[ CAS No. 29602-00-4 ]

Name: 29602-00-4|2-Hydroxy-4-(methoxycarbonyl)benzoic acid|97%
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Product Details of [ 29602-00-4 ]

CAS No. :	29602-00-4	MDL No. :	MFCD11100099
Formula :	C₉H₈O₅	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	GZKDVWHMQIMEQU-UHFFFAOYSA-N
M.W :	196.16	Pubchem ID :	15294629
Synonyms :

Safety of [ 29602-00-4 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501	UN#:
Hazard Statements:	H302-H312-H332	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 29602-00-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 29602-00-4 ]

[ 29602-00-4 ] Synthesis Path-Downstream 1~29

1
[ 67-56-1 ]
[ 636-94-2 ]
[ 29602-00-4 ]
[ 6342-72-9 ]

Reference： [1]Monatshefte fur Chemie,1900,vol. 21,p. 639
[2]Monatshefte fur Chemie,1900,vol. 21,p. 639

2
[ 85743-02-8 ]
[ 29602-00-4 ]

Reference： [1]Monatshefte fur Chemie,1907,vol. 28,p. 816

3
[ 6342-72-9 ]
[ 29602-00-4 ]

Yield	Reaction Conditions	Operation in experiment
66.7%	With sodium hydroxide; In methanol; at 0 - 5℃; for 1.0h;	Added to the reaction container 6.30g (0.030mol) and DMHT 5.00g NaOH (0.120mol) aqueous solution 200 ml, ice water bath stirring, 0-5 C reaction 60 min is poured into the beaker, dilute hydrochloric acid to pH= 8, undissolved substances, adding dilute hydrochloric acid to pH= 4.4, filtering, drying the filter cake obtained after recrystallization with methanol 4.76g alpha-MHT white solid, melting point 207.6-208.4 C, purity 98.8%, yield 81.0%.

Reference： [1]Patent: CN103664622,2016,B .Location in patent: Paragraph 0097; 0098
[2]Monatshefte fur Chemie,1900,vol. 21,p. 639

4
[ 1679-64-7 ]
[ 29602-00-4 ]
[ 364364-87-4 ]
2,6-dihydroxy-terephthalic acid monomethyl ester [ No CAS ]
2,5-dihydroxy-terephthalic acid monomethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With bubbling air In water at 20℃; for 12h; Irradiation;
	With bubling air In water at 20℃; for 12h; Irradiation;

Reference： [1]Yamada, Sachiko; Hokari, Hajime; Akasaka, Shinji; Iwamura, Michiko [Chemistry Letters, 1999, # 3, p. 197 - 198]
[2]Yamada, Sachiko; Hokari, Hajime; Akasaka, Shinji; Iwamura, Michiko [Chemistry Letters, 1999, # 3, p. 197 - 198]

5
[ 74-88-4 ]
acidic oxyterephthalacidic potassium [ No CAS ]
[ 29602-00-4 ]
[ 6342-72-9 ]

Reference： [1]Monatshefte fur Chemie,1902,vol. 23,p. 336,387

6
[ 67-56-1 ]
[ 328-90-5 ]
[ 29602-00-4 ]

Reference： [1]Photochemistry and Photobiology,2001,vol. 73,p. 463 - 468

7
[ 636-94-2 ]
[ 29602-00-4 ]

Reference： [1]Monatshefte fur Chemie,1900,vol. 21,p. 639
[2]Monatshefte fur Chemie,1900,vol. 21,p. 639
[3]Patent: CN103664622,2016,B

