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[ CAS No. 28732-79-8 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 28732-79-8
Chemical Structure| 28732-79-8
Structure of 28732-79-8 *Storage: {[proInfo.prStorage]}

Quality Control of [ 28732-79-8 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 28732-79-8 ]

SDS

Product Details of [ 28732-79-8 ]

CAS No. :28732-79-8MDL No. :MFCD06254345
Formula :C7H4ClN3Boiling Point :297.3°C at 760 mmHg
Linear Structure Formula :-InChI Key :N/A
M.W :165.58Pubchem ID :569039
Synonyms :

Computed Properties of [ 28732-79-8 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 28732-79-8 ]

Signal Word:WarningClassN/A
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301 P312-P302 P352-P304-P304 P340-P305 P351 P338-P312-P321-P330-P332 P313-P337 P313-P340-P362-P403-P403 P233-P405-P501UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 28732-79-8 ]

  • Downstream synthetic route of [ 28732-79-8 ]

[ 28732-79-8 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 21038-66-4 ]
  • [ 28732-79-8 ]
  • 2
  • [ 28732-79-8 ]
  • [ 373-44-4 ]
  • N,N'-bis-pyrido[2,3-d]pyrimidin-4-yl-octane-1,8-diamine [ No CAS ]
  • 4
  • [ 28732-79-8 ]
  • [ 96-96-8 ]
  • C14H11N5O3 [ No CAS ]
  • 5
  • [ 28732-79-8 ]
  • 7-methoxy-4-(pyrido[2,3-d]pyrimidin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one [ No CAS ]
  • 6
  • [ 28732-79-8 ]
  • C16H14ClN5O2 [ No CAS ]
  • 7
  • [ 28732-79-8 ]
  • C14H13N5O [ No CAS ]
  • 8
  • [ 28732-79-8 ]
  • methyl 2-(aminomethyl)-5,6-dihydroxypyrimidine-4-carboxylate hydrochloride [ No CAS ]
  • C14H12N6O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: Amine 38b (1.1-1.3eq) and Et3N (3.0eq) were dissolved in dry DMSO (~2.0mL per 0.15 mmol 38b) and stirred at rt for 5min. The aryl chloride 37 (1.0eq; dissolved in 1.0mL dry dioxane) was then added and the mixture was heated at 100 C for 1h (under Ar balloon). The reaction was cooled to rt, concentrated in vacuo, added with H2O (to crash out the product), and then filtered. Crude product 39 was purified by tritration. Typical isolated yield was ~50-70%. When R6 of 39 was bromide, Suzuki cross-coupling was used to introduce several aryl groups at the R6 position, as previously described; product was purified by trituration.
  • 9
  • [ 28732-79-8 ]
  • methyl 2-(aminomethyl)-5,6-dihydroxypyrimidine-4-carboxylate hydrochloride [ No CAS ]
  • 5,6-dihydroxy-2-((pyrido[2,3-d]pyrimidin-4-ylamino)methyl)pyrimidine-4-carboxylic acid [ No CAS ]
  • 10
  • [ 28732-79-8 ]
  • [ 924907-34-6 ]
  • [ 1201580-99-5 ]
Historical Records

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[ 28732-79-8 ]

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