[ CAS No. 2885-02-1 ] {[proInfo.proName]}

Name: 2885-02-1|(S)-Butyl 2-aminopropanoate|97%
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Quality Control of [ 2885-02-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 2885-02-1 ]

SDS Specification

Alternatived Products of [ 2885-02-1 ]

Product Details of [ 2885-02-1 ]

CAS No. :	2885-02-1	MDL No. :	MFCD12796122
Formula :	C₇H₁₅NO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	RJJXSCQQRYCPLW-LURJTMIESA-N
M.W :	145.20	Pubchem ID :	13783303
Synonyms :		Chemical Name :	(S)-Butyl 2-aminopropanoate

Calculated chemistry of [ 2885-02-1 ] Expand+

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.86
Num. rotatable bonds :	5
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	39.76
TPSA :	52.32 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.58 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.98
Log Po/w (XLOGP3) :	0.86
Log Po/w (WLOGP) :	0.68
Log Po/w (MLOGP) :	0.75
Log Po/w (SILICOS-IT) :	0.57
Consensus Log Po/w :	0.97

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-0.95
Solubility :	16.2 mg/ml ; 0.112 mol/l
Class :	Very soluble
Log S (Ali) :	-1.54
Solubility :	4.17 mg/ml ; 0.0287 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.23
Solubility :	8.65 mg/ml ; 0.0596 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.01

Safety of [ 2885-02-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P305+P351+P338	UN#:	N/A
Hazard Statements:	H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 2885-02-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 2885-02-1 ]
Downstream synthetic route of [ 2885-02-1 ]

[ 2885-02-1 ] Synthesis Path-Upstream 1~5

1
[ 1534344-81-4 ]
[ 2885-02-1 ]

Reference： [1] Amino Acids, 2014, vol. 46, # 2, p. 367 - 374

2
[ 117402-81-0 ]
[ 2885-02-1 ]

Reference： [1] Organic and Biomolecular Chemistry, 2012, vol. 10, # 2, p. 339 - 345

3
[ 56-41-7 ]
[ 2885-02-1 ]

Reference： [1] Journal of the American Chemical Society, 1952, vol. 74, p. 1096

4
[ 56-41-7 ]
[ 71-36-3 ]
[ 2885-02-1 ]

Reference： [1] Journal of Organic Chemistry, 1996, vol. 61, # 8, p. 2829 - 2838

5
[ 10065-72-2 ]
[ 71-36-3 ]
[ 2885-02-1 ]

Reference： [1] Tetrahedron, 1987, vol. 43, # 4, p. 771 - 778

[ 2885-02-1 ] Synthesis Path-Downstream 1~26

1
[ 56-41-7 ]
[ 2885-02-1 ]

Reference： [1]Journal of the American Chemical Society,1952,vol. 74,p. 1096

2
[ 2885-02-1 ]
[ 2749-11-3 ]

Reference： [1]Journal of the American Chemical Society,1952,vol. 74,p. 1096

3
[ 2885-02-1 ]
[ 108-24-7 ]
[ 2256-78-2 ]

Reference： [1]Tetrahedron,1987,vol. 43,p. 771 - 778

4
[ 10065-72-2 ]
[ 71-36-3 ]
[ 2885-02-1 ]

Reference： [1]Tetrahedron,1987,vol. 43,p. 771 - 778

5
[ 2885-02-1 ]
[ 2270-59-9 ]
[ 176239-72-8 ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 2829 - 2838

6
[ 56-41-7 ]
[ 71-36-3 ]
[ 2885-02-1 ]

Yield	Reaction Conditions	Operation in experiment
1.36 g	With thionyl chloride; for 5.5h;Reflux;	1) Add L-alanine (1.00g) to n-butanol (8.32g),At room temperature was added dropwise thionyl chloride (1.60 g) under reflux for 5.5 h after completion of dropping,Concentrate under reduced pressure, the residue is adjusted to neutral pH with potassium bicarbonate solution,Dichloromethane extraction (50mL) 3 times, combined dichloromethane layers,It was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.L-alanine n-butyl ester (1.36 g) was obtained.

