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[ CAS No. 2960-55-6 ] {[proInfo.proName]}

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Chemical Structure| 2960-55-6
Chemical Structure| 2960-55-6
Structure of 2960-55-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 2960-55-6 ]

CAS No. :2960-55-6 MDL No. :
Formula : C15H11NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :253.25 Pubchem ID :-
Synonyms :

Safety of [ 2960-55-6 ]

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Application In Synthesis of [ 2960-55-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2960-55-6 ]

[ 2960-55-6 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 2960-55-6 ]
  • [ 69218-56-0 ]
  • [ 131081-22-6 ]
YieldReaction ConditionsOperation in experiment
57% With sodium hydroxide In ethanol for 6h; Heating;
  • 2
  • [ 2960-55-6 ]
  • [ 64882-50-4 ]
  • [ 98124-35-7 ]
YieldReaction ConditionsOperation in experiment
76% With sodium hydroxide In ethanol for 1h; Heating;
  • 3
  • [ 619-73-8 ]
  • [ 6048-29-9 ]
  • [ 2960-55-6 ]
YieldReaction ConditionsOperation in experiment
95% With [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydroxide; copper(ll) bromide In formamide; acetonitrile at 65℃; for 24h; Schlenk technique; diastereoselective reaction; α,β-Unsaturated Esters 3, α,β-Unsaturated Ketones 4, and α,β-Unsaturated Nitriles 5; General Procedure General procedure: Alcohol (1 mmol), phosphonium salt (1.1 mmol), NaOH (1.1 mmol),CuBr2 (5 mol%), 2,2′-bipy (5 mol%), and TEMPO (5 mol%) were mixed in MeCN and HCONH2 (1:1, 2 mL) in a 100-mL Schlenk tube with an air balloon, and the mixture was stirred at 65 °C for 24 h (monitoring by TLC and/or GC-MS). After completion, product was purified by column chromatography (EtOAc and petroleum ether).
70% With manganese(IV) oxide; sodium hydroxide In dichloromethane at 20℃; for 20h;
  • 4
  • [ 555-16-8 ]
  • [ 536-74-3 ]
  • [ 2960-55-6 ]
YieldReaction ConditionsOperation in experiment
94% With 1-butyl-3-methyl-1H-imidazolium 4-methylbenzenesulfonate; water; hydrogen bromide at 100℃; for 12h;
93% With phosphonic Acid In water at 110℃; for 24h; Schlenk technique; Green chemistry; Chalcone (3a); Typical Procedure General procedure: PhC≡CH (1a; 0.5 mmol), PhCHO (2a; 0.6 mmol), and 50% aq H3PO4 (0.5 mmol) were added to a 5 mL Schlenk tube, and the mixture was vigorously stirred at 110 °C for 24 h. The mixture was then cooled tor.t. and EtOAc (20 mL) was added. The solution was washed with water (2 × 6 mL) and the organic phase was dried (MgSO4), concentrated, and purified by column chromatography [silica gel, EtOAc-PE (1:20)] to give a pale-yellow solid
71% With ytterbium(III) triflate at 90℃; for 12h;
38% With tin(ll) chloride; butan-1-ol In nitromethane at 80℃; for 3h; stereoselective reaction;
35% With amberlyst-15(R) In dichloromethane at 20℃; for 24h;

