[ CAS No. 2732-80-1 ] {[proInfo.proName]}

Name: 2732-80-1|2-Bromo-1-chloro-4-methoxybenzene|97%
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SKU: A306991
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Quality Control of [ 2732-80-1 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 2732-80-1 ]

Product Details of [ 2732-80-1 ]

CAS No. :	2732-80-1	MDL No. :	MFCD00070739
Formula :	C₇H₆BrClO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	SQHMXVXKKCXIGN-UHFFFAOYSA-N
M.W :	221.48	Pubchem ID :	24212081
Synonyms :

Calculated chemistry of [ 2732-80-1 ]

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.14
Num. rotatable bonds :	1
Num. H-bond acceptors :	1.0
Num. H-bond donors :	0.0
Molar Refractivity :	45.64
TPSA :	9.23 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.41 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.45
Log Po/w (XLOGP3) :	3.16
Log Po/w (WLOGP) :	3.11
Log Po/w (MLOGP) :	3.15
Log Po/w (SILICOS-IT) :	3.14
Consensus Log Po/w :	3.0

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.58
Solubility :	0.058 mg/ml ; 0.000262 mol/l
Class :	Soluble
Log S (Ali) :	-3.02
Solubility :	0.209 mg/ml ; 0.000946 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.0
Solubility :	0.0221 mg/ml ; 0.0001 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.62

Safety of [ 2732-80-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 2732-80-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 2732-80-1 ]
Downstream synthetic route of [ 2732-80-1 ]

[ 2732-80-1 ] Synthesis Path-Upstream 1~6

1
[ 2732-80-1 ]
[ 13659-24-0 ]

Reference： [1] Patent: WO2009/62990, 2009, A2, . Location in patent: Page/Page column 40

2
[ 2401-24-3 ]
[ 2732-80-1 ]

Reference： [1] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000
[2] Journal of the American Chemical Society, 1955, vol. 77, p. 543,546

3
[ 10298-80-3 ]
[ 2732-80-1 ]

Reference： [1] Journal of the American Chemical Society, 1955, vol. 77, p. 543,546
[2] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000

4
[ 96-96-8 ]
[ 2732-80-1 ]

Reference： [1] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000

5
[ 50586-69-1 ]
[ 2732-80-1 ]

Reference： [1] Journal of Organic Chemistry, 1947, vol. 12, p. 213,215

6
[ 13659-24-0 ]
[ 77-78-1 ]
[ 2732-80-1 ]

Reference： [1] Journal of Organic Chemistry, 1947, vol. 12, p. 213,215

[ 2732-80-1 ] Synthesis Path-Downstream 1~88

1
[ 2401-24-3 ]
[ 2732-80-1 ]

Reference： [1]Chemistry - A European Journal,2017,vol. 23,p. 9996 - 10000
[2]Journal of the American Chemical Society,1955,vol. 77,p. 543,546

2
[ 13659-24-0 ]
[ 77-78-1 ]
[ 2732-80-1 ]

Reference： [1]Journal of Organic Chemistry,1947,vol. 12,p. 213,215

3
[ 2732-80-1 ]
[ 21450-64-6 ]
2-chloro-5-methoxy-2',6'-dimethyl-biphenyl [ No CAS ]
2-methoxy-5-methylfluorene [ No CAS ]
3-methoxy-5-methylfluorene [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 5057 - 5060
[2]Tetrahedron,2008,vol. 64,p. 2537 - 2552

4
[ 50586-69-1 ]
[ 2732-80-1 ]

Reference： [1]Journal of Organic Chemistry,1947,vol. 12,p. 213,215

5
[ 10298-80-3 ]
[ 2732-80-1 ]

Reference： [1]Journal of the American Chemical Society,1955,vol. 77,p. 543,546
[2]Chemistry - A European Journal,2017,vol. 23,p. 9996 - 10000

