,1′-biphenyl]-4-yl)-2,2,3,3,3-pentafluoropropan-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 76 %Spectr. 2: 14 %Spectr.	With cesium fluoride In benzene-d6; N,N-dimethyl-formamide at 140℃; for 4h; Inert atmosphere;	1-8. Investigation of reactivity of ester 3b under CsF catalytic system. 3b (30.0 mg, 0.0500 mmol) and ,,-trifluorotoluene (5.0 L, 0.041 mmol) were dissolved to a mix solvent of DMF and C6D6 (0.500 mL, v/v' = 4/1). After addition of CsF (1.55 mg, 0.0102 mmol) to a pressure-tight NMR tube (Wilmad-LabGlass, 524-PV-7; total volume: 2 mL), the solution was transferred to the tube. The reaction tube was heated at 140 °C for 4 h. The yields of the ketone 2b and acyl fluoride 1b were determined by 19F NMR measurement of the crude material using an internal standard.

Reference： [1]Ishida, Naoyoshi; Iwamoto, Hiroaki; Sunagawa, Denise Eimi; Ohashi, Masato; Ogoshi, Sensuke [Synthesis, 2021, vol. 53, # 17, p. 3137 - 3143]

32
[ 116-14-3 ]
[ 2714-87-6 ]
1-([1,1′-biphenyl]-4-yl)-2,2,3,3,3-pentafluoropropan-1-one [ No CAS ]
C₃₀H₁₈F₁₀O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 38% 2: 13 %Spectr.	With cesium fluoride In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;	1-6. Stoichiometric reaction at 80 C and Isolation of ester 3b. Biphenyl-4-carboxylic acid fluoride (100 mg, 0.499 mmol) was dissolved into DMF (2.50 mL) as asolvent. After addition of CsF (76.0 mg, 0.500 mmol) to a pressure-tight reaction vessel (total volumeis 12 mL) as a reactor, the resulting solution was transferred to the tube. Then, TFE (2.5 atm) wascharged into the reactor. The reaction mixture was heated at 80 °C for 2 h. After, the remaining TFE was purged from the reactor, the reaction mixture was quenched by addition of water (10.0 mL). The resulting mixture was extracted with ether (10 mL) three times. The solvents were removed under reduced pressure. The yields of the ketone 2b and ester 3b were estimated by 19F NMR measurement of the crude material (2b: 13%, 3b: 47%). The crude material was purified by preparative HPLC to give the corresponding ester 3b as colorless oil in 38% yield (56.7 mg, 0.0944 mmol).

Reference： [1]Ishida, Naoyoshi; Iwamoto, Hiroaki; Sunagawa, Denise Eimi; Ohashi, Masato; Ogoshi, Sensuke [Synthesis, 2021, vol. 53, # 17, p. 3137 - 3143]

33
[ 116-14-3 ]
[ 2714-87-6 ]
1-([1,1′-biphenyl]-4-yl)-2,2,3,3,3-pentafluoropropan-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With cesium fluoride In N,N-dimethyl-formamide at 140℃; for 4h; Inert atmosphere;	CsF-Catalyzed Fluoroacylation of TFE with Acyl Fluorides 1; GeneralProcedure General procedure: Under N2 atmosphere, acyl fluoride 1 (0.500 mmol) was dissolved in DMF (2.50 mL) as a solvent. After addition of CsF (3.8 mg, 0.025mmol) to a pressure-tight tube as a reactor (Wilmad-LabGlass, 513-7PVM-9; 12 mL total volume), the solution was transferred to the tube. TFE (1.5 atm, > ca. 1.1 equiv) was then charged into the reactor and the reaction mixture was heated at 140 °C for 4 h. After remaining TFE was purged from the reactor, the reaction was quenched with water (10 mL) and the resulting mixture was extracted with Et2O (3 ×10 mL). The combined organic phase was dried over Na2SO4, the solvents were removed under reduced pressure, and the crude material was purified by silica gel column chromatography (hexane/EtOAc =97:3) to give the pentafluoroethyl ketone 2. For compounds 2a, 2e,2h, and 2l-o, we present only NMR data in this section.