  • 5
  • [ 1772-43-6 ]
  • [ 2960-55-6 ]
  • C21H22N2O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% Stage #1: 2,4,4-trimethyl oxazoline With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: With zinc(II) chloride In tetrahydrofuran at -78 - 0℃; for 0.75h; Stage #3: (E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one In tetrahydrofuran at -78 - 20℃; Further stages.;
  • 6
  • [ 1117-19-7 ]
  • [ 2960-55-6 ]
  • [ 1012919-00-4 ]
YieldReaction ConditionsOperation in experiment
98% With 4 A molecular sieve In toluene at 25℃; for 7h;
  • 7
  • [ 2960-55-6 ]
  • [ 6752-16-5 ]
  • 4-(4-nitrophenyl)-2-phenylpyrido[2’,3’:3,4]pyrazolo[1,5-a]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With cholin hydroxide; In neat (no solvent); at 80℃; for 1h;Green chemistry; General procedure: ChOH (1 mmol) was added to a mixture of <strong>[6752-16-5]1H-pyrazolo[3,4-b]pyridin-3-amine</strong> (1,1.0 mmol) and (2E)-1,3-diphenylprop-2-en-1-one (2a, 1.0 mmol) in a 10-mL reaction flask equipped with a magnetic stirrer. The resulting mixture was stirred for the appropriate time at 80 C. After completion of the reaction (confirmed by TLC, hexane:EtOAc 1:1), 2 mL of water was added and stirred 60 for minutes at room temperature. The solid product was filtered and washed with water. The obtained crude product was recrystallized from ethanol to yield the pure product 3a. The same method was adopted for the synthesis of all the targeted products 3a-3aj.
  • 8
  • [ 2510-03-4 ]
  • [ 2960-55-6 ]
  • 2-((S)-2-((R)-1-(4-nitrophenyl)-3-oxo-3-phenylpropyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
62% Stage #1: (E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one With 9-amino-9-deoxy-epiquinine In 2-methyltetrahydrofuran at 20℃; for 0.5h; Green chemistry; Stage #2: 1,2,3,4-tetrahydro-1-naphthylidene malononitrile In 2-methyltetrahydrofuran at 20℃; for 0.25h; Green chemistry; Stage #3: With trifluoroacetic acid In 2-methyltetrahydrofuran at 20℃; for 96h; Green chemistry; stereoselective reaction; 7 4.3. Synthesis of Michael adducts 4a-x General procedure: In a 10 mL vial was added catalyst 3a (24 mg, 0.075 mmol), chalcone 1a (104 mg, 0.5 mmol) and 2-MeTHF (2.5 mL). This mixture was stirred for 30 min and then added α,α-dicyanoolefin 2a (146 mg, 0.75 mmol). After 15 min, TFA (5.74 μL, 0.075 mmol) was added and the reaction mixture was stirred for 4 days at room temperature.
  • 9
  • [ 6290-05-7 ]
  • [ 2960-55-6 ]
  • C23H20N2O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% With copper diacetate; triethylamine; In N,N-dimethyl-formamide; at 100℃; for 8h; (E)-3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one (0.0575 g, 0.25 mmol) was added to a 25 mL reaction tube.<strong>[6290-05-7]Diethyl iminodiacetate</strong> (0.0945 g, 0.5 mmol), Et3N (0.0253 g, 0.25 mmol) and Cu(OAc) 2 (0.0996 g, 0.50 mmol),It was then reacted in DMF (1.0 mL) at 100 C for 8 h. After the end of the reaction by TLC,Extract with 10 mL of a saturated aqueous solution of sodium chloride and ethyl acetate (3×10 mL).After the organic layers were combined and dried over anhydrous sodium sulfate, the solvent was removed by a rotary evaporator, and finally subjected to column chromatography (eluent was a mixture of petroleum ether and ethyl acetate in a volume ratio of 2:1).The target compound was obtained in 94% yield as a yellow solid.
  • 10
  • [ 636-98-6 ]
  • [ 768-03-6 ]
  • [ 2960-55-6 ]
YieldReaction ConditionsOperation in experiment
85% With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h; General procedure for Pd/Cu ASEP catalyzed Mizoroki-Heck coupling General procedure: Aryl halide (1.0 mmol), alkene (1.2 mmol), K2CO3 (2.0 mmol), Pd/CuASEP (0.130 g,Pd or Cu 1 mol %) and 5mL of certain solvent were added into a 50mL round-bottomflask. The reaction mixture was stirred at 80 C for 3 h. After completion of the reaction(monitored using TLC), the reaction mixture was cooled to room temperature.10 F. ARYANASABThe catalyst was separated by centrifugation, washed with ethyl acetate (25 mL), vacuumdried and kept for the next reaction. The reaction mixture was then extracted withEtOAc (310 mL), and the combined organic layer was dried with anhydrous sodiumsulfate. The solvent was removed under vacuum, and the residue was purified by flashchromatography or by recrystallization using ethyl acetate and hexanes to give thedesired product.
85% With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h; General procedure for Pd/Cu ASEP catalyzed Mizoroki-Heck coupling General procedure: Aryl halide (1.0 mmol), alkene (1.2 mmol), K2CO3 (2.0 mmol), Pd/CuASEP (0.130 g,Pd or Cu 1 mol %) and 5mL of certain solvent were added into a 50mL round-bottomflask. The reaction mixture was stirred at 80 C for 3 h. After completion of the reaction(monitored using TLC), the reaction mixture was cooled to room temperature. The catalyst was separated by centrifugation, washed with ethyl acetate (25 mL), vacuumdried and kept for the next reaction. The reaction mixture was then extracted withEtOAc (310 mL), and the combined organic layer was dried with anhydrous sodiumsulfate. The solvent was removed under vacuum, and the residue was purified by flashchromatography or by recrystallization using ethyl acetate and hexanes to give thedesired product.
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