Yield	Reaction Conditions	Operation in experiment
		3 3-Hydroxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylcarbamoyl)benzoic acid Example 3 3-Hydroxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylcarbamoyl)benzoic acid The starting material, 2-hydroxy-terephthalic acid 4monomethyl ester, was obtained by preparing 2-hydroxy-terephthalica acid from the diazonium salt of 2-amino-terephthalic acid dimethyl ester, and successively monomethylating the result using methanolsulfric acid. The resulting 4-carboxylic acid methyl ester (417 mg) Was dissolved in 30 ml of ethyl acetate and 4-dimethylaminopyridine (51 mg) was added. To the solution, a solution of dicyclohexylcarbodiimido (442 mg, 1 eq.) in ethyl acetate (10 ml) was added, and then a solution of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylamine (454 mg) in ethyl acetate was added. After being allowed to stand overnight, the reaction mixture was extracted with ethyl acetate after water was added to the mixture. The extract was washed with 2N HCl, water, and 1N NaHCO3 and dried, and then concentrated to remove the solvent.
		3 Example 3 Example 3 3-Hydroxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylcarbamoyl)benzoic acid The starting material, 2-hydroxy-terephthalic acid 4-monomethyl ester, was obtained by preparing 2-hydroxy-terephthalica acid from the diazonium salt of 2-amino-terephthalic acid dimethyl ester, and successively monomethylating the result using methanol-sulfric acid. The resulting 4-carboxylic acid methyl ester (417 mg) was dissolved in 30 ml of ethyl acetate and 4-dimethylaminopyridine (51 mg) was added. To the solution, a solution of dicyclohexylcarbodiimido (442 mg, 1 eg.) in ethyl acetate (10 ml) was added, and then a solution of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylamine (454 mg) in ethyl acetate was added. After being allowed to stand overnight, the reaction mixture was extracted with ethyl acetate after water was added to the mixture. The extract was washed with 2N HCl, water, and 1N NaHCO3 and dried, and then concentrated to remove the solvent.

9
[ 7758-19-2 ]
[ 24589-98-8 ]
[ 29602-00-4 ]

Yield	Reaction Conditions	Operation in experiment
	In water; dimethyl sulfoxide;	Step-2 A solution of <strong>[24589-98-8]methyl 4-formyl-3-hydroxybenzoate</strong> (0.05 g, 0.27 mmol) and NaH2PO4.2H2O (0.11 g, 0.69 mmol) in DMSO: water, 2:1 (7.5 ml) was charged with sodium chlorite (0.075 g, 0.66 mmol) at 0 C. The reaction mixture was allowed to stir at room temperature for 12 hours. The reaction mixture was acidified with 1N HCl until pH=2. The precipitated white solid was filtered, washed with water several times and dried to give 2-hydroxy-4-(methoxycarbonyl)benzoic acid. Yield: (0.035 g, 65%). Molecular Weight: 196. MS (ES+): m/z=197.2 [MH+].
	In water; dimethyl sulfoxide;	Step-2 A solution of <strong>[24589-98-8]methyl 4-formyl-3-hydroxybenzoate</strong> (0.05 g, 0.27 mmol) and NaH2PO4.2H2O (0.11 g, 0.69 mmol) in DMSO:water, 2:1 (7.5 ml) was cooled to 0 C. and charged with sodium chlorite (0.075 g, 0.66 mmol). The reaction mixture was allowed to stir at room temperature for 12 hr. then acidified to pH 2 with 1N HCl. The precipitated white solid was filtered, washed with water several times and dried to give 2-hydroxy-4-(methoxycarbonyl)benzoic acid. Yield: (0.035 g, 65%). Molecular Weight: 196. MS (ES+): m/z=197.2 [MH+].

Reference： [1]Patent: US2014/161729,2014,A1 .Location in patent: Page/Page column
[2]Patent: US2014/161729,2014,A1 .Location in patent: Page/Page column

10
[ 29602-00-4 ]
[ 1411993-55-9 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; thionyl chloride; triethanolamine In tetrahydrofuran	3 Step-3 Step-3 A solution of 2-hydroxy-4-(methoxycarbonyl)benzoic acid (0.20 g, 1 mmol) in THF (10 mL) was charged with thionyl chloride (0.121 g, 10 mmol) at 0° C. The reaction mixture was heated to 45° C. for 4 hours. The reaction mixture was concentrated in vacuo. The residue was diluted in dry DCM (5 ml), and charged with a solution of o-t-butyl amine.HCl (0.512 g, 4 mmol) and TEA (0.412 g, 4 mmol) in DCM (15 ml) at 0° C. The reaction mixture was charged with 1N HCl solution (15 ml) and separated. The organic layer dried over sodium sulfate, filtered, and concentrated in vacuo to obtain 0.205 g crude product. The crude product was purified by column chromatography on silica gel using hexane-ethyl acetate as eluent to give methyl 4-(benzoyloxy)-3-formylbenzoate. Yield: (0.16 g, 58.8%). Molecular Weight: 267. MS (ES+): m/z=268.05 [MH+].

