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Chemical Structure| 27503-81-7 Chemical Structure| 27503-81-7
Chemical Structure| 27503-81-7

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Ensulizole is a sulfonated UV absorber that effectively absorbs UVB and some UVA, providing protection against DNA damage and sun protection.

Synonyms: PBSA

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Product Details of Ensulizole

CAS No. :27503-81-7
Formula : C13H10N2O3S
M.W : 274.30
SMILES Code : O=S(C1=CC=C2C(NC(C3=CC=CC=C3)=N2)=C1)(O)=O
Synonyms :
PBSA
MDL No. :MFCD00053007
InChI Key :UVCJGUGAGLDPAA-UHFFFAOYSA-N
Pubchem ID :33919

Safety of Ensulizole

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Application In Synthesis of Ensulizole

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27503-81-7 ]

[ 27503-81-7 ] Synthesis Path-Downstream   1~1

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  • [ 7474-78-4 ]
  • [ 65-85-0 ]
  • [ 27503-81-7 ]
YieldReaction ConditionsOperation in experiment
With chloro-trimethyl-silane; In water; N,N-dimethyl-formamide; at 110℃; for 0.5h;Microwave irradiation; 3,4-Diaminobenzenesulfonic acid (18.82 g, 0.01 mol) and benzoic acid (12.21 g and 0.01 mol) were dissolved in DMF and water (1:1 vpercent) solution. Using trimethylsilyl chloride as the catalyst, the mixture was heated in the microwave reactor at 110°C for 0.5 h. After heating, it was adjusted to 10 of pH value. In the end, the precipitation was filtered and separated. The blocked crystal of the product was obtained on recrystallization. After removal of water molecules from the products, the characterizations were measured. 1H-NMR (dimethyl sulfoxide [DMSO]): 8.28 (d), 7.90 (s), 7.59 (d), 7.51 (d), 7.41 (s), 5 (s) ppm; 13C-NMR (DMSO): 152.9, 145.5, 140.2, 137.9, 134.7, 131.1, 129.2, 127.5, 120.7, 116.5, 113.2 ppm. Anal. calcd. for C13H10N2O3S (310.32): C, 50.31; H, 3.22; N, 9.02; S, 10.33; found C, 50.66; H, 3.81; N, 9.25; S, 10.79. IR spectrum (cm?1), 3375, 2857, 1632, 1601, 1568, 1514, 1496, 1375, 1212, 1089, 1030, 870, 777, 683, 614.
 

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