6
[ 910907-13-0 ]
[ 2732-80-1 ]
C₂₃H₂₆ClN₅O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; for 4h;Heating / reflux;	Example 102. 3-(2-(3-(2-(PyrroIidin-l-yl)ethoxy)phenylainino)pyrimidin-5- ylaminoV4-chIorophenol (XLV); [0276] To a solution of compound 56 described in Example 98 (100 mg, 0.33 mmol) in anhydrous 1,4-dioxane (30 mL) was added 2-bromo-l-chloro-4-methoxybenzene (82 mg, 0.36 mmol), Cs2CO3 (436 mg, 1.33 mmol), Pd2(dba) 3 (31 mg, 0.03 mmol), and Xantphos (58 mg, 0.10 mmol). The suspension was heated under reflux for 4 h under Ar. The solid was filtered off and washed with EtOAc. The filtrate was washed with brine (1 x 100 mL) and the aqueous was extracted with EtOAc (3 x 50 mL). Combined organic solution was dried (Na2SO4) and concentrated until 10 ml remain solution before adding hexane (100 mL). The mixture was sonicated for 2 min. The solid was collected by filtration and washed with hexane. The solvent was removed in vacuo and the crude material was further purified by flash column (SiO2/CH2Cl2, then CH2Cl2 : MeOH : NH3-H2O = 100 : 10 : 1). The obtained yellow solid was dissolved in anhydrous CH2Cl2 (10 mL). The 1.0 M BBr3 in CH2Cl2 (1.0 mL, 1.0 mmol) was added. The reaction mixture was stirred for 4 h at room temperature. The saturated NaHCO3 (20 ml) was added and sonicated. The organic layer was separated and aqueous was extracted with CH2Cl2 (3 x 20 mL). The combined organic solution was dried (Na2SO4). The solvent was removed in vacuo. The crude product was purified by using HPLC. The HPLC fractions containing product were combined and neutralized with saturated NaHCO3 (50 mL). The free base was extracted with EtOAc (2 x 50 mL). The combined organic layer EPO <DP n="97"/>was dried (Na2SO4). The solvent was removed in vacuo. The free base was dissolved in MeOH (2 mL) and the 2.0 M solution of HCl (0.2 mL, 0.4 rnmol) in Et2O was added. The solution was stirred for 5 min at room temperature before removing solvent. The residue was dissolved in MeOH (1 mL) and anhydrous Et2O (20 mL) was added. The solid was collected by centrifuging and the HCl salt of the title compound (28 mg, 18%) was afforded as a yellow solid.[0277] 1H NMR (500 MHz, DMSO-d6): delta 1.88-191 (m, 2H), 1.99-2.04 (m, 2H), 3.08- 3.13 (m, 2H), 3.54-3.58 (m, 4H), 4.31 (t, J= 4.8 Hz, 2H), 6.20 (dd, J= 8.5 Hz, J= 2.6 Hz, IH), 6.26 (d, J= 2.8 Hz, 2H), 6.59 (dd, J= 7.9 Hz, J= 2.4 Hz, IH), 7.13 (d, J= 8.6 Hz, IH), 7.21 (t, J= 8.2 Hz, IH), 7.34 (m, 2H), 7.57 (t, J= 2.2 Hz, IH), 8.38 (s, 2H), 9.65 (s, IH). MS (ES+): m/z = 426 (M+H)+.

Reference： [1]Patent: WO2006/101977,2006,A2 .Location in patent: Page/Page column 95-96

7
[ 371-41-5 ]
[ 2732-80-1 ]
[ 939771-49-0 ]

