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Chemical Structure| 30071-93-3 Chemical Structure| 30071-93-3
Chemical Structure| 30071-93-3

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Product Details of 3',5'-Bis(trifluoromethyl)acetophenone

CAS No. :30071-93-3
Formula : C10H6F6O
M.W : 256.14
SMILES Code : CC(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O
MDL No. :MFCD00009910
InChI Key :MCYCSIKSZLARBD-UHFFFAOYSA-N
Pubchem ID :121616

Safety of 3',5'-Bis(trifluoromethyl)acetophenone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 3',5'-Bis(trifluoromethyl)acetophenone

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 30071-93-3 ]

[ 30071-93-3 ] Synthesis Path-Downstream   1~4

  • 2
  • [ 30071-93-3 ]
  • [ 349-58-6 ]
YieldReaction ConditionsOperation in experiment
63% With dihydrogen peroxide; trifluoroacetic anhydride; In chloroform; water; at 0 - 70℃; for 6.5h; A mixture of 100 g (0.39 mol) of 3,5-bis(trifluoromethyl)acetophenone obtained above, 155.2 g of (0.74 mol) of trifluoroacetic anhydride and 400 ml of chloroform was stirred at 0°C in a nitrogen atmosphere. After adding 19.7 g (0.52 mol) of a 90percent hydrogen peroxide aqueous solution from a dropping funnel over 30 min and stirring the mixture for one our, the temperature was raised to 70°C to proceed the reaction for 5 h. After completion of the reaction, the temperature was returned to room temperature. The reaction product solution was poured into a separating funnel containing a saturated brine and washed with water. The organic phase separated was analyzed by gas chromatography. It was confirmed that 57.5 g (0.25 mol) of the aimed 3,5-bis(trifluoromethyl)phenol was produced (yield: 67percent). By vacuum distillation, 53.3 g (0.23 mol) of 3,5-bis(trifluoromethyl)phenol was isolated (yield: 63percent). The purity determined by gas chromatography was 99percent or higher. The results of ICP total elements analysis showed that none of Li, Na, K, Mg, Ca, Sr, Ba, Sc, Y, Ti, Zr, V, Nb, Cr, Mo, W, Mn, Fe, Ru, Co, Rh, Ni, Pd, Pt, Cu, Ag, Au, Zn, Cd, Al, In, Si, Sn, Pb, P, Sb and S were detected, and the content of each of group 1 and group 2 elements was 1 ppm or lower.
  • 3
  • [ 30071-93-3 ]
  • [ 110677-45-7 ]
  • [ 1367364-65-5 ]
YieldReaction ConditionsOperation in experiment
63% With potassium hydroxide; In ethanol; dichloromethane; water; at 20℃; The 768mg (3mmol) 3,5- two trifluoromethyl acetophenone, 160mg (4mmol) sodium hydroxide was placed in 100mLSingle neck flask was added 10 drops of water, 20 mL of ethanol and dissolved; the 813mg (3mmol) 4- (9- (9H- carbazoleYl)) benzaldehyde was dissolved in 10mL of dichloromethane, ethanol and added dropwise to the mixture, stirred overnight at room temperature, overFiltered, ethanol, washed with petroleum ether, and dried to give a yellow solid (LJZ-5-31) 956mg, Yield = 63%.
  • 4
  • [ 30071-93-3 ]
  • [ 475250-52-3 ]
  • 2-[3,5-bis(trifluoromethyl)phenyl]-1-(4-methoxyphenyl)propan-2-ol [ No CAS ]
 

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