Reference： [1]Ishida, Naoyoshi; Iwamoto, Hiroaki; Sunagawa, Denise Eimi; Ohashi, Masato; Ogoshi, Sensuke [Synthesis, 2021, vol. 53, # 17, p. 3137 - 3143]

34
[ 7677-24-9 ]
[ 2714-87-6 ]
[ 2920-38-9 ]

Yield	Reaction Conditions	Operation in experiment
98%	With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium iodide In toluene at 180℃; for 24h; Glovebox; Inert atmosphere; Sealed tube;	Method A: Palladium-catalyzed Cyanation of Acyl Fluorides by Trimethylsilyl Cyanide (3a,Table 2) General procedure: In a glovebox filled with nitrogen, Pd2(dba)3*CHCl3 (23.8 mg, 0.023 mmol), Xantphos (34.1 mg,0.059 mmol), NaI (101.9 mg, 0.68 mmol), 1a (55.8 mg, 0.45 mmol) and 2 (67.5 mg, 0.68 mmol)were added to a 10 mL-sample vial with a Teflon-sealed screwcap. Toluene (1.5 mL) was then added,and the vial was then sealed with the cap. The vial was stirred at 180 °C for 24 h. After allowing thereaction mixture to cool to room temperature, diisopropylamine was added to the crude mixture andfiltered through a pad of silica gel and the pad was wahsed with EtOAc. The filtrate was analyzed by GC using dodecane as an internal standard.

Reference： [1]Sakurai, Shun; Tobisu, Mamoru [Chemistry Letters, 2021, vol. 50, # 1]

35
4-iodobenzoyl fluoride [ No CAS ]
[ 98-80-6 ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
63%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate In tetrahydrofuran at 40℃; for 24h;	According to the literature protocol,2 1p was prepared by the reaction using Pd(PPh3)4 (116 mg, 0.1mmol), CuTC (210 mg, 1.1 mmol), phenylboronic acid (244 mg, 2 mmol), and 1o (250 mg, 1.0mmol) in THF (5 mL) at 40 °C for 24 h. After allowing the reaction mixture to cool to roomtemperature, the yield was estimated by 19F NMR (internal standard: fluorobenzene, 1p: 93%, 1o:7%).The product was isolated by silica gel column chromatography.

Reference： [1]Sakurai, Shun; Tobisu, Mamoru [Chemistry Letters, 2021, vol. 50, # 1]

36
[ 2714-87-6 ]
[ 398-36-7 ]

Yield	Reaction Conditions	Operation in experiment
91%	With 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride; pyridine hydrofluoride In neat (no solvent) at 70℃; for 24h; Sealed tube;

Reference： [1]Liang, Yumeng; Taya, Akihito; Zhao, Zhengyu; Saito, Norimichi; Shibata, Norio [Beilstein Journal of Organic Chemistry, 2020, vol. 16, p. 3052 - 3058]

37
[ 3218-36-8 ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
83%	With trichloroisocyanuric acid; cesium fluoride In acetonitrile at 20℃; for 24h; Inert atmosphere; Sealed tube;

Reference： [1]Liang, Yumeng; Zhao, Zhengyu; Taya, Akihito; Shibata, Norio [Organic Letters, 2021, vol. 23, # 3, p. 847 - 852]

38
[ 3597-91-9 ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
64%	With trichloroisocyanuric acid; cesium fluoride In acetonitrile at 20℃; for 24h; Inert atmosphere; Sealed tube;

Reference： [1]Liang, Yumeng; Zhao, Zhengyu; Taya, Akihito; Shibata, Norio [Organic Letters, 2021, vol. 23, # 3, p. 847 - 852]

39
[ 2714-87-6 ]
[ 106-45-6 ]
[ 1361950-30-2 ]

Yield	Reaction Conditions	Operation in experiment
90%	With (1,2-dimethoxyethane)dichloronickel(II); 1,3-bis-(diphenylphosphino)propane; sodium carbonate In toluene at 140℃; for 24h; Inert atmosphere; Schlenk technique;	Thioethers 3; General Procedure General procedure: An oven-dried 20 mL of Schlenk tube containing a magnetic stirringbar was charged with NiCl2·DME (4.39 mg, 0.02 mmol, 10 mol%),DPPP (24.8 mg, 0.06 mmol, 30 mol%), and toluene (1 mL) under N2,which was stirred for 30 seconds at rt. Then, acyl fluoride 1 (0.2mmol), 4-methylthiophenol (2; 37 mg, 0.3 mmol), and Na2CO3 (31.8mg, 0.3 mmol) were added. The mixture was heated at 140 °C in aheating block with stirring for 24 h. After cooling to rt, the mixturewas quenched with sat. aq NH4Cl and the aqueous solution was extractedwith Et2O. The combined organic phases were dried (anhydMgSO4), and evaporated under vacuum to remove the volatiles. Theresidue was purified by column chromatography (EtOAc/hexane) onsilica gel to afford the corresponding product 3.