Yield	Reaction Conditions	Operation in experiment
49%	With 1-Methylpyrrolidine; copper(l) iodide; caesium carbonate; at 200℃; for 0.5h;Microwave irradiation;	4-Chloro-3-(4-fluorophenoxy)phenol; 2-Bromo-1-chloro-4-methoxybenzene (200 mg, 0.9 mmol), cesium carbonate (588 mg, 1.8 mmol), 4-fluorophenol (202 mg, 1.8 mmol), CuI (17 mg, 0.09 mmol) and N-methylpyrrolidine (1 mL) were sealed in a microwave vessel and heated in a microwave at 200 C. for 1800 s. The crude reaction mixture was purified by chromatography on silica gel. Elution with 10:90 ethyl acetate:heptane with a gradient to 30:70 ethyl acetate:heptane afforded 1-chloro-2-(4-fluorophenoxy)-4-methoxybenzene (112 mg, 0.44 mmol, 49%). 1-Chloro-2-(4-fluorophenoxy)-4-methoxybenzene (110 mg, 0.44 mmol) prepared above, was dissolved in DCM (5.00 mL) and stirred under argon at -78 C. Boron tribromide (1.0M in DCM, 2.20 mL) was then added and the reaction stirred at -78 C. for 1 h. The reaction was allowed to warm to ambient temperature overnight, quenched with saturated Na2CO3 (aq) and then the aqueous and organic layers were separated. The solvent was removed in vacuo and the crude product was purified by chromatography on silica gel. Elution with 2:98 ethyl acetate:heptane with a gradient to 20:80 ethyl acetate:heptane afforded 4-chloro-3-(4-fluorophenoxy)phenol (92 mg, 0.38 mmol, 87%). M.S. (ESI) (m/z): 237, 239 [M-H]-
49%	With 1-Methylpyrrolidine; caesium carbonate;copper(l) iodide; at 200℃; for 0.5h;Microwave;	2-Bromo-1-chloro-4-methoxybenzene (200mg, 0.9mmol), cesium carbonate (588mg, 1.8mmol), 4-fluorophenol (202mg, 1.8mmol), CuI (17mg, 0.09mmol) and N- methylpyrrolidine (1 mL) were sealed in a microwave vessel and heated in a microwave at 2000C for 1800s. The crude reaction mixture was purified by chromatography on silica gel. Elution with 10:90 ethyl acetate:heptane with a gradient to 30:70 ethyl acetate:heptane afforded 1-chloro-2-(4-fluorophenoxy)-4-methoxybenzene (112mg, 0.44mmol, 49%). 1-Chloro-2-(4-fluorophenoxy)-4-methoxybenzene (110mg, 0.44mmol) prepared above, was dissolved in DCM (5.0OmL) and stirred under argon at -780C. Boron tribromide (1.0M in DCM, 2.2OmL) was then added and the reaction stirred at -780C for 1 h. The reaction was allowed to warm to ambient temperature overnight, quenched with saturated Na2CO3 (aq) and then the aqueous and organic layers were separated. The solvent was removed in vacuo and the crude product was purified by chromatography on silica gel. Elution with <n="20"/>2:98 ethyl acetate:heptane with a gradient to 20:80 ethyl acetate:heptane afforded 4- chloro-3-(4-fluorophenoxy)phenol (92mg, 0.38mmol, 87%). M.S. (ESI) (m/z): 237, 239 [M- H]-

Reference： [1]Patent: US2007/185156,2007,A1 .Location in patent: Page/Page column 8
[2]Patent: WO2007/63071,2007,A1 .Location in patent: Page/Page column 18-19

8
[ 2732-80-1 ]
[ 939771-48-9 ]

Yield	Reaction Conditions	Operation in experiment
87%		4-Chloro-3-(4-fluorophenoxy)phenol; 2-Bromo-1-chloro-4-methoxybenzene (200 mg, 0.9 mmol), cesium carbonate (588 mg, 1.8 mmol), 4-fluorophenol (202 mg, 1.8 mmol), CuI (17 mg, 0.09 mmol) and N-methylpyrrolidine (1 mL) were sealed in a microwave vessel and heated in a microwave at 200 C. for 1800 s. The crude reaction mixture was purified by chromatography on silica gel. Elution with 10:90 ethyl acetate:heptane with a gradient to 30:70 ethyl acetate:heptane afforded 1-chloro-2-(4-fluorophenoxy)-4-methoxybenzene (112 mg, 0.44 mmol, 49%). 1-Chloro-2-(4-fluorophenoxy)-4-methoxybenzene (110 mg, 0.44 mmol) prepared above, was dissolved in DCM (5.00 mL) and stirred under argon at -78 C. Boron tribromide (1.0M in DCM, 2.20 mL) was then added and the reaction stirred at -78 C. for 1 h. The reaction was allowed to warm to ambient temperature overnight, quenched with saturated Na2CO3 (aq) and then the aqueous and organic layers were separated. The solvent was removed in vacuo and the crude product was purified by chromatography on silica gel. Elution with 2:98 ethyl acetate:heptane with a gradient to 20:80 ethyl acetate:heptane afforded 4-chloro-3-(4-fluorophenoxy)phenol (92 mg, 0.38 mmol, 87%). M.S. (ESI) (m/z): 237, 239 [M-H]-

