[ CAS No. 2830-53-7 ]

Name: 2830-53-7|1-(Benzyloxy)-2-bromo-4-methylbenzene|96%
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COA NMR CNMR HPLC LC-MS

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Product Details of [ 2830-53-7 ]

CAS No. :	2830-53-7	MDL No. :	MFCD09753753
Formula :	C₁₄H₁₃BrO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	277.16 g/mol	Pubchem ID :	-
Synonyms :

Safety of [ 2830-53-7 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362	UN#:	N/A
Hazard Statements:	H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 2830-53-7 ]

Downstream synthetic route of [ 2830-53-7 ]

[ 2830-53-7 ] Synthesis Path-Downstream 1~17

1
[ 6627-55-0 ]
[ 100-44-7 ]
[ 2830-53-7 ]

Yield	Reaction Conditions	Operation in experiment
72%	With potassium carbonate In acetonitrile Heating;
	With potassium carbonate In N,N-dimethyl-formamide
	With potassium carbonate

Reference： [1]Sanz, Roberto; Miguel, Delia; Martinez, Alberto; Perez, Antonio [Journal of Organic Chemistry, 2006, vol. 71, # 10, p. 4024 - 4027]
[2]Kametani; Okubo; Takano [Chemical and pharmaceutical bulletin, 1968, vol. 16, # 6, p. 1095 - 1097]
[3]Kametani,T.; Fukumoto,K. [Journal of the Chemical Society, 1964, p. 6141 - 6146]

2
[ 2830-53-7 ]
[ 115-19-5 ]
[ 163400-27-9 ]

Yield	Reaction Conditions	Operation in experiment
69%	With copper(l) iodide; triphenylphosphine; palladium dichloride In triethylamine; N,N-dimethyl-formamide

Reference： [1]Tsukayama, Masao [Heterocycles, 1997, vol. 45, # 6, p. 1131 - 1142]

3
[ 2830-53-7 ]
[ 155835-37-3 ]
[ 215929-27-4 ]

Yield	Reaction Conditions	Operation in experiment
61%	Stage #1: 1-(benzyloxy)-2-bromo-4-methylbenzene With magnesium In tetrahydrofuran Stage #2: (4R)-3-(3-phenyl-2-(E)-propenoyl)-4-phenyl-2-oxazolidinone With copper(I) bromide dimethylsulfide complex In tetrahydrofuran diastereoselective reaction;	1 4.8. General procedure for conjugate 1,4-addition of arylmagnesium bromides to cinnamic acid derivatives 2a-l in the presence of Cu(I) catalysts General procedure: Grignard reagent, prepared from 1-benzyloxy-2-bromo-4-methylbenzene (0.68g, 2.4mmol) and magnesium turnings (0.12g) in dry THF (10mL), was added to a cooled (-50°C) suspension of CuBr (71mg, 0.3equiv) in dry THF (3mL), then the temperature was allowed raise to -25°C and solution of cinnamide 2 (1.6mmol) in dry THF (4mL) was added keeping the temperature below -20°C. After the addition was completed the temperature was allowed to rise to room temperature and stirred overnight. The reaction mixture was quenched with 10% NH4Cl (10mL) and mixture was evaporated to remove all of the organic solvent. The aqueous layer was then extracted with ethyl acetate (3×25mL), and washed with 30ml of 17% NH4OH and 50ml of brine and dried over Na2SO4. Concentration in vacuo gave a crude product, which was purified by chromatography or crystallized. 4.8.1 (R)-3-[(R)-3-(2-Benzyloxy-5-methylphenyl)-3-phenylpro-pionyl]-4-phenyl-oxazolidin-2-one 8a. This compound was obtained from 2a (0.25g, 0.85mmol) in 0.26g amount (yield 61%) after chromatography (PE/EtOAc, 1.2:1) and further recrystallization of ether. White crystals; mp 116-117°C (Et2O); [α]D22=-72 (c 1.0, CHCl3); de 100%; Found: C, 77.50; H, 5.83; N, 2.79. C32H29NO4 requires C, 78.19; H, 5.95; N, 2.85%; 1H NMR (200MHz, CDCl3) δ 2.26 (s, 3H, CH3), 3.62 (dd, J=6.5, 16.8Hz, 1H, PhCHCH2), 3.89 (dd, J=8.9, 16.8Hz, 1H, PhCHCH2), 4.16 (dd, J=3.5, 8.8Hz, 1H, PhCHCH2), 4.50 (t, J=8.7Hz, 1H, NCH), 4.92 (s, 2H, PhCH2O), 5.02 (dd, J=6.5, 8.8Hz, 1H, NCHCH2), 5.28 (dd, J=3.5, 8.6Hz, 1H, NCHCH2), 6.71 (d, J=8.3Hz, 1H, 3(A)-aromH), 6.93 (dd, J=2.1, 8.3Hz, 1H, 4(A)-aromH), 7.06 (d, J=2.1Hz, 1H, 6(A)-aromH), 7.08-7.34 (m, 15H, aromH). 13C NMR (75MHz, CDCl3) δ 20.9, 40.0, 40.1, 57.7, 70.0, 70.2, 112.2, 125.7, 126.2, 127.4, 127.7, 127.9, 128.3, 128.4, 128.5, 128.6, 128.7, 129.2, 130.0, 132.0, 137.4, 139.1, 143.5, 153.9, 171.1.
	With copper(I) bromide dimethylsulfide complex; dimethylsulfide; magnesium 1) THF, reflux, 15 min; 2) THF, -50 deg C, 3 min; 3) THF, 10 deg C, 2 h; Yield given. Multistep reaction;