Reference： [1]You, Jingwen; Chen, Qiang; Nishihara, Yasushi [Synthesis, 2021, vol. 53, # 17, p. 3045 - 3050]

40
S-(trifluoromethyl)(S)-2-(6-methoxynaphthalen-2-yl)propanethioate [ No CAS ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
65.5%	With potassium fluoride; 18-crown-6 ether In dimethyl sulfoxide at 35℃; for 24h;	3 The synthesis steps and process are: add potassium fluoride (1.8mmol, 104.4mg) into a 10mL reaction tube equipped with a magnetic stirrer,18-crown ether-6 (1.8mmol, 475.2mg),Trifluoromethyl p-phenylbenzoate (1.0mmol, 282mg),Then add 4.0mL dimethyl sulfoxide, fix the reaction tube on the magnetic stirrer,The reaction was carried out in an oil bath at 35 degrees Celsius for 24 hours, and the target product acyl fluoride 1c was obtained by separation and purification with a yield of 65.5%.

Reference： [1]Current Patent Assignee: SHANDONG LINGHAI BIO TECH - CN113233974, 2021, A Location in patent: Paragraph 0036-0039

41
[ 2714-87-6 ]
[ 79141-00-7 ]
N-tert-butyl-N-isopropyl-4-phenylbenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With chloro-trimethyl-silane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;	Preparation of Amides 3; General Procedure General procedure: Reactions of lithium amide with acyl fluoride. A 30 mL Schlenk flaskwas charged with acyl fluoride (2.0 mmol) and flushed with argon.Then, THF (4 mL) was added, the mixture was placed in a cooling bathat -78 °C, and TMSCl (0.38 mL, 3.0 mmol) was added. To the resultingmixture a preformed solution of lithium amide in THF (see procedureabove) was added over ca. 1 min. After 30 min, the cooling bath wasremoved, the mixture was immediately quenched with saturatedaqueous NaHCO3 (20 mL), and then extracted with EtOAc (3 × 25 mL).The combined organic phases were washed with brine (25 mL), driedwith MgSO4, filtered off and evaporated. The product was purified bycolumn chromatography (cyclohexane/EtOAc v/v 20:1→10:1). Preliminaryexperiments (Scheme 3) were carried out according to theGeneral Procedure. Products of reaction with LiHMDS were isolated asN-unsubstituted amides.

Reference： [1]Tryniszewski, Michał; Barbasiewicz, Michał [Synthesis, 2022, vol. 54, # 5, p. 1446 - 1460]

42
4-(difluoro((trifluoromethyl)sulfonyl)methyl)-1,1'-biphenyl [ No CAS ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
	With silica gel In dichloromethane at 40℃; for 0.0833333h;

Reference： [1]Yang, Ren-Yin; Gao, Xinyan; Gong, Kehao; Wang, Juan; Zeng, Xiaojun; Wang, Mingwei; Han, Junbin; Xu, Bo [Organic Letters, 2022, vol. 24, # 1, p. 164 - 168]

43
[ 2714-87-6 ]
[ 501-65-5 ]
[ 185990-03-8 ]
(Z)-(2-([1,1'-biphenyl]-4-yl)-1,2-diphenylethenyl)dimethyl(phenyl)silane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	With potassium fluoride; [1,3-bis(2,6-di-iso-propylphenyl)imidazol-2-ylidene]copper(I) triflate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 140℃; for 24h; Inert atmosphere; Schlenk technique;

Reference： [1]Chen, Qiang; Li, Zhenyao; Nishihara, Yasushi [Organic Letters, 2022, vol. 24, # 1, p. 385 - 389]