Reference： [1]Patent: US2007/185156,2007,A1 .Location in patent: Page/Page column 8

9
[ 2732-80-1 ]
[ 13659-24-0 ]

Yield	Reaction Conditions	Operation in experiment
	With boron tribromide; In dichloromethane; at -20 - 20℃; for 1.58333h;	BBr3 (50 ml) was added slowly in drops over 15 minutes to a solution of 2-bromo-l- chloro-4-methoxybenzene (0.448 mol) in CH2Cl2 (600 ml), stirred at -2O0C. The resultant reaction mixture was stirred for 20 minutes at -200C, then it was warmed to room temperature and stirred for one hour at room temperature, yielding 85 g of intermediate (75).

Reference： [1]Patent: WO2009/62990,2009,A2 .Location in patent: Page/Page column 40

10
[ 2732-80-1 ]
[ 316122-26-6 ]
[ 1131890-63-5 ]

Reference： [1]Journal of the American Chemical Society,2009,vol. 131,p. 4031 - 4041

11
[ 24544-04-5 ]
[ 2732-80-1 ]
[ 1227188-08-0 ]

Reference： [1]Tetrahedron Letters,2010,vol. 51,p. 2241 - 2243

12
[ 1749-19-5 ]
[ 2732-80-1 ]
[ 1259658-97-3 ]

Reference： [1]Chemistry - A European Journal,2010,vol. 16,p. 11707 - 11711

13
[ 124-38-9 ]
[ 2732-80-1 ]
[ 6280-89-3 ]

Yield	Reaction Conditions	Operation in experiment
52%		Example 53. 2-Chloro-5-methoxybenzoic acid (39); [0195] A solution of 2-chloro-5-methoxy-bromobenzene (5 g, 22.6 mmol) in THF (55 niL) was cooled to -78 0C and 2.5 M nBuLi in hexanes (10.8 mL) was added dropwise over 15 min keeping the temperature of the reaction below -60 0C. When the reaction had cooled fully back to -78C, 13 pieces of solid CO2 (2-4 cm by lcm cylinders) were rubbed free of ice and added slowly to the reaction. The cold bath was removed and the reaction allowed to slowly warm to room temperature (ca. 1.5 hours). The reaction was diluted with 85 mL EtOAc and 100 mL NaHCO3 (sat.). The pH was adjusted to 10-12 with 30% NaOH. The layers were separated and the aqueous layer was acidified with HCl (cone.) to precipitate the title compound as an off-white solid which was collected by filtration and rinsed with cold water. Traces of solvents were removed in vacuo (2.2 g, 52 %).[0196] 1H NMR (DMSO-d6) delta 3.33 (s, 3H), 7.10 (dd, J= 8.9, 3.3 Hz, IH), 7.28 (d, J= 3.2 Hz, IH), 7.43 (d, J= 8.9 Hz, IH). MS (ES+): m/z = 169 (MH-H)+. LC retention time: 2.20 min.

Reference： [1]Patent: WO2006/101977,2006,A2 .Location in patent: Page/Page column 64-65

14
[ 1284229-90-8 ]
[ 2732-80-1 ]
[ 1284229-85-1 ]

Reference： [1]Angewandte Chemie - International Edition,2011,vol. 50,p. 2350 - 2353

15
[ 1284230-13-2 ]
[ 2732-80-1 ]
[ 1284230-22-3 ]

Reference： [1]Angewandte Chemie - International Edition,2011,vol. 50,p. 2350 - 2353

16
[ 2732-80-1 ]
[ 56984-35-1 ]
[ 1333434-90-4 ]