Reference： [1]Leitis, Zigmārs; Lūsis, Viesturs [Tetrahedron Asymmetry, 2016, vol. 27, # 17-18, p. 843 - 851]
[2]Andersson, Pher G.; Schink, Hans E.; Oesterlund, Krister [Journal of Organic Chemistry, 1998, vol. 63, # 22, p. 8067 - 8070]

4
[ 100-44-7 ]
[ 2830-53-7 ]
2-benzyl-6-bromo-4-methyl-phenol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With toluene

Reference： [1]Huston; Lewis [Journal of the American Chemical Society, 1931, vol. 53, p. 2379,2381]

5
[ 2830-53-7 ]
[ 220223-05-2 ]

Yield	Reaction Conditions	Operation in experiment
74%	Stage #1: 1-(benzyloxy)-2-bromo-4-methylbenzene With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In diethyl ether; hexane at -78℃; for 1h; Stage #2: With sulfur dioxide In diethyl ether; hexane at -78 - 20℃; for 1.25h; Stage #3: With N-chloro-succinimide; sodium phosphate In water; ethyl acetate for 1h; ice-cooling;

Reference： [1]Papageorgiou, George; Corrie, John E. T. [Tetrahedron, 1999, vol. 55, # 1, p. 237 - 254]

6
[ 2830-53-7 ]
[ 109588-48-9 ]
[ 834-25-3 ]

Yield	Reaction Conditions	Operation in experiment
1: 56% 2: 13%	With 2,2'-azobis(isobutyronitrile); 1,1,2,2-tetraphenyldisilane In m-xylene for 22h; Heating;
1: 42% 2: 10%	With azobis(2-cyanobutane); tri-n-butyl-tin hydride In cyclohexane Heating;

Reference： [1]Ryokawa, Atsushi; Togo, Hideo [Tetrahedron, 2001, vol. 57, # 28, p. 5915 - 5921]
[2]Bowman, Russell; Mann, Emma; Parr, Jonathan [Journal of the Chemical Society. Perkin Transactions 1 (2001), 2000, # 17, p. 2991 - 2999]

7
[ 6627-55-0 ]
[ 100-39-0 ]
[ 2830-53-7 ]

Yield	Reaction Conditions	Operation in experiment
100%	With potassium carbonate In acetone for 20h; Heating;
97%	With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 11h;	Synthesis of 1-(benzyloxy)-2-bromo-4-methylbenzene 2b To a stirred solution of the 2-bromo-4-methylphenol (0.5 g, 2.67 mmol, 1.0 equiv.),benzyl bromide (0.595 g, 3.48 mmol, 1.3 equiv.), and K2CO3 (0.739 g, 5.35 mmol, 2.0equiv.) in DMF (5 mL) was added at room temperature, then the reaction system wasstirred at 90 C. After 11 h, the reaction was completed by thin-layer chromatography(TLC). The mixture was diluted with EtOAc (12 mL), washed with saturated brine (10mL × 2). The organic layer was dried over anhydrous Na2SO4 and concentrated. Theresidue was purified by column chromatography on silica gel (200-300 m) with EtOAc/petroleum ether (v/v, 1:10) as the eluent to give the product 2b (716 mg, 97%, whitesolid).
91%	With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide

90%	With potassium carbonate In acetone for 4h; Reflux;	1.A To a solution of 2-bromo-4-methylphenol 32a (5 g, 26.7 mmol) in acetone (60 mL) was added K2CO3 (11 g, 80 mmol) followed by benzyl bromide (3.8 mL, 32 mmol). The mixture was heated to reflux for 4 hours, then was cooled to room temperature. Solid was removed via filtration and the filtrate was concentrated in vacuo. The residue was purified by column chromatography (5% EtO Ac/heptane) to give 6.7 g of Ha as a white semi-solid (yield 90%).
82%	With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 12h; Inert atmosphere;
77%	With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;	14.1 (1) Synthesis of 1-Benzyloxy-2-bromo-4-methylbenzene To a solution of 2-bromo-4-methylphenol (1.5 g, 8.0 mmol) in N,N-dimethylformamide (40 mL), potassium carbonate (1.32 g, 9.6 mmol) was added and furthermore benzyl bromide (1.05 mL, 8.8 mmol) was added thereto. The mixture solution was stirred at room temperature for 12 hours, and then water was added thereto and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution and dried (anhydrous magnesium sulfate), and then the solvent was distilled under reduced pressure. The obtained residue was purified by silica gel column chromatography [developing solution= ethyl acetate: n-hexane (1:4)] to obtain the title compound (1.72 g, 77%). 1H-NMR (CDCl3) δ: 2.30 (3H, s), 5.12 (2H, s), 6.82 (1H, d, J=8.4Hz), 6.99-7.03 (1H, m), 7.28-7.41 (4H, m), 7.45-7.48 (2H, m)
77%	With potassium carbonate In acetone for 4h; Reflux;	1.1.1 Step 1: The preparation of 1-(benzyloxy)-2-bromo-4-methylbenzene (compound 1) To a solution of 2-bromo-4-methylphenol (SM1, 20 g, 0.107 mol) in acetone (240 ml) were added (bromomethyl)benzene (SM2, 15.2 ml, 21.95 g, 0.128 mol) and K2CO3 (44.3 g, 0.321 mol). The mixture was heated to reflux for 4 hours, and was cooled to room temperature. The solution was poured into water (400 ml) and extracted with EA. The organic layer was washed with water for two times, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to obtain the crude product. The crude product was purified by column chromatography (PE: EA = 98: 2) to obtain the targetcompound 1 (23 g, 77.0 % yield).
36%	Stage #1: 2-bromo-p-cresol With sodium hydride In tetrahydrofuran for 0.5h; Heating; Stage #2: benzyl bromide In tetrahydrofuran for 4h; Heating; Further stages.;
	With potassium carbonate In acetone for 24h; Reflux;
	With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 12h;
	With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 12h;	3 1-(benzyloxy)-2-bromo-4-methylbenzene (3a) 1-(benzyloxy)-2-bromo-4-methylbenzene (3a) To a mixture of 2-bromo-4-methylphenol (5.0 g, 27 mmol) and K2CO3 (7.4 g, 53 mmol) in DMF (20 mL) was added benzyl bromide (3.5 mL, 29 mmol) at ambient temperature. It was stirred at 70° C., for 12 h. The mixture was poured into water (50 mL), extracted with EtOAc (150 mL), washed with water, brine, dried and concentrated. The residue was purified by column chromatography on silica gel eluting with hexanes/EtOAc (10:1) to give the title compound (3a).
	With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetonitrile at 65℃;	1-(benzyloxy)-2-bromo-4-methylbenzene 2-bromocresol (12.9 g, 68.9 mmol), benzyl bromide (9.0 mL, 75.8 mmol), potassium carbonate (28.5 g, 206 mmol), and TBAI (approx. 100 mg) were heated overnight at 65°C in acetonitrile. Once cool, the mixture was filtered and concentrated under reduced pressure. The benzylated product was used withoutfurther purification.