Reference： [1]Chemical Communications,2019,vol. 56,p. 161 - 164
[2]Journal of Organic Chemistry,1996,vol. 61,p. 2829 - 2838
[3]Patent: CN110938095,2020,A .Location in patent: Paragraph 0058-0060

7
C₅₀H₆₈N₂O₂₀ [ No CAS ]
[ 2885-02-1 ]
C₅₆H₈₈N₂O₁₈ [ No CAS ]

Reference： [1]Russian Journal of Bioorganic Chemistry,2004,vol. 30,p. 148 - 153

8
[ 1001057-28-8 ]
[ 2885-02-1 ]
[ 1001057-31-3 ]

Yield	Reaction Conditions	Operation in experiment
	With 2,2'-dipyridyldisulphide; triethylamine; triphenylphosphine;	Diacid 8 is then converted to the bis amidate prodrug 9 according to the procedure described in Scheme 1.

Reference： [1]Patent: WO2008/5542,2008,A2 .Location in patent: Page/Page column 257

9
[ 2885-02-1 ]
[ 176239-76-2 ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 2829 - 2838

10
[ 2885-02-1 ]
[ 176239-88-6 ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 2829 - 2838

11
[ 2885-02-1 ]
C₁₀H₁₁Cl₂N₂O₂PS₂ [ No CAS ]
[ 347870-08-0 ]

Reference： [1]Journal of Medicinal Chemistry,2008,vol. 51,p. 4331 - 4339

12
[ 110-52-1 ]
[ 2885-02-1 ]
[ 1353757-66-0 ]

Reference： [1]Organic and Biomolecular Chemistry,2012,vol. 10,p. 339 - 345

13
[ 2885-02-1 ]
(R,E)-n-butyl 2-methyl-2-(pyrrolidin-1-yl)-4-(p-toluenesulfonyl)but-3-enoate [ No CAS ]
[ 1353757-51-3 ]

Reference： [1]Organic and Biomolecular Chemistry,2012,vol. 10,p. 339 - 345

14
[ 117402-81-0 ]
[ 2885-02-1 ]

Reference： [1]Organic and Biomolecular Chemistry,2012,vol. 10,p. 339 - 345

15
[ 1534344-81-4 ]
[ 2885-02-1 ]

Reference： [1]Amino Acids,2014,vol. 46,p. 367 - 374

16
[ 2885-02-1 ]
[ 770-12-7 ]
C₁₃H₁₉ClNO₄P [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 1836 - 1844

17
[ 2885-02-1 ]
[ 770-12-7 ]
[ 1375071-01-4 ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 1836 - 1844

18
[ 2885-02-1 ]
[ 770-12-7 ]
[ 1442452-21-2 ]

Reference： [1]Patent: WO2015/34420,2015,A1
[2]Patent: WO2015/56213,2015,A1

19
[ 2885-02-1 ]
[ 770-12-7 ]
(2S)-butyl 2-((chloro(phenoxy)phosphoryl)amino)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In dichloromethane; at -20 - 20℃; for 1.5h;	Phenyl dichlorophosphate (12.4 mL, 83.1 mmol) was added to a cooled (-20 00) slurry of (S)butyl 2-aminopropanoate (26.4 g, 83.1 mmol) in DCM (200 mL). The mixture was stirred for 10mm then Et3N (25.5 mL, 183 mmol) was added dropwise for 15mm The mixture was stirred at -20 C for 1 h then at 0 C for 30 mm. The mixture was kept cooled in an ice-bath and pentafluorophenol (15.3 g, 0,08 mol) was added followed by a dropwise addition of Et3N (11 .6 mL, 0.08 mol). The mixture was stirred over night and slowly taken to 20 C. Diethyl ether was added and the mixture was filtered through Celite, concentrated and purified by columnchromatography on silica gel eluted with petroleum ether EtOAc (9:1 -> 8:2). Appropriatefractions were pooled, concentrated and crystallized from petroleum etherEtOAc which gavethe pure P-stereoisomer of the title compound as a white solid (2.23 g, 5.8%).
	With triethylamine; In dichloromethane; at -20 - 0℃; for 1.91h;	Phenyl dichlorophosphate (12.4 mL, 83.1 mmol) was added to a cooled (-20 C) slurry of (S)20 butyl 2-aminopropanoate (26.4 g, 83.1 mmcl) in dichloromethane (200 mL). The mixture wasstirred for 10 mm then Et3N (25.5 mL, 183 mmcl) was added dropwise for 15 mm. The mixture was stirred at -20 C for lh then at 0 C for 30 mm. The mixture was kept cooled in an ice-bath and perfluorophenol (15.3 g, 0,08 mol) was added followed by a dropwise addition of Et3N (11.6 mL, 0.08 mol). The mixture was stirred over night and slowly taken to 20 00 Diethyl ether wasadded and the mixture was filtered through Celite, concentrated and purified by column chromatography on silica gel eluted with petroleum ether EtOAc (9:1 -> 8:2). Appropriate fractions were pooled, concentrated and crystallized from petroleum ether EtOAc (9:1) which gave the pure P-stereoisomer of the title compound as a white solid (2.23 g, 5.8%).