Reference： [1]Angewandte Chemie - International Edition,2011,vol. 50,p. 7290 - 7294

17
[ 117-99-7 ]
[ 2732-80-1 ]
[ 1331753-60-6 ]

Reference： [1]Journal of the American Chemical Society,2011,vol. 133,p. 14228 - 14231

18
[ 117-99-7 ]
[ 2732-80-1 ]
[ 1331753-37-7 ]

Reference： [1]Journal of the American Chemical Society,2011,vol. 133,p. 14228 - 14231

19
[ 688-74-4 ]
[ 2732-80-1 ]
[ 7439-95-4 ]
B(OC₄H₉)2(C₆H₃(Cl)(OCH₃))2^(1-)*MgBr⁽¹⁺⁾=B(OC₄H₉)2(C₆H₃(Cl)(OCH₃))2MgBr [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2011,vol. 50,p. 7290 - 7294

20
[ 2732-80-1 ]
[ 52379-48-3 ]
[ 1350629-01-4 ]

Reference： [1]Organic Letters,2011,vol. 13,p. 6516 - 6519

21
[ 2732-80-1 ]
[ 1527-91-9 ]
[ 1350629-08-1 ]

Reference： [1]Organic Letters,2011,vol. 13,p. 6516 - 6519

22
[ 2732-80-1 ]
[ 1993-03-9 ]
[ 1354787-31-7 ]

Yield	Reaction Conditions	Operation in experiment
88%	With caesium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 80℃; for 18h;Inert atmosphere;	Tetrakistriphenylphosphinepalladium (0) (229 mg, 0.20 mmol) was added to a degassed mixture of 2-fluorophenylboronic acid (556 mg, 3.97 mmol), <strong>[2732-80-1]2-bromo-1-chloro-4-methoxybenzene</strong> (0.49 mL, 3.57 mmol), caesium carbonate (3.87 g, 11.9 mmol), water (5.0 mL) and dioxane (26.0 mL). The reaction was heated at 80 C. for 18 hours, cooled to room temperature and then partitioned between ethyl acetate (30.0 mL) and sat. aq. ammonium chloride (10.0 mL). The aqueous phase was separated and extracted with ethyl acetate (2×10 mL). The combined organic phases were washed with brine (5.0 mL), dried over MgSO4, filtered and evaporated to give a pale yellow oil. Column chromatography purification on silica, eluting with heptanes gave the title compound (749 mg, 88%) as a colourless oil.1HNMR (400 MHz, CDCl3): delta 3.81 (s, 3H, OMe), 6.87-6.89 (m, 2H, Ar), 7.15 (m, 1H, Ar), 7.21 (m, 1H, Ar), 7.31-7.41 (m, 3H, Ar).LCMS (4.5 min) Rt=3.00 minutes, No mass ion seen.

Reference： [1]Patent: US2012/10182,2012,A1 .Location in patent: Page/Page column 58

23
[ 2732-80-1 ]
[ 1354786-50-7 ]

Reference： [1]Patent: US2012/10182,2012,A1

24
[ 2732-80-1 ]
[ 1354787-27-1 ]

Reference： [1]Patent: US2012/10182,2012,A1

25
[ 2732-80-1 ]
[ 1354787-28-2 ]

Reference： [1]Patent: US2012/10182,2012,A1

26
[ 2732-80-1 ]
[ 1354787-29-3 ]

Reference： [1]Patent: US2012/10182,2012,A1

27
[ 2732-80-1 ]
[ 1354787-30-6 ]

Reference： [1]Patent: US2012/10182,2012,A1

28
[ 2732-80-1 ]
[ 137-07-5 ]
[ 1771-19-3 ]

Reference： [1]Chemical Communications,2012,vol. 48,p. 5367 - 5369

29
[ 1433772-22-5 ]
[ 2732-80-1 ]
[ 69751-85-5 ]

Reference： [1]European Journal of Organic Chemistry,2012,p. 6586 - 6593

30
[ 2732-80-1 ]
[ 75-36-5 ]
[ 1154415-17-4 ]