Reference： [1]Soegel, Sebastian; Tokunaga, Norihito; Sasaki, Keigo; Okamoto, Kazuhiro; Hayashi, Tamio [Organic Letters, 2008, vol. 10, # 4, p. 589 - 592]
[2]Hu, Nvdan; Kong, Wenlong; Li, Shengkun; Song, Baoan; Wang, Xia [European Journal of Medicinal Chemistry, 2022, vol. 227]
[3]Vyvyan, James R.; Loitz, Celeste; Looper, Ryan E.; Mattingly, Cheryl S.; Peterson, Emily A.; Staben, Steven T. [Journal of Organic Chemistry, 2004, vol. 69, # 7, p. 2461 - 2468]
[4]Current Patent Assignee: CONCERT PHARMACEUTICALS INC - WO2009/126844, 2009, A2 Location in patent: Page/Page column 25
[5]Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente [Organic Letters, 2010, vol. 12, # 15, p. 3498 - 3501]
[6]Current Patent Assignee: Chugai Pharmaceutical (in: Roche); ROCHE HOLDING AG - EP1783110, 2007, A1 Location in patent: Page/Page column 40
[7]Current Patent Assignee: HANGZHOU REX PHARMACEUTICAL - EP3476848, 2019, A1 Location in patent: Paragraph 0047-0048
[8]Bowman, Russell; Mann, Emma; Parr, Jonathan [Journal of the Chemical Society. Perkin Transactions 1 (2001), 2000, # 17, p. 2991 - 2999]
[9]Mondragón, Alexander; Monsalvo, Iván; Regla, Ignacio; Castillo, Ivan [Tetrahedron Letters, 2010, vol. 51, # 4, p. 767 - 770]
[10]Location in patent: scheme or table Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente [Organic Letters, 2011, vol. 13, # 20, p. 5711 - 5712]
[11]Current Patent Assignee: SHANGHAI FOSUN PHARMACEUTICAL (GROUP) CO., LTD.; Shanghai Institute of Materia Medica (in: CAS); CHINESE ACADEMY OF SCIENCES - US2014/128387, 2014, A1 Location in patent: Paragraph 0650; 0651
[12]Current Patent Assignee: EXXON MOBIL CORP - WO2019/27572, 2019, A1 Location in patent: Paragraph 00150

8
[ 93-51-6 ]
[ 2830-53-7 ]
2-benzyloxy-2'-methoxy-4',5'-dimethyldiphenyl ether [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
57%	With pyridine; copper(I) trifluoromethanesolfonate toluene complex; caesium carbonate at 110℃; for 24h;

Reference： [1]Xing, Xuechao; Padmanaban, Deepa; Yeh, Li-An; Cuny, Gregory D [Tetrahedron, 2002, vol. 58, # 39, p. 7903 - 7910]

9
[ 2830-53-7 ]
[ 180303-11-1 ]
1-Benzyloxy-4-methyl-2-(5-methyl-1-methylene-hex-4-enyl)-benzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 1-(benzyloxy)-2-bromo-4-methylbenzene With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; for 1.16667h; Stage #2: With zinc(II) chloride In tetrahydrofuran; diethyl ether; pentane at -78 - 20℃; Stage #3: Trifluoro-methanesulfonic acid 5-methyl-1-methylene-hex-4-enyl ester In tetrahydrofuran; diethyl ether; pentane for 24h; Heating;

Reference： [1]Vyvyan, James R.; Loitz, Celeste; Looper, Ryan E.; Mattingly, Cheryl S.; Peterson, Emily A.; Staben, Steven T. [Journal of Organic Chemistry, 2004, vol. 69, # 7, p. 2461 - 2468]

10
[ 3054-95-3 ]
[ 2830-53-7 ]
(E)-3-(2-(benzyloxy)-5-methylphenyl)acrylaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
41%	With palladium diacetate; potassium chloride; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 2.5h;

Reference： [1]Paquin, Jean-Francois; Defieber, Christian; Stephenson, Corey R. J.; Carreira, Erick M. [Journal of the American Chemical Society, 2005, vol. 127, # 31, p. 10850 - 10851]

11
[ 540-88-5 ]
[ 2830-53-7 ]
cis-3,5-dimethyl-3-hydroxy-2-phenyl-2,3-dihydrobenzo[b]furan [ No CAS ]
trans-3,5-dimethyl-3-hydroxy-2-phenyl-2,3-dihydrobenzo[b]furan [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 43% 2: 19%	Stage #1: 1-(benzyloxy)-2-bromo-4-methylbenzene With tert.-butyl lithium In tetrahydrofuran; pentane at -78 - -25℃; Stage #2: acetic acid tert-butyl ester In tetrahydrofuran; pentane at -78 - 20℃;