Reference： [1]Current Patent Assignee: COFERON, INC. - US2014/161729, 2014, A1 Location in patent: Page/Page column

11
[ 29602-00-4 ]
[ 1411993-54-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: hydrogenchloride; sodium hydrogencarbonate; thionyl chloride / tetrahydrofuran 2: trilithium citrate / tetrahydrofuran; water

Reference： [1]Current Patent Assignee: COFERON, INC. - US2014/161729, 2014, A1

12
[ 29602-00-4 ]
[ 1411993-53-7 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate In tetrahydrofuran	3 Step-3 Step-3 A solution of 2-hydroxy-4-(methoxycarbonyl)benzoic acid (0.05 g, 0.25 mmol) in THF (10 mL) was cooled to 0° C. and charged with thionyl chloride (0.303 g, 2.5 mmol) then the reaction mixture was heated to 45° C. for 4 hr. The reaction mixture was concentrated in vacuo and the residue was diluted with dry DCM (5 ml) and charged with a solution of o-phenyl amine.HCl (0.055 g, 0.38 mmol), NaHCO3 (0.038 mg, 0.45 mmol) and in DCM (15 ml) at 0° C. then the reaction was charged with 1N HCl solution (15 ml) and the organic was separated, dried over sodium sulfate, filtered, and concentrated in vacuo resulting in 0.07 g of crude product which was purified by column chromatography on silica gel eluting with hexane-ethyl acetate resulting in methyl 3-hydroxy-4-(phenoxycarbamoyl)benzoate. Yield: (0.5 g, 68%). Molecular Weight: 287. MS (ES+): m/z=288.1 [MH+].

Reference： [1]Current Patent Assignee: COFERON, INC. - US2014/161729, 2014, A1 Location in patent: Page/Page column

13
[ 29602-00-4 ]
[ 1411993-58-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: hydrogenchloride; triethanolamine; thionyl chloride / tetrahydrofuran 2: dimethyl sulfoxide; water 3: dmap / hexane 4: hydrogenchloride / [⁽²⁾H₆]acetone

Reference： [1]Current Patent Assignee: COFERON, INC. - US2014/161729, 2014, A1

14
[ 29602-00-4 ]
[ 1411993-56-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: hydrogenchloride; triethanolamine; thionyl chloride / tetrahydrofuran 2: dimethyl sulfoxide; water

Reference： [1]Current Patent Assignee: COFERON, INC. - US2014/161729, 2014, A1

15
[ 29602-00-4 ]
[ 1411993-57-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: hydrogenchloride; triethanolamine; thionyl chloride / tetrahydrofuran 2: dimethyl sulfoxide; water 3: dmap / hexane

Reference： [1]Current Patent Assignee: COFERON, INC. - US2014/161729, 2014, A1

16
[ 29602-00-4 ]
[ 593-56-6 ]
[ 1411992-84-1 ]

Yield	Reaction Conditions	Operation in experiment
64%	With thionyl chloride; triethylamine In dichloromethane for 2h;	10.F.2 Step-2 Step-2 [0444] Products from step-1 were converted to desired amides either by conversion to acid chloride and subsequent reaction with ammonia/desired amine or by coupling reaction using EDCI-HOBT in DMF followed by usual work-up as described in method-A (step-4.) Crude products were purified by column chromatography over silica gel using methanol (0-30%) in chloroform. [0445] Intermediates C-76 & D-76 were synthesized by Heck reaction of the desired o-Hydroxy-4-bromo benzamides (Synthesized form 4-bromo-2-hydroxybenzoic acid as per general procedure described earlier) using ethyl acrylate and following the procedure described in the literature for analogous compounds (Bull. Korean Chem. Soc. 1999, Vol. 20, 232-236) [0446] Intermediate C-86 was synthesized by the procedure described in the literature (J. Med. Chem. 43, 1670-1683, 2000) [0447] The details of compounds synthesized are as below in Table 32. B-75 (1 eq), DCM (75 Vol), TEA (1.5 eq) Thionyl chloride (1.5 eq) 0° C. 1 h. NH2OMe•HCl (1.5 eq) DCM (32 vol), TEA (2 eq) was added and stirred for 2 h. purified by column chromatography (0-30% Methanol-chloroform), Yield - 64%,