Yield	Reaction Conditions	Operation in experiment
99%	With aluminum (III) chloride; In carbon disulfide; for 1h;Reflux;	The <strong>[2732-80-1]2-bromo-1-chloro-4-methoxybenzene</strong> (25.0 g, 113 mmol) [Oakwood cat035670] was dissolved in carbon disulfide (250 mL), and the acetyl chloride (12 mL, 170 mmol) and aluminum trichloride (37.6 g, 282 mmol) were added. The reaction was heated to reflux and monitored by LC/MS. After heating for 1 h, the reaction became two layers. The reaction allowed to cool to room temperature and poured over ice. The slurry was extracted with ethyl acetate 3×, the combined organic layer was washed with brine, dried over magnesium sulfate and concentrated to give 1-(4-bromo-5-chloro-2-hydroxyphenyl)ethanone as a solid (28.0 g, 99%). 1H NMR (300 MHz, CDCl3) delta 12.12 (s, 1H), 7.78 (s, 1H), 7.31 (s, 1H), 2.62 (s, 3H).

Reference： [1]Patent: US2013/261101,2013,A1 .Location in patent: Paragraph 0561

31
[ 2732-80-1 ]
[ 1462921-14-7 ]

Reference： [1]Patent: US2013/261101,2013,A1

32
[ 2732-80-1 ]
[ 1462921-15-8 ]

Reference： [1]Patent: US2013/261101,2013,A1

33
[ 2732-80-1 ]
[ 1462921-16-9 ]

Reference： [1]Patent: US2013/261101,2013,A1

34
[ 2732-80-1 ]
[ 1462921-17-0 ]

Reference： [1]Patent: US2013/261101,2013,A1

35
[ 2732-80-1 ]
[ 1462921-18-1 ]

Reference： [1]Patent: US2013/261101,2013,A1

36
[ 2732-80-1 ]
[ 1462921-19-2 ]

Reference： [1]Patent: US2013/261101,2013,A1

37
[ 2732-80-1 ]
[ 1462921-20-5 ]

Reference： [1]Patent: US2013/261101,2013,A1

38
[ 2732-80-1 ]
[ 1462921-21-6 ]

Reference： [1]Patent: US2013/261101,2013,A1

39
[ 2732-80-1 ]
[ 1462921-22-7 ]

Reference： [1]Patent: US2013/261101,2013,A1

40
[ 2732-80-1 ]
[ 1462921-23-8 ]

Reference： [1]Patent: US2013/261101,2013,A1

41
[ 2732-80-1 ]
[ 1462921-24-9 ]

Reference： [1]Patent: US2013/261101,2013,A1

42
[ 5241-58-7 ]
[ 2732-80-1 ]
(S)-2-(2-chloro-5-methoxyphenylamino)-3-phenylpropionamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 120℃; for 48h;Inert atmosphere;	General procedure: To an oven-dry ground test tube equipped with a stir bar were added 1 mmol 2-bromoiodobenzene, 1mmolL-alaninamide, 3 mmol potassium carbonate and 5 mL DMF. The test tube was sealed with a rubber stopperand was evacuated and refilled with argon for three times. Then the test tube was stirred in an oil bathpreheated at 90? C for 48 hours. After the test tube was cooled to room temperature, the reaction wasquenched with water, and the reaction mixture was extracted with 20 mL ethyl acetate for three times. Thecombined organic layer was washed with 10 mL water and then saturated sodium chloride aqueous solution,and dried over anhydrous sodium sulfate. After filtration, the filtrate was condensed on a rotary evaporator invacuum. The resulting crude product was chromatographed on silica gel (300-400 mesh) with a 1:2 volumeratio mixed solution of ethyl acetate and petroleum ether as eluent to give a white solid L-N-phenylalaninamide.