Reference： [1]Patent: WO2015/34420,2015,A1 .Location in patent: Page/Page column 68; 69
[2]Patent: WO2015/56213,2015,A1 .Location in patent: Page/Page column 70; 71

20
[ 2885-02-1 ]
[ 771-61-9 ]
[ 770-12-7 ]
[ 1442452-21-2 ]

Yield	Reaction Conditions	Operation in experiment
5.8%		Phenyl dichlorophosphate (12.4 ml_, 83.1 mmol) was added to a cooled (-20 C) slurry of (S)- butyl 2-aminopropanoate (26.4 g, 83.1 mmol) in dichloromethane (200 ml_). The mixture was stirred for 10 min then Et3N (25.5 ml_, 183 mmol) was added dropwise for 15 min. The mixture was stirred at -20 C for 1 h then at 0 C for 30 min. The mixture was kept cooled in an ice-bath and perfluorophenol (15.3 g, 0,08 mol) was added followed by a dropwise addition of Et3N (1 1 .6 ml_, 0.08 mol). The mixture was stirred over night and slowly taken to 20 C. Diethyl ether was added and the mixture was filtered through Celite, concentrated and purified by column chromatography on silica gel eluted with petroleum ether/ EtOAc (9:1 -> 8:2). Appropriate fractions were pooled, concentrated and crystallized from petroleum ether EtOAc (9:1 ) which gave the pure phosphorus stereoisomer of the title compound as a white solid (2.23 g, 5.8%).

Reference： [1]Patent: WO2016/30335,2016,A1 .Location in patent: Page/Page column 50

21
[ 2885-02-1 ]
3,5-diamino-4-fluorobenzoic acid [ No CAS ]
C₁₄H₂₀FN₃O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
46.3%	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 72.0h;	3,5-diamino-4-fluorobenzoic acid (0.5 g, 2.94 mmol)And <strong>[2885-02-1](S)-butyl 2-aminopropionate</strong> (0.53 g, 2.94 mmol) was dissolved in 25 mL of dichloromethane.After adding Et3N (3mL),HOBt (10 mg), EDCI (1.12 g, 5.88 mmol),The reaction was overnight.After that, the reaction solution was washed with water, dried with Na 2 SO 4 , and subjected to column chromatography.(S)-tert-Butyl 2-(3,5-diamino-4-fluorobenzoyl)propionate (0.4 g, 46.3%).

Reference： [1]Patent: CN108218803,2018,A .Location in patent: Paragraph 0090; 0097; 0100; 0101

22
[ 2885-02-1 ]
C₂₂H₂₃ClN₇O₅P [ No CAS ]
butyl ((S)-((1-((2-amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)(2-chloro-4-(2,4-dimethyl-6-oxopyrimidin-1(6H)-yl)phenoxy)phosphoryl)-L-alaninate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
24%		Mix compound 18c (9.3 mmol) with 10 mL acetonitrile.Additional thionyl chloride (21.0 mmol) was added.Heat to about 80 C, after the solution is clarified, dilute the solvent under reduced pressure.The resulting residue was cooled and dissolved in 25 mL of dichloromethane.Then cooled to -20 C and added the corresponding (L)-alanine ester (18.6 mmol) in dichloromethane (15 mL) and2.4 mL of triethylamine was slowly warmed to room temperature. After the reaction is completed,Wash with 10% sodium dihydrogen phosphate solution, and dry the organic layer over anhydrous sodium sulfate.Concentrated under reduced pressure, and the obtained concentrate was purified by column chromatography.The obtained compound was subjected to HPLC separation by the method of Step 2 of Example 27.The corresponding chiral compound is obtained.Target compound 38a (R3 = n-butyl):White solid, yield 24%