Reference： [1]Current Patent Assignee: CORNELL UNIVERSITY; PURDUE UNIVERSITY SYSTEM - US2014/194383, 2014, A1 Location in patent: Paragraph 0444-0447

17
[ 24589-98-8 ]
[ 29602-00-4 ]

Yield	Reaction Conditions	Operation in experiment
35.46%	With sodium chlorite; sodium dihydrogenphosphate dihydrate; dihydrogen peroxide; In water; acetonitrile; at 0 - 20℃;	Ortho hydroxy aromatic aldehydes, with carbethoxy or methoxy functionality at suitable position were oxidized to get o-carboxy phenols which were then converted to amide by reaction either with ammonia/o-Methyl hydroxylamine. Ester functionality was then hydrolyzed to get required o-Hydroxy amido carboxylic acid, which upon coupling with tert-butyl 3-(piperidin-4-yl)benzylcarbamate and subsequent deprotection in acidic media afforded the title compounds. Step-1 [0443] Desired Carbmethoxy hydroxy benzaldehyde was dissolved in Acetonitrile and aq solution of di-sodium hydrogen phosphate & 30% hydrogen peroxide was then added and reaction mass cooled to 0 C. Aq. solution of Sodium chlorite was added to the reaction mass drop wise and reaction mass was allowed to warm to room temperature. Stirring continued at room temperature and reaction was monitored by LCMS till maximum starting was consumed. Reaction mass was then concentrated, residue was acidified with aq. HCl and product extracted in ethyl acetate. Ethyl acetate extract dried over sodium sulfate and concentrated to get the crude product which was sufficient pure for the use in next step. The details of the compounds synthesized are as below in Table 31. 4-Formyl, 3-Hydroxy methyl benzoate, (1 eq) ACN (65 V), NaH2PO4?2H2O (0.32 eq in 11 V water), H2O2 30% solution (5 eq) NaClO2 (1.4 eq in 10 V of water) RT 2 h. Yield - 35.46%

Reference： [1]Patent: US2014/194383,2014,A1 .Location in patent: Paragraph 0442-0443

18
[ 29602-00-4 ]
[ 876165-62-7 ]

Yield	Reaction Conditions	Operation in experiment
10%	With ammonium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water; N,N-dimethyl-formamide at 20℃; for 14h;	10.F.2 Step-2 Step-2 [0444] Products from step-1 were converted to desired amides either by conversion to acid chloride and subsequent reaction with ammonia/desired amine or by coupling reaction using EDCI-HOBT in DMF followed by usual work-up as described in method-A (step-4.) Crude products were purified by column chromatography over silica gel using methanol (0-30%) in chloroform. [0445] Intermediates C-76 & D-76 were synthesized by Heck reaction of the desired o-Hydroxy-4-bromo benzamides (Synthesized form 4-bromo-2-hydroxybenzoic acid as per general procedure described earlier) using ethyl acrylate and following the procedure described in the literature for analogous compounds (Bull. Korean Chem. Soc. 1999, Vol. 20, 232-236) [0446] Intermediate C-86 was synthesized by the procedure described in the literature (J. Med. Chem. 43, 1670-1683, 2000) [0447] The details of compounds synthesized are as below in Table 32. EDCI (1.1 eq.), HOBT (1.1 eq.), aq ammonia (4 eq.), DMF (60 vol), RT, 14 h, purified by column chromatography (0- 30% Methanol-chloroform), Yield - 10%,

Reference： [1]Current Patent Assignee: CORNELL UNIVERSITY; PURDUE UNIVERSITY SYSTEM - US2014/194383, 2014, A1 Location in patent: Paragraph 0444-0447

19
[ 29602-00-4 ]
[ 773056-90-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium hydroxide / water; N,N-dimethyl-formamide / 14 h / 20 °C 2: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

Reference： [1]Current Patent Assignee: CORNELL UNIVERSITY; PURDUE UNIVERSITY SYSTEM - US2014/194383, 2014, A1

20
[ 29602-00-4 ]
[ 1431546-51-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium hydroxide / water; N,N-dimethyl-formamide / 14 h / 20 °C 2: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C

Reference： [1]Current Patent Assignee: CORNELL UNIVERSITY; PURDUE UNIVERSITY SYSTEM - US2014/194383, 2014, A1