Reference： [1]Tetrahedron Letters,2013,vol. 54,p. 6045 - 6048

43
[ 2732-80-1 ]
[ 716-79-0 ]
2-methoxybenzo[4,5]imidazo[1,2-f ]phenanthridine [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2013,vol. 11,p. 7966 - 7977

44
[ 2732-80-1 ]
(benzo[b]thiophen-3-yl)methylzinc chloride lithium chloride [ No CAS ]
[ 1599474-18-6 ]

Reference： [1]Organic Letters,2014,vol. 16,p. 2422 - 2425

45
[ 50448-95-8 ]
[ 2732-80-1 ]
C₁₈H₂₇ClO₃S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 75 - 82

46
[ 2732-80-1 ]
[ 59429-73-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 75 - 82

47
[ 2732-80-1 ]
C₁₉H₁₅Cl₃O₃S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 75 - 82

48
[ 2732-80-1 ]
C₂₂H₂₁Cl₃O₄S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 75 - 82

49
[ 2732-80-1 ]
C₂₄H₁₈Cl₃NO₃S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 75 - 82

50
[ 2732-80-1 ]
C₁₉H₁₄BrCl₃O₃S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 75 - 82

51
[ 2732-80-1 ]
C₂₄H₂₄Cl₃NO₄S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 75 - 82

52
[ 2732-80-1 ]
[ 132635-95-1 ]
(S)-2-(2-chloro-5-methoxybenzyl)pyrrolidine [ No CAS ]

Reference： [1]MedChemComm,2015,vol. 6,p. 1054 - 1064

53
[ 121-43-7 ]
[ 2732-80-1 ]
[ 141-43-5 ]
C₁₆H₁₈BCl₂NO₃ [ No CAS ]

Reference： [1]Chemical Communications,2015,vol. 51,p. 16084 - 16087

54
[ 2732-80-1 ]
2-chloro-5-methoxyphenylboronic acid [ No CAS ]

Reference： [1]Chemical Communications,2015,vol. 51,p. 16084 - 16087

55
[ 2732-80-1 ]
C₉H₁₁BrClNO [ No CAS ]

Reference： [1]ACS Chemical Neuroscience,2016,vol. 7,p. 1614 - 1619

56
[ 2732-80-1 ]
C₁₇H₁₇BrClNO₂ [ No CAS ]

Reference： [1]ACS Chemical Neuroscience,2016,vol. 7,p. 1614 - 1619

57
[ 2732-80-1 ]
C₁₇H₁₉BrClNO₂ [ No CAS ]

Reference： [1]ACS Chemical Neuroscience,2016,vol. 7,p. 1614 - 1619

58
[ 2732-80-1 ]
C₉H₇BrClNO₃ [ No CAS ]

Reference： [1]ACS Chemical Neuroscience,2016,vol. 7,p. 1614 - 1619

59
[ 4885-02-3 ]
[ 2732-80-1 ]
C₈H₆BrClO₂ [ No CAS ]

Reference： [1]ACS Chemical Neuroscience,2016,vol. 7,p. 1614 - 1619

60
[ 86-58-8 ]
[ 2732-80-1 ]
C₁₆H₁₂ClNO [ No CAS ]

Reference： [1]Chemistry - A European Journal,2017,vol. 23,p. 9996 - 10000

61
[ 96-96-8 ]
[ 2732-80-1 ]

Reference： [1]Chemistry - A European Journal,2017,vol. 23,p. 9996 - 10000

62
[ 2732-80-1 ]
4-chloro-3-(quinolin-8-yl)phenol [ No CAS ]

Reference： [1]Chemistry - A European Journal,2017,vol. 23,p. 9996 - 10000

63
[ 2732-80-1 ]
2,6-dibromo-4-chloro-3-(quinoline-8-yl)phenol [ No CAS ]
2,6-dibromo-4-chloro-3-(quinoline-8-yl)phenol [ No CAS ]

Reference： [1]Chemistry - A European Journal,2017,vol. 23,p. 9996 - 10000

64
[ 2732-80-1 ]
2,6-dibromo-4-chloro-3-(quinoline-8-yl)phenol [ No CAS ]

Reference： [1]Chemistry - A European Journal,2017,vol. 23,p. 9996 - 10000

65
[ 2732-80-1 ]
[ 768-35-4 ]
2-chloro-3'-fluoro-5-methoxy-1,1'-biphenyl [ No CAS ]