Reference： [1]Sanz, Roberto; Miguel, Delia; Martinez, Alberto; Perez, Antonio [Journal of Organic Chemistry, 2006, vol. 71, # 10, p. 4024 - 4027]

12
[ 540-88-5 ]
[ 2830-53-7 ]
[ 58110-77-3 ]

Yield	Reaction Conditions	Operation in experiment
53%	Stage #1: 1-(benzyloxy)-2-bromo-4-methylbenzene With tert.-butyl lithium In tetrahydrofuran; pentane at -78 - -25℃; Stage #2: acetic acid tert-butyl ester In tetrahydrofuran; pentane at -78 - 20℃; Stage #3: With hydrogenchloride In tetrahydrofuran; water; pentane at 20℃;

Reference： [1]Sanz, Roberto; Miguel, Delia; Martinez, Alberto; Perez, Antonio [Journal of Organic Chemistry, 2006, vol. 71, # 10, p. 4024 - 4027]

13
[ 4606-07-9 ]
[ 2830-53-7 ]
3-cyclopropyl-5-methyl-2-phenylbenzo[b]furan [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2006,vol. 71,p. 4024 - 4027

14
[ 2830-53-7 ]
[ 33513-42-7 ]
[ 53389-98-3 ]

Yield	Reaction Conditions	Operation in experiment
100%	Stage #1: 1-(benzyloxy)-2-bromo-4-methylbenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78 - 20℃; for 12h; Further stages.;

Reference： [1]Soegel, Sebastian; Tokunaga, Norihito; Sasaki, Keigo; Okamoto, Kazuhiro; Hayashi, Tamio [Organic Letters, 2008, vol. 10, # 4, p. 589 - 592]

15
[ 2830-53-7 ]
[ 863970-29-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 41 percent / Pd(OAc)2; K₂CO₃; KCl / n-Bu₄NOAc / dimethylformamide / 2.5 h / 90 °C 2: [Rh(C₂H₄)2Cl]2; chiral substituted bicyclo[2.2.2]octa-2,5-diene; aq. KOH / methanol / 1.25 h / 50 °C

Reference： [1]Paquin, Jean-Francois; Defieber, Christian; Stephenson, Corey R. J.; Carreira, Erick M. [Journal of the American Chemical Society, 2005, vol. 127, # 31, p. 10850 - 10851]

16
[ 2830-53-7 ]
(S)-3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropanal [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 41 percent / Pd(OAc)2; K₂CO₃; KCl / n-Bu₄NOAc / dimethylformamide / 2.5 h / 90 °C 2: [Rh(C₂H₄)2Cl]2; chiral substituted bicyclo[2.2.2]octa-2,5-diene; aq. KOH / methanol / 1.25 h / 50 °C

Reference： [1]Paquin, Jean-Francois; Defieber, Christian; Stephenson, Corey R. J.; Carreira, Erick M. [Journal of the American Chemical Society, 2005, vol. 127, # 31, p. 10850 - 10851]

17
[ 2830-53-7 ]
2-(1,5-dimethyl-hex-4-enyl)-1-hydroxy-4-methyl-benzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: tert-butyllithium / tetrahydrofuran; pentane / 1.17 h / -78 °C 1.2: zinc chloride / tetrahydrofuran; pentane; diethyl ether / -78 - 20 °C 1.3: Pd(PPh₃)4 / tetrahydrofuran; pentane; diethyl ether / 24 h / Heating 2.1: 0.920 g / lithium; ammonia / diethyl ether / 1.5 h / cooling

Reference： [1]Vyvyan, James R.; Loitz, Celeste; Looper, Ryan E.; Mattingly, Cheryl S.; Peterson, Emily A.; Staben, Steven T. [Journal of Organic Chemistry, 2004, vol. 69, # 7, p. 2461 - 2468]

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P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 2830-53-7 ]

Quality Control of [ 2830-53-7 ]

Related Doc. of [ 2830-53-7 ]

Product Details of [ 2830-53-7 ]

Safety of [ 2830-53-7 ]

Application In Synthesis of [ 2830-53-7 ]

[ 2830-53-7 ] Synthesis Path-Downstream 1~17

Related Functional Groups of [ 2830-53-7 ]

Bromides

Aryls

Ethers

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 2830-53-7 ]