Reference： [1]Patent: CN109535200,2019,A .Location in patent: Paragraph 0418-0421

23
[ 2885-02-1 ]
C₂₄H₂₅N₆O₅P [ No CAS ]
isopropyl ((S)-((1-((2-amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)(4-(2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridin-1-yl)phenoxy)phosphoryl)-L-alaninate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
16%		Mix compound 19a (9.3 mmol) with 10 mL acetonitrile.Additional thionyl chloride (21.0 mmol) was added.Heat to about 80 C, after the solution is clarified, dilute the solvent under reduced pressure.The resulting residue was cooled and dissolved in 25 mL of dichloromethane.Then cooled to -20 C, respectively, a solution of (L)-alanine isopropyl ester (18.6 mmol) in dichloromethane (15 mL) and 2.4 mLTriethylamine slowly warmed to room temperature. After the reaction is completed,Wash with 10% sodium dihydrogen phosphate solution, and dry the organic layer over anhydrous sodium sulfate.Concentrated under reduced pressure, and the obtained concentrate was purified by column chromatography.The obtained compound was isolated by HPLC to give the chiral compound 39a.White solid, yield 16%

Reference： [1]Patent: CN109535200,2019,A .Location in patent: Paragraph 0424-0426

24
[ 2885-02-1 ]
C₂₅H₂₃N₆O₅P [ No CAS ]
isopropyl ((S)-((1-((2-amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)(4-(2-oxyquinolin-1(2H)-yl)phenoxy)phosphoryl)-L-alaninate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
19%		Mix compound 19b (9.3 mmol) with 10 mL acetonitrile.Additional thionyl chloride (21.0 mmol) was added.Heat to about 80 C, after the solution is clarified, dilute the solvent under reduced pressure.The resulting residue was cooled and dissolved in 25 mL of dichloromethane.Then cooled to -20 C, respectively, a solution of (L)-alanine isopropyl ester (18.6 mmol) in dichloromethane (15 mL) and 2.4 mLTriethylamine slowly warmed to room temperature. After the reaction is completed,Wash with 10% sodium dihydrogen phosphate solution, and dry the organic layer over anhydrous sodium sulfate.Concentrated under reduced pressure, and the obtained concentrate was purified by column chromatography.The obtained compound was subjected to HPLC preparative separation by the method of Step 2 of Example 27 to give a chiral compound 39b.White solid, yield 19%,

Reference： [1]Patent: CN109535200,2019,A .Location in patent: Paragraph 0427-0429

25
[ 2885-02-1 ]
C₂₁H₂₃N₆O₅P [ No CAS ]
butyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(4-(5-methyl-2-oxopyridine-1(2H)-yl)phenoxy)phosphoryl)-L-alaninate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
23%		Compound 6a (9.3 mmol) and 10 mL of acetonitrile were mixed, followed by thionyl chloride (21.0 mmol).The mixture was heated to about 80 C. After the solution was clarified, the solvent was evaporated under reduced pressure, and the obtained residue was cooled and then dissolved in 25 mL of dichloromethane.Then cooled to -20 C, respectively, a solution of <strong>[2885-02-1](L)-alanine butyl ester</strong> (18.6 mmol) in dichloromethane (15 mL) and 2.4 mL triEthylamine was slowly warmed to room temperature. After the reaction is completed, it is washed with 10% sodium dihydrogen phosphate solution, and the organic layer is passed through anhydrous sodium sulfate.Drying, concentration under reduced pressure, the obtained concentrate was purified by column chromatography, and the obtained compound was subjected to the procedure ofIsolation by HPLC gave Compound 20b (yield: 23%,

Reference： [1]Patent: CN109535200,2019,A .Location in patent: Paragraph 0306-0308