44
[ 2714-87-6 ]
2-(5-amino-3-methyl-1H-pyrazol-1-yl)-6-ethylpyrimidin-4(1H)-one [ No CAS ]
N-(1-(6-ethyl-4-oxo-3,4-dihydropyrimidin-2-yl)-3-methyl-1H-pyrazol-5-yl)-[1,1′-biphenyl]-4-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.045 g	Stage #1: 2-(5-amino-3-methyl-1H-pyrazol-1-yl)-6-ethylpyrimidin-4(1H)-one With lithium hexamethyldisilazane In tetrahydrofuran at 23℃; for 0.5h; Stage #2: [1,1'-biphenyl]-4-carbonyl fluoride In tetrahydrofuran; dichloromethane Heating;

Reference： [1]Scott, Jason A.; Soto-Velasquez, Monica; Hayes, Michael P.; Lavigne, Justin E.; Miller, Heath R.; Kaur, Jatinder; Ejendal, Karin F. K.; Watts, Val J.; Flaherty, Daniel P. [Journal of Medicinal Chemistry, 2022, vol. 65, # 6, p. 4667 - 4686]

45
[ 188290-36-0 ]
[ 2714-87-6 ]
[ 34715-95-2 ]

Yield	Reaction Conditions	Operation in experiment
63%	With trimethylsilyl trifluoropmethanesulfonate In 1,2-dichloro-ethane for 4h; Inert atmosphere;

Reference： [1]Li, Huan-Le; Lou, Shao-Jie; Mao, Yang-Jie; Pu, Jun; Wu, Feng-Wei; Xu, Dan-Qian; Xu, Zhen-Yuan; Ye, Peng [Organic and Biomolecular Chemistry, 2022, vol. 20, # 20, p. 4091 - 4095]

46
[ 2714-87-6 ]
(R)-alanine tert-butyl ester [ No CAS ]
C₂₀H₂₃NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane for 5h; Inert atmosphere;

Reference： [1]Li, Huan-Le; Lou, Shao-Jie; Mao, Yang-Jie; Pu, Jun; Wu, Feng-Wei; Xu, Dan-Qian; Xu, Zhen-Yuan; Ye, Peng [Organic and Biomolecular Chemistry, 2022, vol. 20, # 20, p. 4091 - 4095]

47
1-([1,1'-biphenyl]-4-carbonyl)piperidine-2,6-dione [ No CAS ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
87%	With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) In 1,2-dichloro-ethane at 130℃; for 18h; Schlenk technique; Inert atmosphere;

Reference： [1]Li, Huan-Le; Lou, Shao-Jie; Mao, Yang-Jie; Pu, Jun; Wu, Feng-Wei; Xu, Dan-Qian; Xu, Zhen-Yuan; Ye, Peng [Organic and Biomolecular Chemistry, 2022, vol. 20, # 20, p. 4091 - 4095]

48
[ 2714-87-6 ]
[ 3597-91-9 ]

Yield	Reaction Conditions	Operation in experiment
133 mg	With sodium tetrahydridoborate In dichloromethane; N,N-dimethyl acetamide at 20℃; for 1h;

Reference： [1]Bolduc, Trevor G.; Lee, Cayo; Chappell, William P.; Sammis, Glenn M. [Journal of Organic Chemistry, 2022, vol. 87, # 11, p. 7308 - 7318]

49
2-([1,1'-biphenyl]-4-carbonyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide [ No CAS ]
[ 2714-87-6 ]

Yield	Reaction Conditions	Operation in experiment
82%	With triethylamine trishydrofluoride In Isopropyl acetate at 25℃; for 2h; Green chemistry;

Reference： [1]Aliyu Idris, Muhammad; Song, Kwang Ho; Lee, Sunwoo [Advanced Synthesis and Catalysis, 2022, vol. 364, # 14, p. 2449 - 2453]

50
[ 2714-87-6 ]
C₅₀H₇₄F₂O₃P₂Pd [ No CAS ]
[ 1583-56-8 ]

Yield	Reaction Conditions	Operation in experiment
	With tricyclohexylphosphine In hexadeuterobenzene at 80℃; Inert atmosphere; Glovebox;

Reference： [1]Hattori, Hiroyuki; Ogiwara, Yohei; Sakai, Norio [Organometallics, 2022, vol. 41, # 12, p. 1509 - 1518]

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P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 2714-87-6 ] {[proInfo.proName]}

Quality Control of [ 2714-87-6 ]

Related Doc. of [ 2714-87-6 ]

Product Details of [ 2714-87-6 ]

Safety of [ 2714-87-6 ]

Application In Synthesis of [ 2714-87-6 ]

[ 2714-87-6 ] Synthesis Path-Downstream 1~50

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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