21
[ 29602-00-4 ]
4-(4-(3-(aminomethyl)phenyl)piperidine-1-carbonyl)-2-hydroxybenzamide trifluoroacetate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium hydroxide / water; N,N-dimethyl-formamide / 14 h / 20 °C 2: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C 4: hydrogenchloride / methanol / 4 h / 20 °C

Reference： [1]Current Patent Assignee: CORNELL UNIVERSITY; PURDUE UNIVERSITY SYSTEM - US2014/194383, 2014, A1

22
[ 29602-00-4 ]
C₉H₇ClO₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride; triethylamine In dichloromethane at 0℃; for 1h;

Reference： [1]Giardina, Sarah F.; Werner, Douglas S.; Pingle, Maneesh; Feinberg, Philip B.; Foreman, Kenneth W.; Bergstrom, Donald E.; Arnold, Lee D.; Barany, Francis [Journal of Medicinal Chemistry, 2020, vol. 63, # 6, p. 3004 - 3027]

23
[ 29602-00-4 ]
[ 1411992-84-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: thionyl chloride; triethylamine / dichloromethane / 1 h / 0 °C 2: triethylamine / dichloromethane / 2 h / 0 °C

24
[ 29602-00-4 ]
[ 1411992-88-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: thionyl chloride; triethylamine / dichloromethane / 1 h / 0 °C 2: triethylamine / dichloromethane / 2 h / 0 °C 3: lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C

25
[ 29602-00-4 ]
[ 1411992-92-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: thionyl chloride; triethylamine / dichloromethane / 1 h / 0 °C 2.1: triethylamine / dichloromethane / 2 h / 0 °C 3.1: lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C 4.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.25 h 4.2: 4 h / 20 °C

26
[ 29602-00-4 ]
[ 1411991-90-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: thionyl chloride; triethylamine / dichloromethane / 1 h / 0 °C 2.1: triethylamine / dichloromethane / 2 h / 0 °C 3.1: lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C 4.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.25 h 4.2: 4 h / 20 °C 5.1: hydrogenchloride / methanol / 4 h / 20 °C

27
[ 29602-00-4 ]
tert-butyl ((1′-(3-hydroxy-4-(methoxycarbamoyl)benzoyl)-2H-spiro[benzofuran-3,4′-piperidin]-5-yl)methyl)carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: thionyl chloride; triethylamine / dichloromethane / 1 h / 0 °C 2: triethylamine / dichloromethane / 2 h / 0 °C 3: lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C 4: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 3 h / 20 °C

28
[ 29602-00-4 ]
4-(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-carbonyl)-2-hydroxy-N-methoxybenzamide trifluoroacetate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: thionyl chloride; triethylamine / dichloromethane / 1 h / 0 °C 2: triethylamine / dichloromethane / 2 h / 0 °C 3: lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C 4: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 3 h / 20 °C 5: dichloromethane / 3 h / 20 °C

29
[ 636-94-2 ]
S-(5′-adenosyl)-L-methionine [ No CAS ]
[ 29602-00-4 ]

Yield	Reaction Conditions	Operation in experiment
	With histidine tagged carboxyl methyltransferase from Aspergillus fumigatus; histidine tagged S-adenosylhomocysteine nucleosidase In aq. buffer at 25℃; for 16h; Enzymatic reaction; regioselective reaction;

Reference： [1]Ashbrook, Chloe; Carnell, Andrew J.; Goulding, Ellie; Hatton, Harry; Johnson, James R.; Kershaw, Neil M.; McCue, Hannah V.; Rigden, Daniel J.; Ward, Lucy C. [Angewandte Chemie - International Edition, 2022, vol. 61, # 14][Angew. Chem., 2022, vol. 134, # 14]

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P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 29602-00-4 ]

Quality Control of [ 29602-00-4 ]

Related Doc. of [ 29602-00-4 ]

Product Details of [ 29602-00-4 ]

Safety of [ 29602-00-4 ]

Application In Synthesis of [ 29602-00-4 ]

[ 29602-00-4 ] Synthesis Path-Downstream 1~29

Related Functional Groups of [ 29602-00-4 ]

Aryls

Esters

Carboxylic Acids

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 29602-00-4 ]