26
[ 2885-02-1 ]
C₂₁H₂₂FN₆O₅P [ No CAS ]
butyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(2-fluoro-4-(5-methyl-2-oxopyridine-1(2H)-yl)phenoxy)phosphoryl)-L-alaninate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
24%		Compound 6b (9.3 mmol) and 10 mL of acetonitrile were mixed, followed by thionyl chloride (21.0 mmol).The mixture was heated to about 80 C. After the solution was clarified, the solvent was evaporated under reduced pressure, and the obtained residue was cooled and then dissolved in 25 mL of dichloromethane.Then cooled to -20 C and added the corresponding (L)-alanine ester (18.6 mmol) in dichloromethane (15 mL) and2.4 mL of triethylamine was slowly warmed to room temperature. After the reaction is completed, it is washed with 10% sodium dihydrogen phosphate solution, and the organic layer is dried.Drying over sodium sulfate and concentrating under reduced pressure, the obtained concentrate was purified by column chromatography, andThe method was isolated by HPLC to give the corresponding chiral compound.Target compound 21b (R3 = n-butyl): white solid (yield: 24%),

Reference： [1]Patent: CN109535200,2019,A .Location in patent: Paragraph 0314-0317

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Isomers

Technical Information

• 1,4-Addition of an Amine to a Conjugated Enone • 1,4-Addition of an Amine to a Conjugated Enone • Acyl Group Substitution • Alcohols Convert Acyl Chlorides into Esters • Alcoholysis of Anhydrides • Amides Can Be Converted into Aldehydes • Amine Synthesis from Nitriles • Amine Synthesis from Nitriles • Amines Convert Acyl Chlorides into Amides • Amines Convert Esters into Amides • Azide Reduction by LiAlH4 • Azide Reduction by LiAlH4 • Basicity of Amines • Bouveault-Blanc Reduction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Catalytic Hydrogenation • Chan-Lam Coupling Reaction • Chichibabin Reaction • Claisen Condensations Produce β-Dicarbonyl Compounds • Claisen Condensations Produce β-Dicarbonyl Compounds • Complex Metal Hydride Reductions • Convert Esters into Aldehydes Using a Milder Reducing Agent • Decarboxylation of 3-Ketoacids Yields Ketones • Deprotection of Cbz-Amino Acids • Diazotization Reaction • DIBAL Attack Nitriles to Give Ketones • Enamine Formation • Ester Cleavage • Ester Hydrolysis • Formation of an Amide from an Amine and a Carboxylic Acid • Formation of an Amide from an Amine and a Carboxylic Acid • Grignard Reagents Transform Esters into Alcohols • Hantzsch Pyridine Synthesis • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hofmann Elimination • Hofmann Rearrangement • Hydride Reductions • Hydrolysis of Imines to Aldehydes and Ketones • Imine Formation from Amines and Aldehydes or Ketones • Ketones Undergo Mixed Claisen Reactions to Form β-Dicarbonyl Compounds • Leuckart-Wallach Reaction • Mannich Reaction • Methylation of Ammonia • Methylation of Ammonia • Nitrosation of Amines • Peptide Bond Formation with DCC • Petasis Reaction • Preparation of Amines • Preparation of LDA • Reactions of Amines • Reactions with Organometallic Reagents • Reduction of an Amide to an Amine • Reduction of an Amide to an Amine • Reduction of an Ester to an Alcohol • Reduction of an Ester to an Aldehyde • Reductive Amination • Reductive Amination • Ring Opening of Azacyclopropanes • Ring Opening of Azacyclopropanes • Ring Opening of Oxacyclobutanes • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Vilsmeier Reagent • Strecker Synthesis • Synthesis of 2-Amino Nitriles • The Cycloaddition of Dienes to Alkenes Gives Cyclohexenes • Transesterification • Ugi Reaction

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Ghs Precautionary Statements

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Code	Phrase
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P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	Inquiry	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ item.pr_usastock ]}		{[ item.pr_chinastock ]}	{[ item.pr_remark ]}

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 2885-02-1 ] {[proInfo.proName]}

Quality Control of [ 2885-02-1 ]

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Medicinal Chemistry

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Application In Synthesis of [ 2885-02-1 ]

[ 2885-02-1 ] Synthesis Path-Upstream 1~5

[ 2885-02-1 ] Synthesis Path-Downstream 1~26

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Related Functional Groups of [ 2885-02-1 ]

Amino Acid Derivatives

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[ 2885-02-1 ]

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